{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:19:11Z","timestamp":1788877151278,"version":"build-2803163510"},"reference-count":26,"publisher":"BMJ","issue":"19","license":[{"start":{"date-parts":[[2023,8,15]],"date-time":"2023-08-15T00:00:00Z","timestamp":1692057600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005009","name":"Stiftelsen Assar Gabrielssons Fond","doi-asserted-by":"publisher","award":["FB-2021"],"award-info":[{"award-number":["FB-2021"]}],"id":[{"id":"10.13039\/501100005009","id-type":"DOI","asserted-by":"publisher"}]},{"name":"The Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement","award":["ALFGBG-30411"],"award-info":[{"award-number":["ALFGBG-30411"]}]},{"name":"The Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement","award":["ALFGBG-720691"],"award-info":[{"award-number":["ALFGBG-720691"]}]},{"name":"The Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement","award":["ALFGBG-813511"],"award-info":[{"award-number":["ALFGBG-813511"]}]},{"name":"The Swedish state under the agreement between the Swedish Government and the county councils, the ALF-agreement","award":["ALFGBG-965149"],"award-info":[{"award-number":["ALFGBG-965149"]}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["20180379"],"award-info":[{"award-number":["20180379"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2019-00193"],"award-info":[{"award-number":["2019-00193"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["VRREG 2022-00166"],"award-info":[{"award-number":["VRREG 2022-00166"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2023,6,22]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To assess the associations between cardiorespiratory fitness (CRF) in young men and the incidence of site-specific cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A Swedish population-based cohort study with register linkage of men who underwent military conscription in 1968\u20132005 was undertaken. CRF was assessed by maximal aerobic workload cycle test at conscription. Cox regression models assessed linear associations and included CRF, age, year and site of conscription, body mass index and parental level of education. CRF was also categorised into low, moderate and high for facilitated interpretation and results comparing high and low CRF are reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Primary analyses were performed in 1 078 000 men, of whom 84\u2009117 subsequently developed cancer in at least one site during a mean follow-up of 33 years. Higher CRF was linearly associated with a lower hazard ratio (HR) of developing cancer in the head and neck (n=2738, HR 0.81, 95% CI 0.74 to 0.90), oesophagus (n=689, HR 0.61, 95% CI 0.50 to 0.74), stomach (n=902, HR 0.79, 95% CI 0.67 to 0.94), pancreas (n=1280, HR 0.88, 95% CI 0.76 to 1.01), liver (n=1111, HR 0.60, 95% CI 0.51 to 0.71), colon (n=3222, HR 0.82, 95% CI 0.75 to 0.90), rectum (n=2337, HR 0.95, 95% CI 0.85 to 1.05), kidney (n=1753, HR 0.80, 95% CI 0.70 to 0.90) and lung (n=1635, HR 0.58, 95% CI 0.51 to 0.66). However, higher CRF predicted a higher hazard of being diagnosed with prostate cancer (n=14\u2009232, HR 1.07, 95% CI 1.03 to 1.12) and malignant skin cancer (n=23\u2009064, HR 1.31, 95% CI 1.27 to 1.36).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We report a number of protective associations between higher CRF in healthy young men and the subsequent hazard of site-specific cancers. These results have implications for public health policymaking, strengthening the incentive to promote health through improving CRF in youth.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsports-2022-106617","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:19Z","timestamp":1692144019000},"page":"1248-1256","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":22,"title":["Associations between cardiorespiratory fitness in youth and the incidence of site-specific cancer in men: a cohort study with register linkage"],"prefix":"10.1136","volume":"57","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1946-3529","authenticated-orcid":false,"given":"Aron","family":"Onerup","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Mehlig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnes af","family":"Geijerstam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elin","family":"Ekblom-Bak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans Georg","family":"Kuhn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"Lissner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"\u00c5berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"B\u00f6rjesson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,8,15]]},"reference":[{"key":"2024051423014750000_57.19.1248.1","unstructured":"World Health Organization . 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