{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T20:51:17Z","timestamp":1792702277877,"version":"4.5.0"},"reference-count":30,"publisher":"BMJ","issue":"24","funder":[{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["DFF-6110-00045"],"award-info":[{"award-number":["DFF-6110-00045"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004836","name":"Danish Council for Independent Research","doi-asserted-by":"crossref","award":["DFF-6110-00045B"],"award-info":[{"award-number":["DFF-6110-00045B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Br J Sports Med"],"accepted":{"date-parts":[[2023,10,5]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate potential differences in structural knee joint damage assessed by MRI and patient-reported outcomes (PROMs) at 2-year follow-up between young adults randomised to early surgery or exercise and education with optional delayed surgery for a meniscal tear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      A secondary analysis of a multicentre randomised controlled trial including 121 patients (18\u201340 years) with an MRI-verified meniscal tear. For this study, only patients with 2-year follow-up were included. The main outcomes were the difference in worsening of structural knee damage, assessed by MRI using the Anterior Cruciate Ligament OsteoArthrits Score, and the difference in change in the mean score of four Knee Injury and Osteoarthritis Outcome Score (KOOS\n                      <jats:sub>4<\/jats:sub>\n                      ) subscales covering pain, symptoms, function in sport and recreation, and quality of life, from baseline to 2 years.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 82\/121 (68%) patients completed the 2-year follow-up (39 from the surgical group and 43 from the exercise group). MRI-defined cartilage damage had developed or progressed in seven (9.1%) patients and osteophytes developed in two (2.6%) patients. The worsening of structural damage from baseline to 2-year follow-up was similar between groups. The mean (95%\u2009CI) adjusted differences in change in KOOS\n                      <jats:sub>4<\/jats:sub>\n                      between intervention groups from baseline to 2\u2009years was \u22121.4 (\u22129.1, 6.2) points. The mean improvement in KOOS\n                      <jats:sub>4<\/jats:sub>\n                      was 16.4 (10.4, 22.4) in the surgical group and 21.5 (15.0, 28.0) in the exercise group. No between group differences in improvement were found in the KOOS subscales.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>\n                      The 2-year worsening of MRI-defined structural damage was limited and similar in young adult patients with a meniscal tear treated with surgery or exercise with optional delayed surgery. Both groups had similar clinically relevant improvements in KOOS\n                      <jats:sub>4<\/jats:sub>\n                      , suggesting the choice of treatment strategy does not impact 2-year structural knee damage or PROMs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" specific-use=\"clinicaltrial results\" xlink:href=\"NCT02995551\">NCT02995551<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bjsports-2023-107352","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T13:20:19Z","timestamp":1698240019000},"page":"1566-1572","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Two-year MRI-defined structural damage and patient-reported outcomes following surgery or exercise for meniscal tears in young adults"],"prefix":"10.1136","volume":"57","clinical-trial-number":[{"clinical-trial-number":"nct02995551","registry":"10.18810\/clinical-trials-gov","type":"results"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8632-4596","authenticated-orcid":false,"given":"Stine Haugaard","family":"Clausen","sequence":"first","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Center for Muscle and Joint Health, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4336-7059","authenticated-orcid":false,"given":"S\u00f8ren T","family":"Skou","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Center for Muscle and Joint Health, Odense, Denmark"},{"name":"The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, N\u00e6stved-Slagelse-Ringsted Hospitals, Region Zealand, Slagelse, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikael Ploug","family":"Boesen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitar Ivanon","family":"Radev","sequence":"additional","affiliation":[{"name":"Department of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Engin Yeter","family":"Kurt","sequence":"additional","affiliation":[{"name":"Department of Radiology, Copenhagen University Hospital Bispebjerg and Frederiksberg, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4627-1338","authenticated-orcid":false,"given":"Camma","family":"Damsted","sequence":"additional","affiliation":[{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Center for Muscle and Joint Health, Odense, Denmark"},{"name":"The Research Unit PROgrez, Department of Physiotherapy and Occupational Therapy, N\u00e6stved-Slagelse-Ringsted Hospitals, Region Zealand, Slagelse, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"H\u00f6lmich","sequence":"additional","affiliation":[{"name":"Department of Orthopedic Surgery, Sports Orthopaedic Research Center\u2013Copenhagen (SORC-C), Arthroscopic Center, Copenhagen University Hospital, Amager-Hvidovre Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Lind","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Aarhus University Hospital Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofus","family":"T\u00f8rring","sequence":"additional","affiliation":[{"name":"Department of Radiology, Aalborg University Hospital, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christin","family":"Isaksen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Diagnostic Centre, University Research Clinic for Innovative Patient Pathways, Silkeborg Regional Hospital, Silkeborg, 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