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MVPA was measured at baseline, year 1, year 4 and year 8 using an RT3 accelerometer. The outcome was progression to CKD, defined as eGFR&lt;60\u2009mL\/min per 1.73\u2009m<jats:sup>2<\/jats:sup>with a drop of \u226530%\u2009or end-stage kidney disease. Cox hazards models were fitted to examine the association between MVPA and outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Over a median follow-up of 12.0 years, 567 participants experienced progression to CKD. Overall, there was a linear inverse association of cumulative average total MVPA (per 100\u2009min\/week higher amount, HR: 0.91; 95% CI: 0.86 to 0.96) and MVPA accumulated in bouts of \u226510\u2009min (per 100\u2009minutes\/week higher amount, HR: 0.81; 95% CI: 0.72 to 0.91) with progression to CKD. Moreover, an increase in total MVPA from baseline to year 4 (the fourth quartile, \u226563.2\u2009min\/week) was associated with a 33% lower risk of progression to CKD compared with the largest MVPA reduction (the first quartile, &lt;\u2212198.3\u2009min\/week). A lower risk of progression to CKD was also observed for increases in MVPA accumulated in bouts of both &lt;10\u2009min and \u226510\u2009min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Longer MVPA time and increases in MVPA was associated with a reduced risk of progression to CKD in adults with overweight\/obesity and T2D.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bjsports-2023-107564","type":"journal-article","created":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T01:00:13Z","timestamp":1707267613000},"page":"313-319","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Association of accelerometer-measured physical activity and its change with progression to chronic kidney disease in adults with type 2 diabetes and 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