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Included experimental interventions were any fever therapy, and the control intervention had to be no fever therapy (with or without placebo\/sham).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction and synthesis<\/jats:title>\n                    <jats:p>Two authors independently selected studies, extracted data, and assessed the risk of bias. Primary outcomes were all cause mortality and serious adverse events. Secondary outcomes were quality of life and non-serious adverse events. Aggregate data were synthesised with meta-analyses, subgroup analyses, and trial sequential analyses, and the evidence was assessed using the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) approach.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Forty two trials assessing 5140 participants were included. Twenty three trials assessed 11 different antipyretic drugs, 11 trials assessed physical cooling, and eight trials assessed a combination of antipyretic drugs and physical cooling. Of the participants, 3007 were critically ill, 1892 were non-critically ill, 3277 had infectious fever, and 1139 had non-infectious fever. All trials were assessed as being at high risk of bias. Meta-analysis and trial sequential analysis showed that the hypothesis that fever therapy reduces the risk of death (risk ratio 1.04, 95% confidence interval 0.90 to 1.19; I\n                      <jats:sup>2<\/jats:sup>\n                      =0%; P=0.62; 16 trials; high certainty evidence) and the risk of serious adverse events (risk ratio 1.02, 0.89 to 1.17; I\n                      <jats:sup>2<\/jats:sup>\n                      =0%; P=0.78; 16 trials; high certainty evidence) could be rejected. One trial assessing quality of life was included, showing no difference between fever therapy and control. Meta-analysis and trial sequential analysis showed that the hypothesis that fever therapy reduces the risk of non-serious adverse events could be neither confirmed nor rejected (risk ratio 0.92, 0.67 to 1.25; I\n                      <jats:sup>2<\/jats:sup>\n                      =66.5%; P=0.58; four trials; very low certainty evidence).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Fever therapy does not seem to affect the risk of death and serious adverse events.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Systematic review registration<\/jats:title>\n                    <jats:p>PROSPERO CRD42019134006<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmj-2021-069620","type":"journal-article","created":{"date-parts":[[2022,7,12]],"date-time":"2022-07-12T06:55:13Z","timestamp":1657608913000},"page":"e069620","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":38,"title":["Fever therapy in febrile adults: systematic review with meta-analyses and trial sequential analyses"],"prefix":"10.1136","volume":"378","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1858-2371","authenticated-orcid":false,"given":"Johan","family":"Holgersson","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Helsingborg Hospital, Helsingborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameldina","family":"Ceric","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Helsingborg Hospital, Helsingborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naqash","family":"Sethi","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit \u2013 Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences, Lund University, Lund, Sweden"},{"name":"Department of Clinical Sciences, Helsingborg Hospital, Helsingborg, Sweden"},{"name":"Joint last authors"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janus Christian","family":"Jakobsen","sequence":"additional","affiliation":[{"name":"Copenhagen Trial Unit \u2013 Centre for Clinical Intervention Research, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"},{"name":"Department of Regional Health Research, Faculty of Health Sciences, University of Southern Denmark, Denmark"},{"name":"Joint last authors"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,7,12]]},"reference":[{"key":"2025110101521513000_378.jul12_6.e069620.1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.j5468"},{"key":"2025110101521513000_378.jul12_6.e069620.2","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-13-7677-1_1"},{"key":"2025110101521513000_378.jul12_6.e069620.3","doi-asserted-by":"publisher","DOI":"10.1086\/317513"},{"key":"2025110101521513000_378.jul12_6.e069620.4","unstructured":"Dinarello CA, Porat R. 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