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The current recommendations from the World Health Organization, Centers for Disease Control and Prevention, and professional organizations are for pregnant, postpartum, and lactating women to receive covid-19 vaccination. Pregnancy specific considerations involve potential effects of vaccination on fetal development, placental transfer of antibodies, and safety of maternal vaccination. Although pregnancy was an exclusion criterion in initial clinical trials of covid-19 vaccines, observational data have been rapidly accumulating and thus far confirm that the benefits of vaccination outweigh the potential risks. This review examines the evidence supporting the effectiveness, immunogenicity, placental transfer, side effects, and perinatal outcomes of maternal covid-19 vaccination. Additionally, it describes factors associated with vaccine hesitancy in pregnancy. Overall, studies monitoring people who have received covid-19 vaccines during pregnancy have not identified any pregnancy specific safety concerns. Additional information on non-mRNA vaccines, vaccination early in pregnancy, and longer term outcomes in infants are needed. To collect this information, vaccination during pregnancy must be prioritized in vaccine research.<\/jats:p>","DOI":"10.1136\/bmj-2021-069741","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T06:20:27Z","timestamp":1660112427000},"page":"e069741","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":100,"title":["Covid-19 vaccination in pregnancy"],"prefix":"10.1136","volume":"378","author":[{"given":"Martina L","family":"Badell","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA. 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FOGSI Position Statement: COVID Vaccination for Pregnant and Breastfeeding Women. https:\/\/www.fogsi.org\/wp-content\/uploads\/covid19\/fogsi-statement-on-covid-vaccination-in-pregnancy-and-bf.pdf."},{"key":"2025110101525271000_378.aug10_2.e069741.124","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10132902"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj-2021-069741","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj-2021-069741","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:53:00Z","timestamp":1761987180000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj-2021-069741"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,10]]},"references-count":124,"alternative-id":["10.1136\/bmj-2021-069741"],"URL":"https:\/\/doi.org\/10.1136\/bmj-2021-069741","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,10]]}}}