{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:38:54Z","timestamp":1793878734554,"version":"4.7.0"},"reference-count":201,"publisher":"BMJ","license":[{"start":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T00:00:00Z","timestamp":1705449600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Rheumatoid arthritis (RA) is one of the most common immune mediated inflammatory diseases. People with rheumatoid arthritis present with pain, swelling, and stiffness that typically affects symmetrically distributed small and large joints. Without effective treatment, significant joint damage, disability, and work loss develop, owing to chronic inflammation of the joint lining (synovium). Over the past 25 years, the management of this condition has been revolutionized, resulting in substantially higher levels of disease remission and better long term outcomes. This improvement reflects a paradigm shift towards early and aggressive pharmacological intervention coupled with a proliferation in treatment choice, in turn related to enhanced pathobiological understanding and the advent of new drugs for rheumatoid arthritis. Following an overview of these developments from a historical perspective, and with a general audience in mind, this review focuses on newer, targeted treatments in an ever evolving landscape. The review highlights ongoing areas of debate and unmet need, including the proportion of patients with persistent, difficult-to-treat disease, despite recent advances. Also discussed are personalized, strategic approaches to individual patients, the role for imaging in clinical decision making, and the goal of sustained, drug free remission and disease prevention in the future.<\/jats:p>","DOI":"10.1136\/bmj-2022-070856","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T08:10:11Z","timestamp":1705479011000},"page":"e070856","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":312,"title":["Therapeutic advances in rheumatoid arthritis"],"prefix":"10.1136","volume":"384","author":[{"given":"Philip","family":"Brown","sequence":"first","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"},{"name":"National Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne Hospitals and Cumbria, Northumberland; and Tyne and Wear NHS Foundation Trusts, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur G","family":"Pratt","sequence":"additional","affiliation":[{"name":"Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK"},{"name":"National Institute for Health and Care Research Newcastle Biomedical Research Centre, Newcastle University, Newcastle upon Tyne Hospitals and Cumbria, Northumberland; and Tyne and Wear NHS Foundation Trusts, Newcastle upon Tyne, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimme L","family":"Hyrich","sequence":"additional","affiliation":[{"name":"Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Sciences Centre, Manchester, UK"},{"name":"National Institute for Health and Care Research Manchester Biomedical Research Centre, Manchester University Hospitals NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,1,17]]},"reference":[{"key":"2025110101585622000_384.jan17_6.e070856.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00457-9"},{"key":"2025110101585622000_384.jan17_6.e070856.2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2010.138461"},{"key":"2025110101585622000_384.jan17_6.e070856.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-857X(05)70201-5"},{"key":"2025110101585622000_384.jan17_6.e070856.4","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2012-201960"},{"key":"2025110101585622000_384.jan17_6.e070856.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-023-06628-2"},{"key":"2025110101585622000_384.jan17_6.e070856.6","unstructured":"Morse A. Services for people with rheumatoid arthritis. National Audit Office 2009. https:\/\/www.nao.org.uk\/reports\/services-for-people-with-rheumatoid-arthritis\/"},{"key":"2025110101585622000_384.jan17_6.e070856.7","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2019-001084"},{"key":"2025110101585622000_384.jan17_6.e070856.8","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq135"},{"key":"2025110101585622000_384.jan17_6.e070856.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2021.102776"},{"key":"2025110101585622000_384.jan17_6.e070856.10","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kep252"},{"key":"2025110101585622000_384.jan17_6.e070856.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2012.02.005"},{"key":"2025110101585622000_384.jan17_6.e070856.12","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key013"},{"key":"2025110101585622000_384.jan17_6.e070856.13","doi-asserted-by":"crossref","unstructured":"Soussi BG Duch K Cordtz RL . Temporal trends in mortality in patients with rheumatoid arthritis: a Danish population-based matched cohort study. Rheumatology, 2023.","DOI":"10.1093\/rheumatology\/kead325"},{"key":"2025110101585622000_384.jan17_6.e070856.14","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212131"},{"key":"2025110101585622000_384.jan17_6.e070856.15","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.1"},{"key":"2025110101585622000_384.jan17_6.e070856.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.11.009"},{"key":"2025110101585622000_384.jan17_6.e070856.17","doi-asserted-by":"publisher","DOI":"10.1038\/nri2094"},{"key":"2025110101585622000_384.jan17_6.e070856.18","first-page":"449","article-title":"Interleukin-1 and tumour necrosis factor mRNA expression in rheumatoid arthritis: prolonged production of IL-1 alpha","volume":"73","author":"Buchan","year":"1988","journal-title":"Clin Exp Immunol"},{"key":"2025110101585622000_384.jan17_6.e070856.19","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780310816"},{"key":"2025110101585622000_384.jan17_6.e070856.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05246-0"},{"key":"2025110101585622000_384.jan17_6.e070856.21","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.20.9784"},{"key":"2025110101585622000_384.jan17_6.e070856.22","unstructured":"(NICE) NIfHaCE. Rheumatoid arthritis in adults: management [NG100]. 2018."},{"key":"2025110101585622000_384.jan17_6.e070856.23","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209166"},{"key":"2025110101585622000_384.jan17_6.e070856.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102509"},{"key":"2025110101585622000_384.jan17_6.e070856.25","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208849"},{"key":"2025110101585622000_384.jan17_6.e070856.26","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175207"},{"key":"2025110101585622000_384.jan17_6.e070856.27","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00963"},{"key":"2025110101585622000_384.jan17_6.e070856.28","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-021-00726-8"},{"key":"2025110101585622000_384.jan17_6.e070856.29","doi-asserted-by":"publisher","DOI":"10.1136\/ard.51.2.177"},{"key":"2025110101585622000_384.jan17_6.e070856.30","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-124-8-199604150-00001"},{"key":"2025110101585622000_384.jan17_6.e070856.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)01300-7"},{"key":"2025110101585622000_384.jan17_6.e070856.32","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(01)00872-5"},{"key":"2025110101585622000_384.jan17_6.e070856.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16676-2"},{"key":"2025110101585622000_384.jan17_6.e070856.34","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.123976"},{"key":"2025110101585622000_384.jan17_6.e070856.35","doi-asserted-by":"publisher","DOI":"10.1002\/art.1780380107"},{"key":"2025110101585622000_384.jan17_6.e070856.36","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-207524"},{"key":"2025110101585622000_384.jan17_6.e070856.37","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221957"},{"key":"2025110101585622000_384.jan17_6.e070856.38","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30636-X"},{"key":"2025110101585622000_384.jan17_6.e070856.39","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208916"},{"key":"2025110101585622000_384.jan17_6.e070856.40","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.9.975"},{"key":"2025110101585622000_384.jan17_6.e070856.41","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.159.21.2542"},{"key":"2025110101585622000_384.jan17_6.e070856.42","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/39.6.655"},{"key":"2025110101585622000_384.jan17_6.e070856.43","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.m4328"},{"key":"2025110101585622000_384.jan17_6.e070856.44","article-title":"Leflunomide for treating rheumatoid arthritis","volume":"2002","author":"Osiri","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.45","article-title":"Sulfasalazine for rheumatoid arthritis","volume":"1998","author":"Suarez-Almazor","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(99)80399-4"},{"key":"2025110101585622000_384.jan17_6.e070856.47","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24596"},{"key":"2025110101585622000_384.jan17_6.e070856.48","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223356"},{"key":"2025110101585622000_384.jan17_6.e070856.49","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab917"},{"key":"2025110101585622000_384.jan17_6.e070856.50","first-page":"36","article-title":"The efficacy of folic acid and folinic acid in reducing methotrexate gastrointestinal toxicity in rheumatoid arthritis. A metaanalysis of randomized controlled trials","volume":"25","author":"Ortiz","year":"1998","journal-title":"J Rheumatol"},{"key":"2025110101585622000_384.jan17_6.e070856.51","doi-asserted-by":"publisher","DOI":"10.7326\/M19-3369"},{"key":"2025110101585622000_384.jan17_6.e070856.52","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab917"},{"key":"2025110101585622000_384.jan17_6.e070856.53","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11266"},{"key":"2025110101585622000_384.jan17_6.e070856.54","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012437"},{"key":"2025110101585622000_384.jan17_6.e070856.55","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1777"},{"key":"2025110101585622000_384.jan17_6.e070856.56","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012591"},{"key":"2025110101585622000_384.jan17_6.e070856.57","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-222586"},{"key":"2025110101585622000_384.jan17_6.e070856.58","doi-asserted-by":"publisher","DOI":"10.1007\/s40744-018-0138-y"},{"key":"2025110101585622000_384.jan17_6.e070856.59","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ket018"},{"key":"2025110101585622000_384.jan17_6.e070856.60","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2018.10.002"},{"key":"2025110101585622000_384.jan17_6.e070856.61","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204769"},{"key":"2025110101585622000_384.jan17_6.e070856.62","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-201117"},{"key":"2025110101585622000_384.jan17_6.e070856.63","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223357"},{"key":"2025110101585622000_384.jan17_6.e070856.64","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212825"},{"key":"2025110101585622000_384.jan17_6.e070856.65","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq242"},{"key":"2025110101585622000_384.jan17_6.e070856.66","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbspin.2016.02.028"},{"key":"2025110101585622000_384.jan17_6.e070856.67","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.151043"},{"key":"2025110101585622000_384.jan17_6.e070856.68","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203341"},{"key":"2025110101585622000_384.jan17_6.e070856.69","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008794.pub2"},{"key":"2025110101585622000_384.jan17_6.e070856.70","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kead515"},{"key":"2025110101585622000_384.jan17_6.e070856.71","doi-asserted-by":"publisher","DOI":"10.1002\/art.23059"},{"key":"2025110101585622000_384.jan17_6.e070856.72","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-eular.2252"},{"key":"2025110101585622000_384.jan17_6.e070856.73","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key023"},{"key":"2025110101585622000_384.jan17_6.e070856.74","doi-asserted-by":"publisher","DOI":"10.1002\/art.21978"},{"key":"2025110101585622000_384.jan17_6.e070856.75","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu172"},{"key":"2025110101585622000_384.jan17_6.e070856.76","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204960"},{"key":"2025110101585622000_384.jan17_6.e070856.77","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(08)70227-5"},{"key":"2025110101585622000_384.jan17_6.e070856.78","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223335"},{"key":"2025110101585622000_384.jan17_6.e070856.79","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0728-9"},{"key":"2025110101585622000_384.jan17_6.e070856.80","doi-asserted-by":"publisher","DOI":"10.1186\/ar2751"},{"key":"2025110101585622000_384.jan17_6.e070856.81","doi-asserted-by":"publisher","DOI":"10.1002\/art.21675"},{"key":"2025110101585622000_384.jan17_6.e070856.82","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-021-02325-9"},{"key":"2025110101585622000_384.jan17_6.e070856.83","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24784"},{"key":"2025110101585622000_384.jan17_6.e070856.84","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209285"},{"key":"2025110101585622000_384.jan17_6.e070856.85","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2020.08.007"},{"key":"2025110101585622000_384.jan17_6.e070856.86","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2109927"},{"key":"2025110101585622000_384.jan17_6.e070856.87","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222259"},{"key":"2025110101585622000_384.jan17_6.e070856.88","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223715"},{"key":"2025110101585622000_384.jan17_6.e070856.89","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2022-eular.4585"},{"key":"2025110101585622000_384.jan17_6.e070856.90","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222543"},{"key":"2025110101585622000_384.jan17_6.e070856.91","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222824"},{"key":"2025110101585622000_384.jan17_6.e070856.92","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-221915"},{"key":"2025110101585622000_384.jan17_6.e070856.93","doi-asserted-by":"publisher","DOI":"10.1002\/acr2.11232"},{"key":"2025110101585622000_384.jan17_6.e070856.94","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keq316"},{"key":"2025110101585622000_384.jan17_6.e070856.95","doi-asserted-by":"publisher","DOI":"10.1002\/art.42250"},{"key":"2025110101585622000_384.jan17_6.e070856.96","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001395"},{"key":"2025110101585622000_384.jan17_6.e070856.97","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s40744-022-00505-1","article-title":"Evaluation of VTE, MACE, and serious infections among patients with RA treated with baricitinib compared to TNFi: a multi-database study of patients in routine care using disease registries and claims databases","volume":"10","author":"Salinas","year":"2023","journal-title":"Rheumatol Ther"},{"key":"2025110101585622000_384.jan17_6.e070856.98","unstructured":"European Medicines Agency. EMA confirms measures to minimise risk of serious side effects with Janus kinase inhibitors for chronic inflammatory disorders. EMA, Amserdam, The Netherlands 2023. https:\/\/www.ema.europa.eu\/en\/documents\/referral\/janus-kinase-inhibitors-jaki-article-20-procedure-ema-confirms-measures-minimise-risk-serious-side_en-0.pdf"},{"key":"2025110101585622000_384.jan17_6.e070856.99","unstructured":"Food and Drug Administration. Janus kinase (JAK) inhibitors: drug safety communication - FDA requires warnings about increased risk of serious heart-related events, cancer, blood clots, and death. FDA, 2021. https:\/\/www.fda.gov\/safety\/medical-product-safety-information\/janus-kinase-jak-inhibitors-drug-safety-communication-fda-requires-warnings-about-increased-risk"},{"key":"2025110101585622000_384.jan17_6.e070856.100","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-223443"},{"key":"2025110101585622000_384.jan17_6.e070856.101","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22618"},{"key":"2025110101585622000_384.jan17_6.e070856.102","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209272"},{"key":"2025110101585622000_384.jan17_6.e070856.103","doi-asserted-by":"publisher","DOI":"10.1002\/acr.24253"},{"key":"2025110101585622000_384.jan17_6.e070856.104","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213731"},{"key":"2025110101585622000_384.jan17_6.e070856.105","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217344"},{"key":"2025110101585622000_384.jan17_6.e070856.106","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac190"},{"key":"2025110101585622000_384.jan17_6.e070856.107","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-213378"},{"key":"2025110101585622000_384.jan17_6.e070856.108","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105064"},{"key":"2025110101585622000_384.jan17_6.e070856.109","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-203993"},{"key":"2025110101585622000_384.jan17_6.e070856.110","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez049"},{"key":"2025110101585622000_384.jan17_6.e070856.111","doi-asserted-by":"publisher","DOI":"10.3109\/s10165-010-0402-7"},{"key":"2025110101585622000_384.jan17_6.e070856.112","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220973"},{"key":"2025110101585622000_384.jan17_6.e070856.113","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu358"},{"key":"2025110101585622000_384.jan17_6.e070856.114","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S204730"},{"key":"2025110101585622000_384.jan17_6.e070856.115","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/key207"},{"key":"2025110101585622000_384.jan17_6.e070856.116","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-015-0716-0"},{"key":"2025110101585622000_384.jan17_6.e070856.117","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab107"},{"key":"2025110101585622000_384.jan17_6.e070856.118","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003296"},{"key":"2025110101585622000_384.jan17_6.e070856.119","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2014.10.016"},{"key":"2025110101585622000_384.jan17_6.e070856.120","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keu217"},{"key":"2025110101585622000_384.jan17_6.e070856.121","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.130902"},{"key":"2025110101585622000_384.jan17_6.e070856.122","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2006.057497"},{"key":"2025110101585622000_384.jan17_6.e070856.123","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208941"},{"key":"2025110101585622000_384.jan17_6.e070856.124","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4205"},{"key":"2025110101585622000_384.jan17_6.e070856.125","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21362"},{"key":"2025110101585622000_384.jan17_6.e070856.126","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210453"},{"key":"2025110101585622000_384.jan17_6.e070856.127","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21249"},{"key":"2025110101585622000_384.jan17_6.e070856.128","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209646"},{"key":"2025110101585622000_384.jan17_6.e070856.129","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-022-00845-w"},{"key":"2025110101585622000_384.jan17_6.e070856.130","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.175. PubMed PMID: 27784891."},{"key":"2025110101585622000_384.jan17_6.e070856.131","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215751"},{"key":"2025110101585622000_384.jan17_6.e070856.132","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32341-2"},{"key":"2025110101585622000_384.jan17_6.e070856.133","doi-asserted-by":"publisher","DOI":"10.1002\/art.40810"},{"key":"2025110101585622000_384.jan17_6.e070856.134","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kez411"},{"key":"2025110101585622000_384.jan17_6.e070856.135","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-86729-7"},{"key":"2025110101585622000_384.jan17_6.e070856.136","doi-asserted-by":"publisher","DOI":"10.1080\/1744666X.2020.1771183"},{"key":"2025110101585622000_384.jan17_6.e070856.137","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2020-001220"},{"key":"2025110101585622000_384.jan17_6.e070856.138","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2019.06.009"},{"key":"2025110101585622000_384.jan17_6.e070856.139","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2014-206439"},{"key":"2025110101585622000_384.jan17_6.e070856.140","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.4542"},{"key":"2025110101585622000_384.jan17_6.e070856.141","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab902"},{"key":"2025110101585622000_384.jan17_6.e070856.142","doi-asserted-by":"publisher","DOI":"10.1080\/03009742.2021.1955467"},{"key":"2025110101585622000_384.jan17_6.e070856.143","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keac515"},{"key":"2025110101585622000_384.jan17_6.e070856.144","first-page":"126","article-title":"Can biomarkers predict successful tapering of conventional disease-modifying therapy in rheumatoid arthritis patients in stable remission?","volume":"41","author":"Gul","year":"2023","journal-title":"Clin Exp Rheumatol"},{"key":"2025110101585622000_384.jan17_6.e070856.145","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2022-002796"},{"key":"2025110101585622000_384.jan17_6.e070856.146","doi-asserted-by":"publisher","DOI":"10.1002\/art.24661"},{"key":"2025110101585622000_384.jan17_6.e070856.147","doi-asserted-by":"publisher","DOI":"10.1002\/art.20018"},{"key":"2025110101585622000_384.jan17_6.e070856.148","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2011-200990"},{"key":"2025110101585622000_384.jan17_6.e070856.149","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(22)01193-X"},{"key":"2025110101585622000_384.jan17_6.e070856.150","unstructured":"Rech JKA \u00d8stergaard M Hagen M . Abatacept significantly reduces subclinical inflammation during treatment (6 months), this persists after discontinuation (12 months), resulting in a delay in the clinical development of RA in patients at risk of RA (the ARIAA study). Arthritis Rheumatol 2022:74."},{"key":"2025110101585622000_384.jan17_6.e070856.151","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2017-212763"},{"key":"2025110101585622000_384.jan17_6.e070856.152","unstructured":"Deane KSC Feser M Demoruelle K . Hydroxychloroquine does not prevent the future development of rheumatoid arthritis in a population with baseline high levels of antibodies to citrullinated protein antigens and absence of inflammatory arthritis: interim analysis of the StopRA trial. Arthritis Rheumatol 2022:74."},{"key":"2025110101585622000_384.jan17_6.e070856.153","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.105767"},{"key":"2025110101585622000_384.jan17_6.e070856.154","doi-asserted-by":"publisher","DOI":"10.1186\/s13063-019-3403-7"},{"key":"2025110101585622000_384.jan17_6.e070856.155","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220884"},{"key":"2025110101585622000_384.jan17_6.e070856.156","doi-asserted-by":"publisher","DOI":"10.1084\/jem.192.7.1027"},{"key":"2025110101585622000_384.jan17_6.e070856.157","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2209856"},{"key":"2025110101585622000_384.jan17_6.e070856.158","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214229"},{"key":"2025110101585622000_384.jan17_6.e070856.159","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1263-7"},{"key":"2025110101585622000_384.jan17_6.e070856.160","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(21)00061-8"},{"key":"2025110101585622000_384.jan17_6.e070856.161","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2015-208456"},{"key":"2025110101585622000_384.jan17_6.e070856.162","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aaa9301"},{"key":"2025110101585622000_384.jan17_6.e070856.163","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215882"},{"key":"2025110101585622000_384.jan17_6.e070856.164","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215458"},{"key":"2025110101585622000_384.jan17_6.e070856.165","doi-asserted-by":"publisher","DOI":"10.1136\/ard-2022-222678"},{"key":"2025110101585622000_384.jan17_6.e070856.166","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2021-220249"},{"key":"2025110101585622000_384.jan17_6.e070856.167","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-005-1155-0"},{"key":"2025110101585622000_384.jan17_6.e070856.168","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f1939"},{"key":"2025110101585622000_384.jan17_6.e070856.169","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204603"},{"key":"2025110101585622000_384.jan17_6.e070856.170","doi-asserted-by":"publisher","DOI":"10.1038\/nature20810"},{"key":"2025110101585622000_384.jan17_6.e070856.171","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.15661"},{"key":"2025110101585622000_384.jan17_6.e070856.172","unstructured":"National Institute for Health and Care Excellence. Adalimumab, etanercept, infliximab and abatacept for treating moderate rheumatoid arthritis after conventional DMARDs have failed. London, NICE: TA715. 2021. https:\/\/www.nice.org.uk\/guidance\/ta715"},{"key":"2025110101585622000_384.jan17_6.e070856.173","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD003785"},{"key":"2025110101585622000_384.jan17_6.e070856.174","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD004525.pub2"},{"issue":"3","key":"2025110101585622000_384.jan17_6.e070856.175","article-title":"Adalimumab for treating rheumatoid arthritis","author":"Navarro-Sarabia","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.176","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.013052"},{"key":"2025110101585622000_384.jan17_6.e070856.177","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD008341"},{"key":"2025110101585622000_384.jan17_6.e070856.178","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099010"},{"key":"2025110101585622000_384.jan17_6.e070856.179","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60506-7"},{"key":"2025110101585622000_384.jan17_6.e070856.180","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD007649.pub4"},{"key":"2025110101585622000_384.jan17_6.e070856.181","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.099291"},{"issue":"1","key":"2025110101585622000_384.jan17_6.e070856.182","article-title":"Anakinra for rheumatoid arthritis","author":"Mertens","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.183","article-title":"Rituximab for rheumatoid arthritis","volume":"1","author":"Lopez-Olivo","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.184","doi-asserted-by":"publisher","DOI":"10.1002\/art.22025"},{"key":"2025110101585622000_384.jan17_6.e070856.185","article-title":"Abatacept for rheumatoid arthritis","volume":"2009","author":"Maxwell","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.186","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050524"},{"issue":"7","key":"2025110101585622000_384.jan17_6.e070856.187","article-title":"Tocilizumab for rheumatoid arthritis","author":"Singh","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"key":"2025110101585622000_384.jan17_6.e070856.188","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.092932"},{"key":"2025110101585622000_384.jan17_6.e070856.189","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-1096-9"},{"key":"2025110101585622000_384.jan17_6.e070856.190","doi-asserted-by":"publisher","DOI":"10.1002\/art.39944"},{"key":"2025110101585622000_384.jan17_6.e070856.191","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61424-X"},{"key":"2025110101585622000_384.jan17_6.e070856.192","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1109071"},{"key":"2025110101585622000_384.jan17_6.e070856.193","doi-asserted-by":"publisher","DOI":"10.1002\/art.40803"},{"key":"2025110101585622000_384.jan17_6.e070856.194","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2018-214529"},{"key":"2025110101585622000_384.jan17_6.e070856.195","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kex489"},{"key":"2025110101585622000_384.jan17_6.e070856.196","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215764"},{"key":"2025110101585622000_384.jan17_6.e070856.197","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31116-4"},{"key":"2025110101585622000_384.jan17_6.e070856.198","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-210105"},{"key":"2025110101585622000_384.jan17_6.e070856.199","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.9055"},{"key":"2025110101585622000_384.jan17_6.e070856.200","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-219214"},{"key":"2025110101585622000_384.jan17_6.e070856.201","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.2929"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj-2022-070856","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj-2022-070856","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T08:59:04Z","timestamp":1761987544000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj-2022-070856"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,17]]},"references-count":201,"alternative-id":["10.1136\/bmj-2022-070856"],"URL":"https:\/\/doi.org\/10.1136\/bmj-2022-070856","relation":{},"ISSN":["1756-1833"],"issn-type":[{"value":"1756-1833","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,1,17]]}}}