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Non-purulent SSTI is most commonly associated with beta-haemolytic streptococci, while purulent SSTI is typically associated with\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    . Cellulitis most commonly presents with acute warmth, pain, tenderness to palpation, erythema, and oedema. Skin abscess typically presents with a fluctuant tender area with erythema. Laboratory testing is of limited use in most patients. Point-of-care ultrasound is useful for distinguishing cellulitis from abscess if the diagnosis is unclear. Management of SSTI includes antibiotics such as penicillin VK, dicloxacillin, or a cephalosporin, while treatment for skin abscess includes incision and drainage, with antibiotics recommended in select patients. Patients should elevate the affected extremity when possible, and non-steroidal anti-inflammatory drugs may reduce pain and inflammation. The effectiveness of decolonization for patients with recurrent cellulitis or skin abscess is controversial. While most patients with cellulitis or skin abscess are appropriate for discharge with follow-up, patients with sepsis and those with challenges adhering to therapy, immunosuppression, or failed outpatient therapy should be referred to the emergency department. Novel antibiotics such as tedizolid, delafloxacin, omadacycline, and ceftaroline may be considered in select cases.\n                  <\/jats:p>","DOI":"10.1136\/bmj-2026-100580","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T12:10:15Z","timestamp":1789128615000},"page":"e100580","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Advances in the diagnosis and management of skin and soft tissue infections"],"prefix":"10.1136","volume":"394","author":[{"given":"Brit","family":"Long","sequence":"first","affiliation":[{"name":"Emergency Medicine, Mayo Clinic Rochester, Rochester, Minnesota, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krishan","family":"Yadav","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Ottawa Hospital, Ottawa, Ontario K1Y4E9, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan A","family":"Rech","sequence":"additional","affiliation":[{"name":"Edward Hines Jr VA Hospital, Hines, Illinois 60141, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gottlieb","sequence":"additional","affiliation":[{"name":"Emergency Medicine, Rush University Medical Center, Chicago, Illinois 60612-3801, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2026,9,10]]},"reference":[{"key":"2026091109000742000_394.sep10_11.e100580.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annemergmed.2007.12.004"},{"key":"2026091109000742000_394.sep10_11.e100580.2","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cis342"},{"key":"2026091109000742000_394.sep10_11.e100580.3","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz977"},{"key":"2026091109000742000_394.sep10_11.e100580.4","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1071-0"},{"key":"2026091109000742000_394.sep10_11.e100580.5","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.168.14.1585"},{"key":"2026091109000742000_394.sep10_11.e100580.6","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000239"},{"key":"2026091109000742000_394.sep10_11.e100580.7","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir308"},{"key":"2026091109000742000_394.sep10_11.e100580.8","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciy509"},{"key":"2026091109000742000_394.sep10_11.e100580.9","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.861115"},{"key":"2026091109000742000_394.sep10_11.e100580.10","doi-asserted-by":"publisher","DOI":"10.1093\/ofid\/ofae267"},{"key":"2026091109000742000_394.sep10_11.e100580.11","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2023.1145513"},{"key":"2026091109000742000_394.sep10_11.e100580.12","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.8825"},{"key":"2026091109000742000_394.sep10_11.e100580.13","first-page":"2207","article-title":"Cellulitis and erysipelas","author":"Morris","year":"2006","journal-title":"Clin Evid"},{"key":"2026091109000742000_394.sep10_11.e100580.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jemermed.2021.09.015"},{"key":"2026091109000742000_394.sep10_11.e100580.15","doi-asserted-by":"publisher","DOI":"10.1007\/s43678-024-00754-9"},{"key":"2026091109000742000_394.sep10_11.e100580.16","doi-asserted-by":"publisher","DOI":"10.1007\/s43678-024-00739-8"},{"key":"2026091109000742000_394.sep10_11.e100580.17","doi-asserted-by":"publisher","DOI":"10.3947\/ic.2017.49.4.301"},{"key":"2026091109000742000_394.sep10_11.e100580.18","doi-asserted-by":"publisher","DOI":"10.1186\/1749-7922-9-57"},{"key":"2026091109000742000_394.sep10_11.e100580.19","doi-asserted-by":"publisher","DOI":"10.1186\/s13017-022-00406-2"},{"key":"2026091109000742000_394.sep10_11.e100580.20","unstructured":"Clinical Resource Efficiency Support Team (CREST). 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