{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T21:29:09Z","timestamp":1768339749819,"version":"3.49.0"},"reference-count":0,"publisher":"BMJ","issue":"5801","license":[{"start":{"date-parts":[[1972,3,11]],"date-time":"1972-03-11T00:00:00Z","timestamp":69120000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1972,3,11]]},"abstract":"<jats:p>Four consecutive patients with megaloblastic anaemia who also received therapy with trimethoprim-sulphamethoxazole all showed poor responses to specific haematinic therapy. This was attributed to trimethoprim, which suppressed reticulocyte responses in three cases and produced a pancytopenia in two and a falling haemoglobin with neutropenia in a third. A fourth patient, with pernicious anaemia, had a satisfactory reticulocyte response but experienced no clinical benefit until after withdrawal of trimethoprim.<\/jats:p>\n                  <jats:p>Trimethoprim seems not to be a safe form of therapy in patients with a megaloblastic process; many of the toxic reactions reported with this drug may be on the basis of an unrecognized megaloblastic form of haemopoiesis.<\/jats:p>","DOI":"10.1136\/bmj.1.5801.651","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"651-653","source":"Crossref","is-referenced-by-count":49,"title":["Toxicity of Trimethoprim-Sulphamethoxazole in Patients with Megaloblastic Haemopoiesis"],"prefix":"10.1136","volume":"1","author":[{"given":"I.","family":"Chanarin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. M.","family":"England","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,3,11]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.1.5801.651","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.1.5801.651","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T22:01:18Z","timestamp":1763330478000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.1.5801.651"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,3,11]]},"references-count":0,"journal-issue":{"issue":"5801","published-online":{"date-parts":[[1972,3,11]]},"published-print":{"date-parts":[[1972,3,11]]}},"alternative-id":["10.1136\/bmj.1.5801.651"],"URL":"https:\/\/doi.org\/10.1136\/bmj.1.5801.651","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1972,3,11]]}}}