{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:47:15Z","timestamp":1770508035026,"version":"3.49.0"},"reference-count":0,"publisher":"BMJ","issue":"5847","license":[{"start":{"date-parts":[[1973,1,27]],"date-time":"1973-01-27T00:00:00Z","timestamp":96940800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1973,1,27]]},"abstract":"<jats:p>\n                    The influence on airway conductance of inhaled aerosols of prostaglandin F\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 (PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1), histamine, and prostaglandin E\n                    <jats:sub>2<\/jats:sub>\n                    (PGE\n                    <jats:sub>2<\/jats:sub>\n                    ) was studied in 10 patients with spirometrically reversible bronchial asthma and in 10 healthy subjects with no history of lung disorder. Both groups responded with bronchoconstriction after inhalation of PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 but the asthmatic patients were about 8,000 times more sensitive to the compound than were the healthy controls. In the patients, but not in the controls, PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 often caused a long-standing decrease in airway conductance with symptoms resembling allergen-provoked asthmatic attacks. On the other hand, the patients showed less than a 10-fold increase in sensitivity to histamine, and the ratio of histamine: PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 doses causing a 50% decrease of airway conductance was 2\u00b76:1 and 2,400:1 in controls and patients respectively. Inhalation of PGE\n                    <jats:sub>2<\/jats:sub>\n                    while moderately but consistently increasing airway conductance in controls, had a variable\u2014occasionally slight bronchoconstrictive\u2014effect in patients. The decrease in airway conductance by a given dose of PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 was little modified by the simultaneous inhalation of a 100-times higher PGE\n                    <jats:sub>2<\/jats:sub>\n                    dose. It is suggested that endogenous, locally formed PGF\n                    <jats:sub>2<\/jats:sub>\n                    \u03b1 may play an important part in the pathogenesis of bronchial asthma.\n                  <\/jats:p>","DOI":"10.1136\/bmj.1.5847.193","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"193-196","source":"Crossref","is-referenced-by-count":175,"title":["Bronchial Hyperreactivity to Prostaglandin F2\u03b1 and Histamine in Patients with Asthma"],"prefix":"10.1136","volume":"1","author":[{"given":"A. A.","family":"Math\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Hedqvist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Holmgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Svanborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1973,1,27]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.1.5847.193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.1.5847.193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T22:31:38Z","timestamp":1763332298000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.1.5847.193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,1,27]]},"references-count":0,"journal-issue":{"issue":"5847","published-online":{"date-parts":[[1973,1,27]]},"published-print":{"date-parts":[[1973,1,27]]}},"alternative-id":["10.1136\/bmj.1.5847.193"],"URL":"https:\/\/doi.org\/10.1136\/bmj.1.5847.193","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,1,27]]}}}