{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T10:48:13Z","timestamp":1790419693947,"version":"4.1.0"},"reference-count":0,"publisher":"BMJ","issue":"5852","license":[{"start":{"date-parts":[[1973,3,3]],"date-time":"1973-03-03T00:00:00Z","timestamp":99964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1973,3,3]]},"abstract":"<jats:p>The minimum number of IgG anti-A (or anti-B) molecules detectable on A or B red cells by the antiglobulin reaction was found to be the same\u2014that is, about 150 molecules per red cell\u2014with newborn as with adult cells. Furthermore, the ratio of anti-IgG bound to IgG anti-A (or anti-B) molecules was the same whether the anti-A (or anti-B) molecules were present on newborn or on adult cells and was similar to that found for anti-IgG bound to IgG anti-Rh.<\/jats:p>\n                  <jats:p>In 15 infants (11 group A, 4 group B) with haemolytic disease of the newborn due to ABO-incompatibility the amount of anti-A or anti-B on the red cells ranged from 0\u00b725 to 3\u00b75 \u03bcg antibody per ml red cells, corresponding to 90-1,320 antibody molecules per cell; only five infants had more than 0\u00b755 \u03bcg antibody per ml of red cells. These amounts are far smaller than those found in most moderate or severe cases of Rh-haemolytic disease.<\/jats:p>\n                  <jats:p>It is concluded that the weak direct antiglobulin reactions observed in ABO-haemolytic disease are due simply to the fact that the number of anti-A (or anti-B) molecules on the infant's red cells is at the lower limit of sensitivity of the test. Since ABO-haemolytic disease can be quite a severe process it seems probable that IgG anti-A and anti-B molecules are more effective than anti-Rh molecules in bringing about red cell destruction.<\/jats:p>","DOI":"10.1136\/bmj.1.5852.524","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"524-526","source":"Crossref","is-referenced-by-count":43,"title":["Direct Antiglobulin Reaction in ABO-Haemolytic Disease of the Newborn"],"prefix":"10.1136","volume":"1","author":[{"given":"E. L.","family":"Romano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N. C.","family":"Hughes-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"Mollison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1973,3,3]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.1.5852.524","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.1.5852.524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T22:55:52Z","timestamp":1763333752000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.1.5852.524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,3,3]]},"references-count":0,"journal-issue":{"issue":"5852","published-online":{"date-parts":[[1973,3,3]]},"published-print":{"date-parts":[[1973,3,3]]}},"alternative-id":["10.1136\/bmj.1.5852.524"],"URL":"https:\/\/doi.org\/10.1136\/bmj.1.5852.524","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,3,3]]}}}