{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T10:24:18Z","timestamp":1791973458141,"version":"4.4.0"},"reference-count":0,"publisher":"BMJ","issue":"5854","license":[{"start":{"date-parts":[[1973,3,17]],"date-time":"1973-03-17T00:00:00Z","timestamp":101174400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1973,3,17]]},"abstract":"<jats:p>\n                    Vitamin D deficiency is a previously unreported complication of therapy with hypnotics, and we here report a case of osteomalacia associated with long-term glutethimide administration. There was evidence of pronounced hepatic enzyme induction, and the plasma half-time of\n                    <jats:sup>3<\/jats:sup>\n                    H vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    was decreased by this drug. In addition, raised levels of serum gamma-glutamyl transpeptidase, 5-nucleotidase, and leucine aminopeptidase were observed and the patient excreted large amounts of xylulose. These changes were reversed by stopping the glutethimide.\n                  <\/jats:p>","DOI":"10.1136\/bmj.1.5854.643","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"643-645","source":"Crossref","is-referenced-by-count":32,"title":["Osteomalacia after Prolonged Glutethimide Administration"],"prefix":"10.1136","volume":"1","author":[{"given":"R. H.","family":"Greenwood","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F. T. G.","family":"Prunty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Silver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1973,3,17]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.1.5854.643","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.1.5854.643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,16]],"date-time":"2025-11-16T23:04:49Z","timestamp":1763334289000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.1.5854.643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1973,3,17]]},"references-count":0,"journal-issue":{"issue":"5854","published-online":{"date-parts":[[1973,3,17]]},"published-print":{"date-parts":[[1973,3,17]]}},"alternative-id":["10.1136\/bmj.1.5854.643"],"URL":"https:\/\/doi.org\/10.1136\/bmj.1.5854.643","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1973,3,17]]}}}