{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T19:40:23Z","timestamp":1764963623032,"version":"3.46.0"},"reference-count":0,"publisher":"BMJ","issue":"5804","license":[{"start":{"date-parts":[[1972,4,1]],"date-time":"1972-04-01T00:00:00Z","timestamp":70934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1972,4,1]]},"abstract":"<jats:p>Glomerular filtration rate and renal plasma flow were simultaneously determined in comparable groups of 43 diabetics less than 40 years of age and with a duration of diabetes less than 10 years and 32 control subjects. The average glomerular filtration rate in the diabetic group was significantly higher than that in the control group (P &lt;0\u00b701). The average renal plasma flow in the diabetic group was found to be significantly lower than that in the control group (P &lt;0\u00b705). The filtration fraction in both male and female diabetics was significantly higher than in the male and female control groups (P &lt;0\u00b7001). These changes were found to be present even in recent juvenile diabetics with disease of a duration of less than one year. No correlation was apparent between the average levels of serum growth hormone and glomerular filtration rate.<\/jats:p>\n                  <jats:p>The urinary protein excretion was determined in 36 diabetic and 38 healthy subjects comparable with regard to glomerular filtration rate. In the diabetic group there was a greater frequency of cases with higher protein excretion rates (P &lt;0\u00b702). The average protein excretion rate was increased even in diabetics with less than one year's duration of the disease.<\/jats:p>\n                  <jats:p>The results of the changes in renal haemodynamics in subjects with recent and short-term diabetes are compatible with the presence of a constrictive state of the vas efferens leading to an increase in the filtration pressure. The increase in protein excretion rate may similarly be a consequence of this process or of an increase in the glomerular permeability with augmented molecular sieving of proteins or both.<\/jats:p>","DOI":"10.1136\/bmj.2.5804.13","type":"journal-article","created":{"date-parts":[[2009,4,8]],"date-time":"2009-04-08T15:21:07Z","timestamp":1239204067000},"page":"13-19","source":"Crossref","is-referenced-by-count":106,"title":["Abnormal Glomerular Filtration Rate, Renal Plasma Flow, and Renal Protein Excretion in Recent and Short-term Diabetics"],"prefix":"10.1136","volume":"2","author":[{"given":"J.","family":"Ditzel","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Junker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1972,4,1]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.2.5804.13","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.2.5804.13","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T19:22:52Z","timestamp":1764962572000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.2.5804.13"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1972,4,1]]},"references-count":0,"journal-issue":{"issue":"5804","published-online":{"date-parts":[[1972,4,1]]},"published-print":{"date-parts":[[1972,4,1]]}},"alternative-id":["10.1136\/bmj.2.5804.13"],"URL":"https:\/\/doi.org\/10.1136\/bmj.2.5804.13","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1972,4,1]]}}}