{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:41:38Z","timestamp":1765395698576,"version":"3.46.0"},"reference-count":0,"publisher":"BMJ","issue":"6151","license":[{"start":{"date-parts":[[1978,12,2]],"date-time":"1978-12-02T00:00:00Z","timestamp":281404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1978,12,2]]},"abstract":"<jats:p>A simple test was devised to identify people susceptible to chlorpropamide-alcohol flushing (CPAF). Subjects were given a placebo tablet, followed by sherry 12 and 36 hours later. They then received a chlorpropamide tablet and sherry again after 12 and 36 hours. This single-dose challenge test was given to non-insulin-dependent diabetics, insulin-dependent diabetics, and normal subjects. CPAF was common in the non-insulin-dependent diabetics but rare in the other groups. When the test was used in identical twins and families of affected subjects CPAF appeared to be a dominantly inherited trait. We conclude that facial flushing after alcohol in people taking chlorpropamide is related to non-insulin-dependent diabetes, especially when there is a strong family history of diabetes, but not to insulin-dependent diabetes. It is a dominantly inherited trait.<\/jats:p>","DOI":"10.1136\/bmj.2.6151.1519","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1519-1521","source":"Crossref","is-referenced-by-count":100,"title":["Chlorpropamide-alcohol flushing: a dominantly inherited trait associated with diabetes."],"prefix":"10.1136","volume":"2","author":[{"given":"R D","family":"Leslie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Pyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1978,12,2]]},"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.2.6151.1519","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.2.6151.1519","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:37:24Z","timestamp":1765395444000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.2.6151.1519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,12,2]]},"references-count":0,"journal-issue":{"issue":"6151","published-online":{"date-parts":[[1978,12,2]]},"published-print":{"date-parts":[[1978,12,2]]}},"alternative-id":["10.1136\/bmj.2.6151.1519"],"URL":"https:\/\/doi.org\/10.1136\/bmj.2.6151.1519","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1978,12,2]]}}}