{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T12:50:39Z","timestamp":1765543839056,"version":"3.48.0"},"reference-count":30,"publisher":"BMJ","issue":"6210","license":[{"start":{"date-parts":[[1980,2,2]],"date-time":"1980-02-02T00:00:00Z","timestamp":318297600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,2,2]]},"abstract":"<jats:p>Randomised, double-blind cross-over trials were performed in seven anephric patients to determine the effect of the orally active angiotensin-converting enzyme inhibitor captopril on blood pressure in fluid-depleted and fluid-replete patients. Patients were given captopril, 100 mg orally, or placebo one hour after haemodialysis, when they were fluid depleted. Their mean (+\/- SEM) supine blood pressure fell from 127 +\/- 12\/71 +\/- 6 mm Hg before captopril to 106 +\/- 13\/54 +\/- 4 mm Hg 24 hours after the drug, while on placebo it rose from 123 +\/- 11\/73 +\/- 5 mm Hg to 134 +\/- 10\/82 +\/- 8 mm Hg. All patients developed orthostatic hypotension after captopril. In the fluid-replete state, two days after haemodialysis, captopril had no effect on blood pressure. The plasma concentration of active renin was extremely low and did not rise after fluid withdrawal or captopril. Thus the hypotensive effect of captopril did not appear to depend on circulating renin concentrations. The concept of \"renin-dependent\" hypertension, which is responsive to captopril, as opposed to \"volume-dependent\" hypertension, which is not responsive to captopril, may therefore be invalid.<\/jats:p>","DOI":"10.1136\/bmj.280.6210.288","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"288-290","source":"Crossref","is-referenced-by-count":57,"title":["Effects of an angiotensin-converting enzyme inhibitor (captopril) on blood pressure in anephric subjects."],"prefix":"10.1136","volume":"280","author":[{"given":"A J","family":"Man in 't Veld","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I M","family":"Schicht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F H","family":"Derkx","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"de Bruyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A","family":"Schalekamp","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,2,2]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1161\/01.RES.36.2.247","article-title":"Angiotensin I converting enzyme","volume":"36","author":"Erdos, E.G.","year":"1975","unstructured":"Erdos EG. Angiotensin I converting enzyme. Circ Res 1975;36:247-55.","journal-title":"Circ Res"},{"key":"ref_2","first-page":"248","article-title":"Design of specific inhibitors of angiotensin-converting enzyme: a new class of orally 'active antihypertensive agents","volume":"196","author":"Ondetti, M.A.; Rubin, B.; Cushman, D.W.","year":"1977","unstructured":"Ondetti MA, Rubin B, Cushman DW. Design of specific inhibitors of angiotensin-converting enzyme: a new class of orally 'active antihypertensive agents. Science 1977;196:248-50.","journal-title":"Science"},{"key":"ref_3","first-page":"1049","article-title":"Antihypertensive activity of SQ 14.225, an orally active inhibitor of","volume-title":"angiotensin-converting enzyme. Fed Proc","volume":"36","author":"Laffan, R.J.; Goldberg, M.E.; High, J.P.; Schaeffer, T.; Waugh, M.H.; Rubin, B.","year":"1977","unstructured":"Laffan RJ, Goldberg ME, High JP, Schaeffer T, Waugh MH, Rubin B. Antihypertensive activity of SQ 14.225, an orally active inhibitor of angiotensin-converting enzyme. Fed Proc 1977;36:1049."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0014-2999(78)90429-6","article-title":"Chronic anti-hypertensive effect of captopril (SQ 14.225), an orally active angiotensin I-converting enzyme inhibitor in conscious 2-kidney renal hypertensive rats","volume":"51","author":"Rubin, B.; Antanaccio, M.J.; Goldberg, M.E.","year":"1978","unstructured":"Rubin B, Antanaccio MJ, Goldberg ME, et al. Chronic anti-hypertensive effect of captopril (SQ 14.225), an orally active angiotensin I-converting enzyme inhibitor in conscious 2-kidney renal hypertensive rats. Eur J Pharmacol 1978;51:377-88.","journal-title":"Eur J Pharmacol"},{"issue":"21","key":"ref_5","first-page":"183","article-title":"Captopril (SQ 14.225) (D-3Mercapto-2-Methylpropanoyl-L-Proline). 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Physiol Pharmacol"},{"key":"ref_25","first-page":"299","article-title":"Blood-pressure response of nephrectomized hypertensive rats to converting enzyme inhibitor: evidence for persisting vascular renin activity","volume":"53","author":"Thurston, H.; Swales, J.D.","year":"1977","unstructured":"Thurston H, Swales JD. Blood-pressure response of nephrectomized hypertensive rats to converting enzyme inhibitor: evidence for persisting vascular renin activity. Clin Sci Mol Med 1977;53:299-304.","journal-title":"Clin Sci Mol Med"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1093\/oxfordjournals.bmb.a071479","article-title":"Surface-mediated reactions in the formation of thrombin, plasmin and kallikrein","volume":"34","author":"Ogston, D.; Bennett, B.","year":"1978","unstructured":"Ogston D, Bennett B. Surface-mediated reactions in the formation of thrombin, plasmin and kallikrein. 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Lancet 1979;i: 1213-5.","journal-title":"Lancet"},{"key":"ref_29","first-page":"1048","article-title":"Hyperbradykininism. A new orthostatic syndrome","volume":"ii:","author":"Straeten, D.H.P.; Kerr, L.P.; Kerr, C.B.; Prior, J.C.; Dalakos, T.G.","year":"1972","unstructured":"Straeten DHP, Kerr LP, Kerr CB, Prior JC, Dalakos TG. Hyperbradykininism. A new orthostatic syndrome. 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