{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:01:40Z","timestamp":1765393300777,"version":"3.46.0"},"reference-count":19,"publisher":"BMJ","issue":"6211","license":[{"start":{"date-parts":[[1980,2,9]],"date-time":"1980-02-09T00:00:00Z","timestamp":318902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,2,9]]},"abstract":"<jats:p>A total of 184 six-month periods were analysed during which feverish illnesses occurred in children aged 6-42 months with a history of a febrile convulsion. Fits occurred in 34 out of 100 such periods when no treatment was being given, in six out of 45 periods when the serum phenobarbitone concentration was 69.0 mumol\/l (1.6 mg\/100 ml) or more, and in five out of 39 periods when the plasma valproic acid concentration was 416.4 mumol\/l (6.0 mg\/100 ml) or more. Thus in adequate dosage both phenobarbitone and valproic acid were significantly better than no treatment in preventing febrile convulsions (p less than 0.02). The two drugs were of comparable efficacy. It is concluded that with improved compliance valproic acid, which is relatively free from side effects, might be an effective prophylactic agent against febrile convulsions.<\/jats:p>","DOI":"10.1136\/bmj.280.6211.353","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"353-354","source":"Crossref","is-referenced-by-count":55,"title":["Successful prophylaxis against febrile convulsions with valproic acid or phenobarbitone."],"prefix":"10.1136","volume":"280","author":[{"given":"S J","family":"Wallace","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,2,9]]},"reference":[{"key":"ref_1","article-title":"Febrile convulsions. A reappraisal","author":"Lennox-Buchthal, M.A.","year":"1973","unstructured":"Lennox-Buchthal MA. Febrile convulsions. A reappraisal. Amsterdam: Elsevier, 1973."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1055\/s-0028-1091518","article-title":"Febrile convulsions followed by non-febrile convulsions","volume":"8","author":"Tsuboi, T.; Endo, S.","year":"1977","unstructured":"Tsuboi T, Endo S. Febrile convulsions followed by non-febrile convulsions. Neuropaediatrie 1977;8:209-33.","journal-title":"Neuropaediatrie"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1528-1157.1974.tb04940.x","article-title":"Studies on convulsive disorders in young children. III. Recurrence of febrile convulsions","volume":"15","author":"den Berg BJ, Van","year":"1974","unstructured":"Van den Berg BJ. Studies on convulsive disorders in young children. III. Recurrence of febrile convulsions. Epilepsia 1974;15:177-90.","journal-title":"Epilepsia"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1136\/adc.52.3.192","article-title":"Spontaneous fits after convulsions with fever","volume":"52","author":"Wallace, S.J.","year":"1977","unstructured":"Wallace SJ. Spontaneous fits after convulsions with fever. Arch Dis Child 1977;52:192-6.","journal-title":"Arch Dis Child"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/j.1469-8749.1979.tb01578.x","article-title":"Long-term psychological outlook in children who have convulsed with fever","volume":"21","author":"Wallace, S.J.; Cull, A.M.","year":"1979","unstructured":"Wallace SJ, Cull AM. Long-term psychological outlook in children who have convulsed with fever. Dev Med Child Neurol 1979;21:28-40.","journal-title":"Dev Med Child Neurol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1542\/peds.61.5.720","article-title":"Prognosis in children with febrile seizures","volume":"61","author":"Nelson, K.B.; Ellenberg, J.H.","year":"1978","unstructured":"Nelson KB, Ellenberg JH. Prognosis in children with febrile seizures. Pediatrics 1978;61:720-7.","journal-title":"Pediatrics"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1136\/adc.49.10.763","article-title":"Recurrence of febrile convulsions","volume":"49","author":"Wallace, S.J.","year":"1974","unstructured":"Wallace SJ. Recurrence of febrile convulsions. Arch Dis Child 1974;49:763-5.","journal-title":"Arch Dis Child"},{"key":"ref_8","first-page":"179","article-title":"Successful prophylaxis of febrile convulsions with phenobarbital","volume":"13","year":"1972","unstructured":"Facro 0, Kastrup KW, Lykkegard Nielsen E, Melchior JC, Thorn I. Successful prophylaxis of febrile convulsions with phenobarbital. Epilepsia 1972;13:179-285.","journal-title":"Epilepsia"},{"key":"ref_9","first-page":"326","article-title":"Comment on treatment of febrile seizures","volume-title":"Year book of pediatrics","author":"Rabe, E.F.","year":"1977","unstructured":"Rabe EF. Comment on treatment of febrile seizures. In: Gellis SS, ed. Year book of pediatrics. Chicago: Year Book Medical Publishers, 1977;326-7."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/j.1600-0404.1975.tb01391.x","article-title":"Continuous prophylactic anticonvulsants in selected children with febrile convulsions","volume":"60","author":"Wallace, S.J.","year":"1975","unstructured":"Wallace SJ. Continuous prophylactic anticonvulsants in selected children with febrile convulsions. Acta Neurol Scand 1975;60,suppl:62-6.","journal-title":"Acta Neurol Scand"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1542\/peds.59.3.378","article-title":"The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study","volume":"59","author":"Wolf, S.M.; Carr, A.; Davis, D.C.","year":"1977","unstructured":"Wolf SM, Carr A, Davis DC, et al. The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study. Pediatrics 1977;59:378-85.","journal-title":"Pediatrics"},{"key":"ref_12","first-page":"559","article-title":"Failure of phenobarbitone to prevent febrile convulsions","volume":"i:","author":"Heckmatt, J.Z.; Houston, A.B.; Clow, D.J.","year":"1976","unstructured":"Heckmatt JZ, Houston AB, Clow DJ, et al. Failure of phenobarbitone to prevent febrile convulsions. Br Med3 1976;i:559-61."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1111\/j.1528-1157.1975.tb04746.x","article-title":"Prevention of febrile convulsions with dipropylacetate (Depakine (R))","volume":"16","author":"Cavazzutti, G.B.","year":"1975","unstructured":"Cavazzutti GB. Prevention of febrile convulsions with dipropylacetate (Depakine (R)). Epilepsia 1975;16:647-8.","journal-title":"Epilepsia"},{"key":"ref_14","first-page":"775","article-title":"A child's first febrile convulsion","volume":"221","author":"Clare, M.; Aldridge-Smith, J.; Wallace, S.J.","year":"1978","unstructured":"Clare M, Aldridge-Smith J, Wallace SJ. A child's first febrile convulsion. Practitioner 1978;221:775-6.","journal-title":"Practitioner"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1136\/bmj.2.6148.1345","article-title":"Febrile convulsions: What do parents do?","volume":"ii:","author":"Rutter, N.; Metcalfe, D.J.","year":"1978","unstructured":"Rutter N, Metcalfe DJ. Febrile convulsions: What do parents do? Br MedJ 1978;ii:1345-6.","journal-title":"Br MedJ"},{"key":"ref_16","first-page":"226","article-title":"Anticonvulsants in the prophylaxis of convulsions with fever: a pilot study","volume-title":"epilepsy and pharmacological prophylaxis","author":"Wallace, S.J.","year":"1977","unstructured":"Wallace SJ. Anticonvulsants in the prophylaxis of convulsions with fever: a pilot study. In Majkowski J, ed. Post-traumatic epilepsy and pharmacological prophylaxis. Warsaw: Polish Chapter of the International League against Epilepsy, 1977:226-32."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1542\/peds.61.5.728","article-title":"Behaviour disturbance, phenobarbital, and febrile seizures","volume":"61","author":"Wolf, S.M.; Forsythe, A.","year":"1978","unstructured":"Wolf SM, Forsythe A. Behaviour disturbance, phenobarbital, and febrile seizures. Pediatrics 1978;61:728-31.","journal-title":"Pediatrics"},{"key":"ref_18","article-title":"The effectiveness of dipropylacetate compared with phenobarbitone or no therapy in the prevention of convulsions with fever","volume-title":"Anti-epileptic therapy, advances in drug mtonitoring","author":"Wallace, S.J.; Aldridge-Smith, J.","unstructured":"Wallace SJ, Aldridge-Smith J. The effectiveness of dipropylacetate compared with phenobarbitone or no therapy in the prevention of convulsions with fever. In: Johannesson SI, Morselli PL, Pippenger CE, Richens A, Schmidt D, Meinardi H, eds. Anti-epileptic therapy, advances in drug mtonitoring. New York: Raven Press (in press)."},{"year":"1979","author":"Accepted","key":"ref_19","unstructured":"(Accepted 7 Novemiber 1979)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6211.353","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6211.353","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:58:08Z","timestamp":1765393088000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6211.353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2,9]]},"references-count":19,"journal-issue":{"issue":"6211","published-online":{"date-parts":[[1980,2,9]]},"published-print":{"date-parts":[[1980,2,9]]}},"alternative-id":["10.1136\/bmj.280.6211.353"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6211.353","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,2,9]]}}}