{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:01:48Z","timestamp":1765393308965,"version":"3.46.0"},"reference-count":30,"publisher":"BMJ","issue":"6211","license":[{"start":{"date-parts":[[1980,2,9]],"date-time":"1980-02-09T00:00:00Z","timestamp":318902400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,2,9]]},"DOI":"10.1136\/bmj.280.6211.369","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"369-371","source":"Crossref","is-referenced-by-count":8,"title":["Hirsutism and virilisation."],"prefix":"10.1136","volume":"280","author":[{"given":"J","family":"Ginsburg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,2,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ajpa.1330150208","article-title":"Variatioin in facial and pubic hair growth in white women","volume":"15","author":"Thomas, P.K.; Ferriman, D.G.","year":"1957","unstructured":"Thomas PK, Ferriman DG. Variatioin in facial and pubic hair growth in white women. Am J Phys Anthropol 1957;15:171-80.","journal-title":"Am J Phys Anthropol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1001\/archderm.1975.01630230098020","article-title":"Testosterone metabolism in the skin","volume":"11","author":"Price, V.H.","year":"1975","unstructured":"Price VH. Testosterone metabolism in the skin. Arch Derrnatol 1975;l11: 1496-1502.","journal-title":"Arch Derrnatol"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1210\/jcem-28-4-479","article-title":"Plasma androgens in patients with the polycystic ovary syndrome","volume":"28","author":"Horton, R.; Neisler, J.","year":"1968","unstructured":"Horton R, Neisler J. Plasma androgens in patients with the polycystic ovary syndrome. 7 Clin Endocrinol 1968;28:479-84.","journal-title":"7 Clin Endocrinol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1111\/j.1365-2265.1975.tb01539.x","article-title":"Chronic treatment regimens for hirsutism in women: effect on blood production rates of testosterone and on hair growth","volume":"4","author":"Casey, J.H.","year":"1975","unstructured":"Casey JH. Chronic treatment regimens for hirsutism in women: effect on blood production rates of testosterone and on hair growth. Clin Endocrinol 1975;4:313-25.","journal-title":"Clin Endocrinol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1210\/jcem-29-10-1356","article-title":"Testosterone and androstenedione metabolism in the polycystic ovary syndrome: studies of the percentage binding of testosterone in plasma","volume":"29","author":"Southren, A.L.; Gordon, G.G.; Tuchimoto, S.; Olivo, J.; Sherman, D.H.; Pinzon, G.","year":"1969","unstructured":"Southren AL, Gordon GG, Tuchimoto S, Olivo J, Sherman DH, Pinzon G. Testosterone and androstenedione metabolism in the polycystic ovary syndrome: studies of the percentage binding of testosterone in plasma J Clin Endocrinol 1969;29:1356-63.","journal-title":"J Clin Endocrinol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2265.1974.tb03298.x","article-title":"Sex-hormone-binding globulin","volume":"3","author":"Anderson, D.C.","year":"1974","unstructured":"Anderson DC. Sex-hormone-binding globulin. Clin Endocrinol 1974;3: 69-96.","journal-title":"Clin Endocrinol"},{"key":"ref_7","first-page":"737","article-title":"Polycystic ovary syndrome. Br MedJ'","volume":"ii:","author":"Ginsburg, J.; Havard, C.W.H.","year":"1976","unstructured":"Ginsburg J, Havard CWH. Polycystic ovary syndrome. Br MedJ' 1976;ii: 737-40."},{"key":"ref_8","first-page":"325","article-title":"The polycystic ovary","volume":"22","author":"Goldzieher, J.W.; Green, J.A.","year":"1962","unstructured":"Goldzieher JW, Green JA. The polycystic ovary. I. Clinical and histologic features. J Clin Endocrinol 1962;22:325-38.","journal-title":"I. Clinical and histologic features. J Clin Endocrinol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1210\/jcem-33-2-199","article-title":"Combined ovarian and adrenal vein catheterization to determine the site(s) of androgen overproduction in hirsute women","volume":"33","author":"Kirschner, M.A.; Jacobs, J.B.","year":"1971","unstructured":"Kirschner MA, Jacobs JB. Combined ovarian and adrenal vein catheterization to determine the site(s) of androgen overproduction in hirsute women. J Clin Endocrinol 1971;33:199-209.","journal-title":"J Clin Endocrinol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/0002-9378(77)90355-6","article-title":"hydroxylase deficiencies in hirsute women","volume":"127","year":"1977","unstructured":";40:988-1000.","journal-title":"Am Y Obstet Gynecol"},{"key":"ref_11","first-page":"373","article-title":"Functional aberrations of the hypothalamic-pituitary system in polycystic ovary syndrome: a consideration of the pathogenesis","volume-title":"The endocrine function of the human ovary","author":"Yen, S.S.C.; Chaney, C.; Judd, H.L.","year":"1976","unstructured":"-hydroxylase deficiencies in hirsute women. Am Y Obstet Gynecol 1977;127:594-8."},{"key":"ref_12","first-page":"877","article-title":"ovarian and adrenal vein steroids in hirsute women: acute effects of human chorionic gonadotropin and adrenocorticotrophic hormone","volume-title":"Fertil Steril","volume":"26","author":"Parker, C.R.; Bruneteau, D.W.; Peripheral, Greenblatt R.B.","year":"1975","unstructured":"Yen SSC, Chaney C, Judd HL. Functional aberrations of the hypothalamic-pituitary system in polycystic ovary syndrome: a consideration of the pathogenesis. In: James VHT, Serio M, Giusti GB, eds. The endocrine function of the human ovary. London: Academic Press, 1976; 373-85."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM197310112891502","article-title":"Testosterone-secreting adrenal adenoma under gonadotropin control","volume":"289","author":"Werk, E.E.; Sholiton, L.J.; Kalejs, L.","year":"1973","unstructured":"Parker CR, Bruneteau DW, Greenblatt RB. Peripheral, ovarian and adrenal vein steroids in hirsute women: acute effects of human chorionic gonadotropin and adrenocorticotrophic hormone. Fertil Steril 1975;26: 877-88.","journal-title":"N Eng J Med"},{"key":"ref_14","first-page":"144","article-title":"Raised serum prolactin levels associated with hirsutism and amenorrhoea. Br MedJ'","volume":"iv:","author":"Seppala, M.; Hirvonen, E.","year":"1975","unstructured":"Werk EE, Sholiton LJ, Kalejs L. Testosterone-secreting adrenal adenoma under gonadotropin control. N Eng J Med 1973;289:767-70."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1365-2265.1977.tb01990.x","article-title":"Plasma androgens in women with hyperprolactinaemic amenorrhoea","volume":"6","author":"Bassi, F.; Guisti, G.; Borsi, L.","year":"1977","unstructured":"Seppala M, Hirvonen E. Raised serum prolactin levels associated with hirsutism and amenorrhoea. Br MedJ' 1975;iv:144-5.","journal-title":"Clin Endocrinol"},{"key":"ref_16","first-page":"665","article-title":"Comparative study of ultrasound, 131 1-19 iodocholesterol scintography, and aortography in localising adrenal lesions","volume":"ii:","author":"Kehlet, H.; Blichert-Toft, M.; Hancke, S.","year":"1976","unstructured":"Bassi F, Guisti G, Borsi L. Plasma androgens in women with hyperprolactinaemic amenorrhoea. Clin Endocrinol 1977;6:5-10.","journal-title":"Br Med J"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0002-9378(74)90184-7","article-title":"Preoperative localization of a testosterone-secreting ovarian tumor by retrograde venous catheterization and selective sampling","volume":"120","author":"Judd, H.G.; Spore, W.W.; Talner, L.B.; Rigg, L.A.; Yen, S.S.C.; Benirschke, K.","year":"1974","unstructured":"Kehlet H, Blichert-Toft M, Hancke S. Comparative study of ultrasound, 131 1-19 iodocholesterol scintography, and aortography in localising adrenal lesions. Br Med J 1976;ii:665-7.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_18","first-page":"100","article-title":"Differential ovarian and adrenal vein catheterization","volume":"125","author":"Weutz, A.C.; White, R.I.; Migeon, C.J.; Hsu, T.H.; Barnes, H.V.; Jones, G.S.","year":"1976","unstructured":"Judd HG, Spore WW, Talner LB, Rigg LA, Yen SSC, Benirschke K. Preoperative localization of a testosterone-secreting ovarian tumor by retrograde venous catheterization and selective sampling. Am J Obstet Gynecol 1974;120:91-6.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0002-9343(73)90223-4","article-title":"Plasma testosterone stimulation-suppression dynamics in hirsute women. Ccrrelation with long term therapy","volume":"54","author":"Ettinger, B.; Goldfield, E.B.; Burrill, K.C.; Von Werder, K.; Forsham, P.H.","year":"1973","unstructured":"Weutz AC, White RI, Migeon CJ, Hsu TH, Barnes HV, Jones GS. Differential ovarian and adrenal vein catheterization. Am J Obstet Gynecol 1976;125:100-7.","journal-title":"Am J Med"},{"key":"ref_20","first-page":"224","article-title":"Effects of hormonal treatment on plasma unbound androgen levels in hirsute women","author":"Anderson, C.D.; Thorner, M.O.; Fisher, R.A.; Woodham, J.P.; Goble, H.L.; Besser, G.M.","year":"1975","unstructured":"Ettinger B, Goldfield EB, Burrill KC, Von Werder K, Forsham PH. Plasma testosterone stimulation-suppression dynamics in hirsute women. Ccrrelation with long term therapy. Am J Med 1973;54:195-200.","journal-title":"Acta Endocrinol Suppl"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/0002-9378(74)90242-7","article-title":"Serum testosterone levels in the polycystic ovary syndrome. Effect of an estrogen-progestin on protein binding of testosterone","volume":"120","author":"Easterling, W.E.; Talbert, L.M.; Potter, H.D.","year":"1974","unstructured":"Anderson CD, Thorner MO, Fisher RA, Woodham JP, Goble HL, Besser GM. Effects of hormonal treatment on plasma unbound androgen levels in hirsute women. Acta Endocrinol Suppl 1975;199:224.","journal-title":"Am 7 Obstet Gynecol"},{"key":"ref_22","first-page":"717","article-title":"Dynamics of suppression and recovery of plasma FSH, LH, androstenedione and testosterone in polycystic ovarian disease using an oral contraceptive","volume":"38","author":"Givens, JR, Andersen; RN, Wiser; WL, Fish; A.S.","year":"1974","unstructured":"Easterling WE, Talbert LM, Potter HD. Serum testosterone levels in the polycystic ovary syndrome. Effect of an estrogen-progestin on protein binding of testosterone. Am 7 Obstet Gynecol 1974;120:385-9.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_23","first-page":"599","article-title":"The treatment of hirsutism with cyproterone acetate","volume":"14","author":"Hammerstein, J.; Cupceancu, B.","year":"1969","unstructured":"Givens JR, Andersen RN, Wiser WL, Fish AS. Dynamics of suppression and recovery of plasma FSH, LH, androstenedione and testosterone in polycystic ovarian disease using an oral contraceptive. J Clin Endocrinol Metab 1974;38:717-35.","journal-title":"German Med Monthly"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1210\/jcem-39-1-81","article-title":"The evaluation of the role of androgens in hirsutism and the use of a new anti-androgen \"cyproterone acetate\"","volume":"39","author":"Ismail, A.A.A.; Davidson, D.W.; Souka, A.R.","year":"1974","unstructured":"Hammerstein J, Cupceancu B. The treatment of hirsutism with cyproterone acetate. German Med Monthly 1969;14:599-602.","journal-title":"for therapy. J Clin Endocrinol Metab"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1111\/j.1365-2265.1975.tb03305.x","article-title":"Cyproterone acetate: a study involving two volunteers with idiopathic hirsutism","volume":"4","author":"Barnes, E.W.; Irvine, W.J.; Hunter, W.M.; Ismail, A.A.A.","year":"1975","unstructured":"Ismail AAA, Davidson DW, Souka AR. The evaluation of the role of androgens in hirsutism and the use of a new anti-androgen \"cyproterone acetate\" for therapy. J Clin Endocrinol Metab 1974;39:81-95.","journal-title":"Clin Endocrinol"},{"key":"ref_26","first-page":"1140","article-title":"Cyproterone acetate","volume":"ii:","author":"Jeffcoate, W.J.; Edwards, C.R.W.; Rees, L.H.; Besser, G.M.","year":"1976","unstructured":"Barnes EW, Irvine WJ, Hunter WM, Ismail AAA. Cyproterone acetate: a study involving two volunteers with idiopathic hirsutism. Clin Endocrinol 1975;4:65-73.","journal-title":"Lancet"},{"key":"ref_27","article-title":"The pharmacology and uses of androcur","year":"1974","unstructured":"Jeffcoate WJ, Edwards CRW, Rees LH, Besser GM. Cyproterone acetate. Lancet 1976;ii:1140.","journal-title":"Schering"},{"article-title":"Accepted","year":"1979","key":"ref_28","unstructured":"The pharmacology and uses of androcur. Schering, 1974;17."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000180436","volume":"14","author":"Emmerson, B.; Ravenscroft, P.","year":"1975","unstructured":"(Accepted 19 October 1979)","journal-title":"Nephron"},{"key":"ref_30","article-title":"The leading article on surgical diathermy","volume-title":"reminds us of the possible dangers associated with its use. Is the following another possible hazard ? I suspect that in coagulating the blood flowing through the vessels a clot forms on the surface end which might also extend inwards and become detached to enter the systemic circulation. Such clots ifformed in large quantities might cause post-traumatic respiratory insufficiency, especially after surgery necessitating large wounds","year":"1979","unstructured":"Emmerson B, Ravenscroft P. Nephron 1975;14:62."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6211.369","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6211.369","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T18:59:01Z","timestamp":1765393141000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6211.369"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,2,9]]},"references-count":30,"journal-issue":{"issue":"6211","published-online":{"date-parts":[[1980,2,9]]},"published-print":{"date-parts":[[1980,2,9]]}},"alternative-id":["10.1136\/bmj.280.6211.369"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6211.369","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,2,9]]}}}