{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T17:49:07Z","timestamp":1773078547145,"version":"3.50.1"},"reference-count":13,"publisher":"BMJ","issue":"6215","license":[{"start":{"date-parts":[[1980,3,8]],"date-time":"1980-03-08T00:00:00Z","timestamp":321321600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,3,8]]},"abstract":"<jats:p>Plasma concentrations and total amounts of pregnancy associated plasma protein A were determined in 272 patients at 34 weeks' gestation by immunoelectrophoretic assay. The mean plasma concentration and mean total amount of this protein were closely related (r = 0.9643) and were significantly raised in patients who subsequently developed pre-eclampsia (28 patients), went into premature labour (12), or suffered from antepartum haemorrhage (10). Mean values in all patients delivering growth-retarded babies were also raised, but when the results for such patients who also had other complications were excluded there were no differences between the sets of means. The assays were easily performed, and they may be a useful technique for screening pregnant women to detect those at risk of developing pre-eclamptic toxaemia, although the full potential of these assays cannot be realised until the protein's function is known.<\/jats:p>","DOI":"10.1136\/bmj.280.6215.671","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"671-673","source":"Crossref","is-referenced-by-count":40,"title":["Assay of a placental protein to determine fetal risk."],"prefix":"10.1136","volume":"280","author":[{"given":"G","family":"Hughes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Bischof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Klopper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,3,8]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0002-9378(74)90553-5","article-title":"Characterization of four human pregnancy-associated plasma proteins","volume":"118","author":"Lin, T.M.; Halbert, S.P.; Kiefer, D.; Spellacy, W.; Gall, S.","year":"1974","unstructured":"Lin TM, Halbert SP, Kiefer D, Spellacy W, Gall S. 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Clin Chim Acta 1979;95:243-7.","journal-title":"Clin Chim Acta"},{"key":"ref_6","first-page":"105","article-title":"Observations on the isolation of pregnancy-associated plasma protein","author":"Bischof, P.","year":"1979","unstructured":"Bischof P. Observations on the isolation of pregnancy-associated plasma protein A. In: Klopper A, Chard T, eds. Placental proteins. Heidelberg: Springer-Verlag, 1979:105-18."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/j.1471-0528.1968.tb01615.x","article-title":"The assessment of fetal growth","volume":"75","author":"Thomson, A.M.; Billewicz, W.Z.; Hytten, F.E.","year":"1968","unstructured":"Thomson AM, Billewicz WZ, Hytten FE. The assessment of fetal growth. Journal of Obstetrics and Gynaecology of the British Commonwealth 1968;75:903-12.","journal-title":"Journal of Obstetrics and Gynaecology of the British Commonwealth"},{"key":"ref_8","first-page":"1","article-title":"Normality and abnormality","volume-title":"Plasma hormone assays in evaluation offetal wellbeing","author":"Chard, T.","year":"1976","unstructured":"Chard T. Normality and abnormality. In: Klopper A, ed. Plasma hormone assays in evaluation offetal wellbeing. Edinburgh: Churchill Livingstone, 1976:1-19."},{"key":"ref_9","first-page":"23","article-title":"The measurement of trophoblastic proteins as a test of placental function","author":"Klopper, A.; Smith, R.; Davidson, I.","year":"1979","unstructured":"Klopper A, Smith R, Davidson I. The measurement of trophoblastic proteins as a test of placental function. In: Klopper A, Chard T, eds. Placental proteins. Heidelberg: Springer-Verlag, 1979:23-42."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1016\/0002-9378(77)90725-6","article-title":"Plasma concentrations of four pregnancy proteins in complications of pregnancy","volume":"128","author":"Lin, T.M.; Halbert, S.P.; Spellacy, W.N.; Berne, B.H.","year":"1977","unstructured":"Lin TM, Halbert SP, Spellacy WN, Berne BH. Plasma concentrations of four pregnancy proteins in complications of pregnancy. Am J Obstet Gynecol 1977;128:808-10.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0143-4004(80)80017-8","article-title":"The new placental proteins","volume":"1","author":"Klopper, A.","year":"1980","unstructured":"Klopper A. The new placental proteins. Placenta 1980;1:77-89.","journal-title":"Placenta"},{"key":"ref_12","article-title":"Accepted 17","year":"1979","unstructured":"(Accepted 17 December 1979)"},{"key":"ref_13","article-title":"These results suggest an association between increased blood viscosity and extensive coronary artery disease in men, which merits further investigation","unstructured":"These results suggest an association between increased blood viscosity and extensive coronary artery disease in men, which merits further investigation."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6215.671","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6215.671","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:30:37Z","timestamp":1765395037000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6215.671"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,8]]},"references-count":13,"journal-issue":{"issue":"6215","published-online":{"date-parts":[[1980,3,8]]},"published-print":{"date-parts":[[1980,3,8]]}},"alternative-id":["10.1136\/bmj.280.6215.671"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6215.671","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3,8]]}}}