{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:41:15Z","timestamp":1765395675194,"version":"3.46.0"},"reference-count":15,"publisher":"BMJ","issue":"6216","license":[{"start":{"date-parts":[[1980,3,15]],"date-time":"1980-03-15T00:00:00Z","timestamp":321926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,3,15]]},"abstract":"<jats:p>Vagal function in 28 patients with gastro-oesophageal reflux was examined by determining gastric secretory response to insulin-induced hypoglycaemia and pulse-rate variation with respiration. Gastric secretory studies were also performed on 13 patients with duodenal ulcer who had not undergone operations. In all patients the presence and degree of oesophagitis were determined endoscopically and mucosal biopsy and oesophageal manometry were performed. Seven of the 28 patients with gastro-oesophageal reflux showed evidence of impaired vagal efferent function in the upper alimentary tract. No such impairment was found in those patients who showed manometric evidence of oesophageal spasm secondary to gastro-oesophageal reflux. Low pulse-rate variation with respiration was found in 12 of 27 patients with gastro-oesophageal reflux, suggesting dysfunction of cardiac vagal fibres. Impairment of efferent vagal supply may be a causative factor in some patients with gastr-oesophageal reflux but does not seem to be important in oesophageal spasm secondary to gastro-oesophageal reflux.<\/jats:p>","DOI":"10.1136\/bmj.280.6216.755","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"755-757","source":"Crossref","is-referenced-by-count":26,"title":["Vagal function in relation to gastro-oesophageal reflux and associated motility changes."],"prefix":"10.1136","volume":"280","author":[{"given":"R V","family":"Heatley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Collins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Atkinson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,3,15]]},"reference":[{"key":"ref_1","first-page":"32","article-title":"Responses of the gastro-oesophageal junction to increase in intra-abdominal pressure","volume":"9","author":"Lind, J.F.; Warrian, W.C.; Wankling, W.J.","year":"1966","unstructured":"Lind JF, Warrian WC, Wankling WJ. Responses of the gastro-oesophageal junction to increase in intra-abdominal pressure. Can Y Surg 1966;9: 32-8.","journal-title":"Can Y Surg"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1002\/bjs.1800640704","article-title":"The effect of vagotomy on the lower oesophageal sphincter-a manometric study","volume":"64","author":"Angorn, I.B.; Dimopoulos, G.; Hegarty, M.M.; Moshal, M.G.","year":"1977","unstructured":"Angorn IB, Dimopoulos G, Hegarty MM, Moshal MG. The effect of vagotomy on the lower oesophageal sphincter-a manometric study. Br Jf Surg 1977;64:466-9.","journal-title":"Br Jf Surg"},{"key":"ref_3","article-title":"After vagotomy","author":"Alexander-Williams, J.; Cox, A.J.","year":"1969","unstructured":"Alexander-Williams J, Cox AJ. After vagotomy. London: Butterworth, 1969."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1002\/bjs.1800641203","article-title":"Abnormalities of gastric emptying and pyloric reflux in uncomplicated hiatus hernia","volume":"64","author":"Donovan, I.A.; Harding, L.K.; Keighley, M.R.B.; Griffin, D.W.; Collis, J.L.","year":"1977","unstructured":"Donovan IA, Harding LK, Keighley MRB, Griffin DW, Collis JL. Abnormalities of gastric emptying and pyloric reflux in uncomplicated hiatus hernia. BrJ Surg 1977;64:847-8.","journal-title":"BrJ Surg"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1136\/thx.31.3.278","article-title":"Oesophageal motor changes in diabetes mellitus","volume":"31","author":"Stewart, I.M.; Hosking, D.J.; Preston, B.J.; Atkinson, M.","year":"1976","unstructured":"Stewart IM, Hosking DJ, Preston BJ, Atkinson M. Oesophageal motor changes in diabetes mellitus. Thorax 1976;31:278-83.","journal-title":"Thorax"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0016-5085(75)80079-5","article-title":"A rapid pull-through technique for measuring lower oesophageal sphincter pressure","volume":"68","author":"Dodds, W.J.; Hogan, W.J.; Stef, J.J.; Miller, W.N.; Lyndon, S.B.; Arndorfer, R.C.","year":"1975","unstructured":"Dodds WJ, Hogan WJ, Stef JJ, Miller WN, Lyndon SB, Arndorfer RC. A rapid pull-through technique for measuring lower oesophageal sphincter pressure. Gastroenterology 1975;68:437-43.","journal-title":"Gastroenterology"},{"key":"ref_7","first-page":"588","article-title":"Vagal impairment of gastric secretion in diabetic autonomic neuropathy. Br Med J'","volume":"ii:","author":"Hosking, D.J.; Moody, F.; Stewart, I.M.; Atkinson, M.","year":"1975","unstructured":"Hosking DJ, Moody F, Stewart IM, Atkinson M. Vagal impairment of gastric secretion in diabetic autonomic neuropathy. Br Med J' 1975; ii:588-91."},{"key":"ref_8","first-page":"757","article-title":"The value of a combined pentagastrin\/insulin test in studies of stomal ulceration","volume-title":"BrJ3 Surg","volume":"57","author":"Venables, C.W.","year":"1970","unstructured":"Venables CW. The value of a combined pentagastrin\/insulin test in studies of stomal ulceration. BrJ3 Surg 1970;57:757-61."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"885","DOI":"10.3109\/00365527809182208","article-title":"Gastro-esophageal sphincter pressure and serum gastrin studies following food intake before and after vagotomy for duodenal ulcer","volume":"13","year":"1978","unstructured":"Csendes A, Oster M, Brandsborg 0, Moeller J, Brandsborg M, Amdrup E. Gastro-esophageal sphincter pressure and serum gastrin studies following food intake before and after vagotomy for duodenal ulcer. Scand J Gastroenterol 1978;13:885-9.","journal-title":"Scand J Gastroenterol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/S0039-6109(16)38383-9","article-title":"The effect of sub-diaphragmatic vagotomy on the function of the gastro-oesophageal sphincter","volume":"47","author":"Alexander-Williams, J.; Woodward, D.A.K.","year":"1967","unstructured":"Alexander-Williams J, Woodward DAK. The effect of sub-diaphragmatic vagotomy on the function of the gastro-oesophageal sphincter. Surg Clin North Am 1967;47:1341-4.","journal-title":"Surg Clin North Am"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1136\/gut.9.6.688","article-title":"The effect of vagotomy on the human gastrooesophageal sphincter","volume":"9","author":"Mann, C.V.; Hardcastle, J.D.","year":"1968","unstructured":"Mann CV, Hardcastle JD. The effect of vagotomy on the human gastrooesophageal sphincter. Gut 1968;9:688-95.","journal-title":"Gut"},{"key":"ref_12","first-page":"205","article-title":"Gastric emptying in patients with reflux esophagitis or benign strictures of the esophagus secondary to reflux compared to controls","volume":"13","author":"Csendes, A.; Henriquez, A.","year":"1978","unstructured":"Csendes A, Henriquez A. Gastric emptying in patients with reflux esophagitis or benign strictures of the esophagus secondary to reflux compared to controls. ScandJ3 Gastroenterol 1978;13:205-7."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1001\/jama.1965.03080050025006","article-title":"Diffuse spasm of the lower part of the oesophagus-fine structure of esophageal smooth muscle and nerve","volume":"191","author":"Casella, R.R.; Ellis, F.H.; Brown, A.L.","year":"1965","unstructured":"Casella RR, Ellis FH, Brown AL. Diffuse spasm of the lower part of the oesophagus-fine structure of esophageal smooth muscle and nerve. JAMA 1965;191:379-82.","journal-title":"JAMA"},{"article-title":"Accepted 17","year":"1979","key":"ref_14","unstructured":"(Accepted 17 December 1979)"},{"key":"ref_15","article-title":"The Court for Crown Cases Reserved held that it was a question for the jury; that is to say, whether Miss B was a lunatic or not, whatever might be thought by the prisoner or by the Commissioners who had seen her; and therefore the conviction has been affirmed. It would be interesting to know the amount of the little bill which the public will have to pay for this prosecution of a poor woman who did not know that she was doing wrong, and whose ignorance was shared by some of her prosecutors","volume":"1880","unstructured":"The Court for Crown Cases Reserved held that it was a question for the jury; that is to say, whether Miss B was a lunatic or not, whatever might be thought by the prisoner or by the Commissioners who had seen her; and therefore the conviction has been affirmed. It would be interesting to know the amount of the little bill which the public will have to pay for this prosecution of a poor woman who did not know that she was doing wrong, and whose ignorance was shared by some of her prosecutors. (British Medical Journal, 1880.)","journal-title":"(British Medical Journal"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6216.755","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6216.755","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:36:36Z","timestamp":1765395396000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6216.755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,15]]},"references-count":15,"journal-issue":{"issue":"6216","published-online":{"date-parts":[[1980,3,15]]},"published-print":{"date-parts":[[1980,3,15]]}},"alternative-id":["10.1136\/bmj.280.6216.755"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6216.755","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,3,15]]}}}