{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:41:16Z","timestamp":1765395676030,"version":"3.46.0"},"reference-count":16,"publisher":"BMJ","issue":"6216","license":[{"start":{"date-parts":[[1980,3,15]],"date-time":"1980-03-15T00:00:00Z","timestamp":321926400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,3,15]]},"abstract":"<jats:p>Immunoreactive methionine enkephalin and beta-endorphin were sought by serial dilution of tissue extracts and assay of chromatographic fractions in non-endocrine tumour tissue from three patients with the ectopic adrenocorticotrophin syndrome associated with carcinoid tumours and in normal lung tissue and thymic tissue from a patient with myasthenia gravis. In all cases serial dilution of extracts showed parellelism to standard radioimmunoassay curves. The two peptides were found in high concentration in the three tumours but were undetectable in the control tissues. In a single case tested the methionine enkephalin concentration in a vein draining the tumour was twice that in a peripheral vein. In view of their profound effect on behaviour in animals and potent analgesic activity in animals and man the ectopic secretion of methionine enkephalin and beta-endorphin may modify the clinical features of a wide variety of tumours and produce some of the diverse clinical syndromes associated with malignancy.<\/jats:p>","DOI":"10.1136\/bmj.280.6216.758","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"758-759","source":"Crossref","is-referenced-by-count":43,"title":["Ectopic production of methionine enkephalin and beta-endorphin."],"prefix":"10.1136","volume":"280","author":[{"given":"P T","family":"Pullan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Clement-Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"Corder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L H","family":"Rees","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Besser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Galvao-Teles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,3,15]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/bmj.1.6067.996","article-title":"Plasma immunoreactive corticotrophin and lipotrophin in Cushing's syndrome and Addison's desease","volume":"i:","author":"Gilkes, J.J.H.; Rees, L.H.; Besser, G.M.","year":"1977","unstructured":"Gilkes JJH, Rees LH, Besser GM. Plasma immunoreactive corticotrophin and lipotrophin in Cushing's syndrome and Addison's desease. Br Med J 1977;i:996-8.","journal-title":"Br Med J"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"3014","DOI":"10.1073\/pnas.74.7.3014","article-title":"Common precursor to corticotrophins and endorphins","volume":"74","author":"Mains, R.E.; Eipper, B.A.; Ling, N.R.","year":"1977","unstructured":"Mains RE, Eipper BA, Ling NR. Common precursor to corticotrophins and endorphins. Proc Natl Acad Sci USA 1977;74:3014-8.","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1126\/science.959823","article-title":"Opioid peptides in pituitary and brain","volume":"193","author":"Goldstein, A.","year":"1976","unstructured":"Goldstein A. Opioid peptides in pituitary and brain. Science 1976;193: 1081-6.","journal-title":"Science"},{"issue":"2","key":"ref_4","first-page":"1","article-title":"P-Endorphin in human cerebrospinal fluid","volume":"119","author":"Jeffcoate, W.J.; McLoughlin, L.; Rees, L.H.","year":"1978","unstructured":"Jeffcoate WJ, McLoughlin L, Rees LH, et al. P-Endorphin in human cerebrospinal fluid. Lancet 1978;ii: 119-2 1.","journal-title":"Lancet"},{"key":"ref_5","first-page":"849","article-title":"Development of a specific extracted radioimmunoassay for methionine enkephalin in human plasma and cerebrospinal fluid","volume":"46","author":"Clement-Jones, V.; Lowry, P.J.; Rees, L.H.; Besser, G.M.","year":"1978","unstructured":"Clement-Jones V, Lowry PJ, Rees LH, Besser GM. Development of a specific extracted radioimmunoassay for methionine enkephalin in human plasma and cerebrospinal fluid.J Endocrinol (in press). 6McLoughlin L, Lowry PJ, Ratter SJ, Besser GM, Rees LH.,-Endorphin and 3-MSH in human plasma. Clin Endocrinol (Oxf) (in press). I Orth DN, Guillemin R, Ling N, Nicholson WE. Immunoreactive endorphins, lipotrophins and corticotrophins in a human non-pituitary tumor: evidence for a common precursor. J Clin Endocrinol Metab 1978;46: 849-52.","journal-title":"J Endocrinol; Rees LH.,-Endorphin and 3-MSH in human plasma. Clin Endocrinol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0140-6736(78)90271-4","article-title":"Enkephalin in peripheral neuroendocrine tumours","volume":"i:","author":"Sullivan, S.N.; Bloom, SR, Polak; J.M.","year":"1978","unstructured":"Sullivan SN, Bloom SR, Polak JM. Enkephalin in peripheral neuroendocrine tumours. Lancet 1978;i:986-7.","journal-title":"Lancet"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/283295a0","article-title":"Metenkephalin circulates in human plasma","volume":"283","author":"Clement-Jones, V.; Lowry, P.J.; Rees, L.H.; Besser, G.M.","year":"1980","unstructured":"Clement-Jones V, Lowry PJ, Rees LH, Besser GM. Metenkephalin circulates in human plasma. Nature 1980;283:295-7.","journal-title":"Nature"},{"key":"ref_8","first-page":"630","article-title":"Endorphins: profound behavioural effects in rats suggest new aetiological factors in mental illness","author":"Bloom, F.; Segal, D.; Ling, N.; Guillemin, R.","year":"1976","unstructured":"Bloom F, Segal D, Ling N, Guillemin R. Endorphins: profound behavioural effects in rats suggest new aetiological factors in mental illness. Science 1976;194:630-2.","journal-title":"Science"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1126\/science.185695","article-title":"The C-fragment of f-lipotrophin: an endogenous neuroleptic or antipsychotogen ?","author":"Jacquet, Y.F.; Marks, N.","year":"1976","unstructured":"Jacquet YF, Marks N. The C-fragment of f-lipotrophin: an endogenous neuroleptic or antipsychotogen ? Science 1976;194:632-5.","journal-title":"Science"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1176\/ajp.123.12.1553","article-title":"Comparison of psychiatric symptoms in carcinoma of the pancreas with those in some other intra-abdominal neoplasms","volume":"123","author":"Fras, I.; Litin, E.M.; Pearson, J.S.","year":"1967","unstructured":"Fras I, Litin EM, Pearson JS. Comparison of psychiatric symptoms in carcinoma of the pancreas with those in some other intra-abdominal neoplasms. Amy Psychiatry 1967;123:1553-62.","journal-title":"Amy Psychiatry"},{"issue":"115","key":"ref_11","first-page":"1277","article-title":"The relationship between premature death and affective disorders","volume":"1969","author":"Kerr, T.A.; Schapira, K.; Roth, M.","unstructured":"Kerr TA, Schapira K, Roth M. The relationship between premature death and affective disorders. BrJ Psychiatry 1969;115:1277-82.","journal-title":"BrJ Psychiatry"},{"key":"ref_12","first-page":"2895","article-title":"3-Endorphin is a","volume-title":"potent analgesic agent. Proc NatlAcad Sci USA","volume":"73","author":"Loh, H.H.; Tseng, L.F.; Wei, E.; Li, C.H.","year":"1976","unstructured":"Loh HH, Tseng LF, Wei E, Li CH. 3-Endorphin is a potent analgesic agent. Proc NatlAcad Sci USA 1976;73:2895-8."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/260625a0","article-title":"Analgesia induced in vivo by central administration of enkephalin in the rat","volume":"260","author":"Belluzi, J.D.; Grant, N.; Garsky, V.; Sarantakis, D.; Wise, C.D.; Stein, L.","year":"1976","unstructured":"Belluzi JD, Grant N, Garsky V, Sarantakis D, Wise CD, Stein L. Analgesia induced in vivo by central administration of enkephalin in the rat. Nature 1976;260:625-6.","journal-title":"Nature"},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1365-2265.1977.tb02000.x","article-title":"Lung tumours and ACTH production","volume":"6","author":"Bloomfield, G.A.; Holdaway, I.M.; Corrin, B.","year":"1977","unstructured":"Bloomfield GA, Holdaway IM, Corrin B, et al. Lung tumours and ACTH production. Clin Endocrinol (Oxf) 1977;6:95-104.","journal-title":"Clin Endocrinol (Oxf)"},{"article-title":"Accepted 2","year":"1980","key":"ref_15","unstructured":"(Accepted 2 January 1980)"},{"key":"ref_16","article-title":"ONE HUNDRED YEARS AGO At an asylum in Vienna (says the Danube), a novel method of treatment has been adopted. The director has established a lithographed joumal for circulation in the asylum, and he induces the patients to contribute to it. Especially he encourages them to refute the manias of their comrades. The man who believes his nose to be made of sugar-candy, and liable to dissolve, he says, can argue with excellent logic against the folly of his friend's theory that his beard is a tender plant and needs frequent watering. As a rule, they are able to discuss with good sense all subjects except those which concern their peculiar delusion","volume":"1880","unstructured":"ONE HUNDRED YEARS AGO At an asylum in Vienna (says the Danube), a novel method of treatment has been adopted. The director has established a lithographed joumal for circulation in the asylum, and he induces the patients to contribute to it. Especially he encourages them to refute the manias of their comrades. The man who believes his nose to be made of sugar-candy, and liable to dissolve, he says, can argue with excellent logic against the folly of his friend's theory that his beard is a tender plant and needs frequent watering. As a rule, they are able to discuss with good sense all subjects except those which concern their peculiar delusion. (British Medical Journal, 1880.)","journal-title":"(British Medical Journal"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6216.758","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6216.758","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:36:42Z","timestamp":1765395402000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6216.758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,15]]},"references-count":16,"journal-issue":{"issue":"6216","published-online":{"date-parts":[[1980,3,15]]},"published-print":{"date-parts":[[1980,3,15]]}},"alternative-id":["10.1136\/bmj.280.6216.758"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6216.758","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,3,15]]}}}