{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T20:30:17Z","timestamp":1768249817903,"version":"3.49.0"},"reference-count":13,"publisher":"BMJ","issue":"6218","license":[{"start":{"date-parts":[[1980,3,29]],"date-time":"1980-03-29T00:00:00Z","timestamp":323136000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,3,29]]},"abstract":"<jats:p>Day time somnolence or excessive snoring, or both, occurred in five out of 11 patients with acromegaly. All five had episodes of sleep apnoea, and three had the sleep apnoea syndrome. Growth hormone concentrations were higher (p less than 0.025) in these patients than in the six patients without these symptoms. One patient with daytime somnolence and one asymptomatic patient had flow loop evidence of upper airways obstruction. Two of the patients with the sleep apnoea syndrome had cardiomegaly. Sleep apnoea appears to be common and clinically important in acromegaly, and it may be central, obstructive, or mixed. Polygraphic nocturnal monitoring is indicated to assess these patients properly.<\/jats:p>","DOI":"10.1136\/bmj.280.6218.894","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"894-897","source":"Crossref","is-referenced-by-count":89,"title":["Sleep apnoea in acromegaly."],"prefix":"10.1136","volume":"280","author":[{"given":"W H","family":"Perks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Horrocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Bradbury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N","family":"Baldock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Prowse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"van't Hoff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,3,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1136\/thx.32.3.322","article-title":"Pulmonary function in acromegaly","volume":"32","author":"l Evans CC, Hipkin LJ, Murray GM","year":"1977","unstructured":"l Evans CC, Hipkin LJ, Murray GM. Pulmonary function in acromegaly. Thorax 1977;32:322-7.","journal-title":"Thorax"},{"key":"ref_2","first-page":"909","article-title":"Control of breathing during sleep","volume":"118","author":"Phillipson, E.A.","year":"1978","unstructured":"Phillipson EA. Control of breathing during sleep. Am Rev Resp Dis 1978;118:909-39.","journal-title":"Am Rev Resp Dis"},{"key":"ref_3","first-page":"1","article-title":"Clinical review of the sleep apnea syndromes","volume-title":"apnea syndromes","author":"Guilleminault, C.; Van den Hoed, J.; Mitler, M.M.","year":"1978","unstructured":"Guilleminault C, Van den Hoed J, Mitler MM. Clinical review of the sleep apnea syndromes. In: Guilleminault C, Dement WC, eds. Sleep apnea syndromes. New York: Academic Press, 1978:1-12."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/S0140-6736(79)90684-6","article-title":"Acromegaly and narcolepsy","volume":"ii:","author":"Guilleminault, C.; Van den Hoed, J.","year":"1979","unstructured":"Guilleminault C, Van den Hoed J. Acromegaly and narcolepsy. Lancet 1979;ii:750-1.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0140-6736(79)90346-5","article-title":"Acromegaly and narcolepsy","volume":"ii:","author":"Barnes, A.J.; Pallis, C.; Joplin, G.F.","year":"1979","unstructured":"Barnes AJ, Pallis C, Joplin GF. Acromegaly and narcolepsy. Lancet 1979,ii:332-3.","journal-title":"Lancet"},{"key":"ref_6","article-title":"Manual of standardized terminology, techniques and scoring system for sleep stages of human subjects","author":"Rechtshaffen, A.; Kales, A.","year":"1968","unstructured":"Rechtshaffen A, Kales A. Manual of standardized terminology, techniques and scoring system for sleep stages of human subjects. Bethesda, Maryland: National Institute of Neurological Disease and Blindness, 1968."},{"key":"ref_7","article-title":"Non-parametric statistics for the behavioral sciences","author":"Seigel, S.","year":"1956","unstructured":"Seigel S. Non-parametric statistics for the behavioral sciences. New York: McGraw-Hill, 1956."},{"key":"ref_8","article-title":"Cardiac arrhythmias in sleep apnea","volume-title":"apnea syndromes","author":"Tilkian, A.G.; Motta, J.; Guilleminault, C.","year":"1978","unstructured":"Tilkian AG, Motta J, Guilleminault C. Cardiac arrhythmias in sleep apnea. In: Guilleminault C, Dement WC, eds. Sleep apnea syndromes. New York: Academic Press, 1978:197-210."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/S0140-6736(79)91576-9","article-title":"Acromegaly and narcolepsy","volume":"ii:","author":"Rees, P.J.; Ayres, J.G.","year":"1979","unstructured":"Rees PJ, Ayres JG. Acromegaly and narcolepsy. Lancet 1979;ii:524-5.","journal-title":"Lancet"},{"key":"ref_10","article-title":"Lung function: assessment and application in medicine","author":"Cotes, J.E.","year":"1975","unstructured":"Cotes JE. Lung function: assessment and application in medicine. Oxford: Blackwell Scientific Publications, 1975."},{"key":"ref_11","article-title":"Accepted 28","year":"1980","unstructured":"(Accepted 28 January 1980)"},{"key":"ref_12","article-title":"Information about 150 children aged under 12 months who were admitted to hospital while acutely ill and survived was obtained from studies in Sheffield and Gateshead between November 1977 and April 1978. Seventy-two children were from Sheffield and 78 from Gateshead. The Gateshead series comprised consecutive admissions to the Queen Elizabeth Hospital, the only hospital within the area health authority admitting paediatric emergencies. Only one family refused to be interviewed. The Sheffield series was compiled by weekly rotation of interviews between the three hospitals in the city that accepted acute admissions","unstructured":"Information about 150 children aged under 12 months who were admitted to hospital while acutely ill and survived was obtained from studies in Sheffield and Gateshead between November 1977 and April 1978. Seventy-two children were from Sheffield and 78 from Gateshead. The Gateshead series comprised consecutive admissions to the Queen Elizabeth Hospital, the only hospital within the area health authority admitting paediatric emergencies. Only one family refused to be interviewed. The Sheffield series was compiled by weekly rotation of interviews between the three hospitals in the city that accepted acute admissions."},{"key":"ref_13","article-title":"During 1977, 228 general practitioners covered the city of Sheffield, which had a mid-year population of 547 400 and in which 5457 births occurred. Ninety-nine general practitioners covered Gateshead, which had a mid-year population of 217 500 and 3264 births","unstructured":"During 1977, 228 general practitioners covered the city of Sheffield, which had a mid-year population of 547 400 and in which 5457 births occurred. Ninety-nine general practitioners covered Gateshead, which had a mid-year population of 217 500 and 3264 births."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6218.894","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6218.894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:50:54Z","timestamp":1765396254000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6218.894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,3,29]]},"references-count":13,"journal-issue":{"issue":"6218","published-online":{"date-parts":[[1980,3,29]]},"published-print":{"date-parts":[[1980,3,29]]}},"alternative-id":["10.1136\/bmj.280.6218.894"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6218.894","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,3,29]]}}}