{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:58:39Z","timestamp":1781319519283,"version":"3.54.1"},"reference-count":20,"publisher":"BMJ","issue":"6219","license":[{"start":{"date-parts":[[1980,4,5]],"date-time":"1980-04-05T00:00:00Z","timestamp":323740800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,4,5]]},"abstract":"<jats:p>The haemodynamic effects of intravenous morphine sulphate (0.2 mg\/kg body weight) were measured in 10 patients with acute myocardial infarction complicated by severe left ventricular failure. Fifteen minutes after morphine injection there was a significant fall in mean heart rate (from 109 to 101 beats\/min) and mean systemic arterial pressure (from 80 to 65 mm HG), and a small fall in mean cardiac index (from 2.4 to 2.21\/min\/m2). Haemodynamic changes at 45 minutes were similar. Neither stroke index nor indirect left ventricular filling pressure (measured as pulmonary artery end-diastolic pressure) were consistently improved 15 or 45 minutes after injection. The useful action of morphine in relieving distressing cardiac dyspnoea is not adequately explained by systemic venous blood pooling. These results suggest that the effects of morphine on the central nervous system are more important.<\/jats:p>","DOI":"10.1136\/bmj.280.6219.980","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"980-982","source":"Crossref","is-referenced-by-count":31,"title":["Haemodynamic effects of intravenous morphine in patients with acute myocardial infarction complicated by severe left ventricular failure."],"prefix":"10.1136","volume":"280","author":[{"given":"A D","family":"Timmis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M T","family":"Rothman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M A","family":"Henderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P W","family":"Geal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D A","family":"Chamberlain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,4,5]]},"reference":[{"key":"ref_1","first-page":"863","volume":"27","author":"HeartJ7, Br","year":"1965","unstructured":"Br HeartJ7 1965;27:863-75."},{"key":"ref_2","first-page":"379","article-title":"Cardiovascular and respiratory effects of morphine and pentazocine in patients with myocardial infarction","volume":"i:","author":"Lal, S.; Savidge, R.S.; Chhabra, G.P.","year":"1969","unstructured":"Lal S, Savidge RS, Chhabra GP. Cardiovascular and respiratory effects of morphine and pentazocine in patients with myocardial infarction. Lancet 1969;i:379-81.","journal-title":"Lancet"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0140-6736(69)91704-8","article-title":"Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction","volume":"i:","author":"Scott, M.E.; Orr, R.","year":"1969","unstructured":"Scott ME, Orr R. Effects of diamorphine, methadone, morphine, and pentazocine in patients with suspected acute myocardial infarction. 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The effects of morphine on the resistance and capacitance vessels of the peripheral circulation. Am HeartJ 1966;72:242-50.","journal-title":"Am HeartJ"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/0002-9149(66)90433-4","article-title":"Mechanisms of action of morphine in the treatment of experimental pulmonary edema","volume":"18","author":"Vasko, J.S.; Henney, R.P.; Oldham, H.N.; Brawley, R.K.; Morrow, A.G.","year":"1966","unstructured":"Vasko JS, Henney RP, Oldham HN, Brawley RK, Morrow AG. Mechanisms of action of morphine in the treatment of experimental pulmonary edema. Am J Cardiol 1966;18:876-83.","journal-title":"Am J Cardiol"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/0002-9149(72)90167-1","article-title":"Effects of morphine on the peripheral vascular response to sympathetic stimulation","volume":"29","author":"Ward, J.M.; McGrath, R.L.; Weil, J.V.","year":"1972","unstructured":"Ward JM, McGrath RL, Weil JV. Effects of morphine on the peripheral vascular response to sympathetic stimulation. Am Jf Cardiol 1972; 29:659-66.","journal-title":"Am Jf Cardiol"},{"key":"ref_8","first-page":"1247","article-title":"The cardiovascular effects of morphine","volume-title":"The peripheral capacitance and resistance vessels in human subjects. Jf Clin Invest","volume":"54","author":"Zelis, R.; Mansour, E.J.; Capone, R.J.; Mason, D.T.","year":"1974","unstructured":"Zelis R, Mansour EJ, Capone RJ, Mason DT. The cardiovascular effects of morphine. The peripheral capacitance and resistance vessels in human subjects. Jf Clin Invest 1974;54:1247-58."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1161\/01.CIR.54.2.335","article-title":"The effects of morphine on venous tone in patients with acute pulmonary edema","volume":"54","author":"Vismara, L.A.; Leaman, D.M.; Zelis, R.","year":"1976","unstructured":"Vismara LA, Leaman DM, Zelis R. The effects of morphine on venous tone in patients with acute pulmonary edema. Circulation 1976;54:335-7.","journal-title":"Circulation"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1136\/hrt.40.5.569","article-title":"Effect of morphine on splanchnic blood flow","volume":"40","author":"Leaman, D.M.; Levenson, L.; Zelis, R.; Shiroff, R.","year":"1978","unstructured":"Leaman DM, Levenson L, Zelis R, Shiroff R. Effect of morphine on splanchnic blood flow. Br HeartJ 1978;40:569-71.","journal-title":"Br HeartJ"},{"key":"ref_11","first-page":"249","article-title":"A sensitive fluorimetric assay","volume-title":"for morphine. Fed Proc 1963","volume":"22","author":"Kupferberg, H.J.; Burkhalter, A.; Way, E.L.","unstructured":"Kupferberg HJ, Burkhalter A, Way EL. A sensitive fluorimetric assay for morphine. Fed Proc 1963;22:249-55."},{"issue":"107","key":"ref_12","first-page":"450","article-title":"The lung in congestive heart failure","volume":"1961","author":"Ebert, R.V.","unstructured":"Ebert RV. The lung in congestive heart failure. Arch Intern Med 1961; 107:450-9.","journal-title":"Arch Intern Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1097\/00000542-197502000-00007","article-title":"Filling pressures of the heart and pulmonary circulation of the patient with coronary artery disease after large intravenous doses of morphine","volume":"42","author":"Lappas, D.G.; Geha, D.; Fischer, J.E.; Laver, M.B.; Lowenstein, E.","year":"1975","unstructured":"Lappas DG, Geha D, Fischer JE, Laver MB, Lowenstein E. Filling pressures of the heart and pulmonary circulation of the patient with coronary artery disease after large intravenous doses of morphine. Anesthesiology 1975;42:153-9.","journal-title":"Anesthesiology"},{"key":"ref_14","first-page":"47","article-title":"Hemodynamic effects of morphine during and early after cardiac operations","volume":"55","author":"Moffitt, E.A.; Tarhan, S.; Rudriguez, R.; Barnhorst, D.A.; Pluth, JR","year":"1976","unstructured":"Moffitt EA, Tarhan S, Rudriguez R, Barnhorst DA, Pluth JR. Hemodynamic effects of morphine during and early after cardiac operations. Anesth Analg (Cleve) 1976;55:47-50.","journal-title":"Anesth Analg (Cleve)"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cpt1978233281","article-title":"Hemodynamic and respiratory effects of morphine and butorphanol","volume":"23","author":"Popio, K.A.; Jackson, D.H.; Ross, A.M.; Schaeiner, B.F.; Yu, P.N.","year":"1978","unstructured":"Popio KA, Jackson DH, Ross AM, Schaeiner BF, Yu PN. Hemodynamic and respiratory effects of morphine and butorphanol. Clin Pharmacol Ther 1978;23:281-7.","journal-title":"Clin Pharmacol Ther"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1002\/cpt1978235542","article-title":"Differential effects of morphine on forearm blood flow: attenuation of sympathetic control of the cutaneous circulation","volume":"23","author":"Flaim, S.F.; Zelis, R.; Eisele, J.H.","year":"1978","unstructured":"Flaim SF, Zelis R, Eisele JH. Differential effects of morphine on forearm blood flow: attenuation of sympathetic control of the cutaneous circulation. Clin Pharmacol Ther 1978;23:542-6.","journal-title":"Clin Pharmacol Ther"},{"key":"ref_17","first-page":"777","article-title":"Treatment for heart failure: stimulation or unloading?","volume":"ii:","author":"Anonymous","year":"1979","unstructured":"Anonymous. Treatment for heart failure: stimulation or unloading? Lancet 1979;ii:777-9.","journal-title":"Lancet"},{"key":"ref_18","article-title":"The pharmacological basis of therapeutics","author":"Goodman, L.S.; Gilman, A.","year":"1975","unstructured":"Goodman LS, Gilman A. The pharmacological basis of therapeutics. New York: Macmillan, 1975."},{"key":"ref_19","article-title":"Accepted","year":"1980","unstructured":"(Accepted 1 February 1980)"},{"key":"ref_20","article-title":"head of drug allergy and autoimmunity unit Case report A 69-year-old woman was admitted to hospital in 1976 with cholestatic jaundice. One month before she had been treated with nitrofurantoin for a urinary tract infection. Pneumonia was then suspected and she was given ampicillin and cloxacillin. Two weeks before admission she had begun to itch, and a few days later jaundice appeared","author":"ELLA LIVNI, PHD","unstructured":"ELLA LIVNI, PHD, head of drug allergy and autoimmunity unit Case report A 69-year-old woman was admitted to hospital in 1976 with cholestatic jaundice. One month before she had been treated with nitrofurantoin for a urinary tract infection. Pneumonia was then suspected and she was given ampicillin and cloxacillin. Two weeks before admission she had begun to itch, and a few days later jaundice appeared."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6219.980","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6219.980","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T19:58:12Z","timestamp":1765396692000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6219.980"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,4,5]]},"references-count":20,"journal-issue":{"issue":"6219","published-online":{"date-parts":[[1980,4,5]]},"published-print":{"date-parts":[[1980,4,5]]}},"alternative-id":["10.1136\/bmj.280.6219.980"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6219.980","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,4,5]]}}}