{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T06:38:13Z","timestamp":1770964693665,"version":"3.50.1"},"reference-count":26,"publisher":"BMJ","issue":"6225","license":[{"start":{"date-parts":[[1980,5,17]],"date-time":"1980-05-17T00:00:00Z","timestamp":327369600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,5,17]]},"abstract":"<jats:p>A double-blind trial of Org OD 14, a synthetic steroid with an unusual endocrine profile, was conducted on 100 postmenopausal women; of these, 63 completed two years' treatment (33 Org OD 14; 30 placebo). A dose of 2.5 mg\/day successfully prevented bone loss over two years, whereas a significant reduction in bone mineral content occurred in women taking placebo, the rate being comparable to that in earlier studies (p less than 0.01). At the dosage used (2.5 mg\/day) Org OD 14 also significantly reduced the severity of menopausal complaints (flushing, sweating, etc). Vabra aspiration curettage in 20 cases 6-18 months after starting active treatment showed no evidence of endometrial hyperplasia, though weak proliferation of the endometrium was seen in three. Org OD 14 may provide a new approach to hormonal prevention of bone loss in postmenopausal women without inducing appreciable endometrial stimulation; the potential value of Org OD 14 in osteoporosis and other post-climacteric complaints warrants further investigation.<\/jats:p>","DOI":"10.1136\/bmj.280.6225.1207","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1207-1209","source":"Crossref","is-referenced-by-count":117,"title":["Prospective double-blind trial of synthetic steroid (Org OD 14) for preventing postmenopausal osteoporosis."],"prefix":"10.1136","volume":"280","author":[{"given":"R","family":"Lindsay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D M","family":"Hart","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kraszewski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,5,17]]},"reference":[{"key":"ref_1","first-page":"1038","article-title":"Long-term prevention ofpostmenopausal osteoporosis by oestrogen","volume":"i:","author":"Lindsay, R.; Hart, D.M.; Aitken, J.M.; MacDonald, E.B.; Anderson, J.B.; Clarke, A.C.","year":"1976","unstructured":"Lindsay R, Hart DM, Aitken JM, MacDonald EB, Anderson JB, Clarke AC. 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Maturitas 1978;1:107-12.","journal-title":"Maturitas"},{"key":"ref_8","first-page":"193","article-title":"Comparative effects of oestrogen and a progestogen on bone loss in postmenopausal women","volume":"54","author":"Lindsay, R.; Hart, D.M.; Purdie, D.; Ferguson, M.M.; Clark, A.S.; Kraszewski, A.","year":"1978","unstructured":"Lindsay R, Hart DM, Purdie D, Ferguson MM, Clark AS, Kraszewski A. Comparative effects of oestrogen and a progestogen on bone loss in postmenopausal women. Clin Sci Mol Med 1978;54:193-5.","journal-title":"Clin Sci Mol Med"},{"key":"ref_9","first-page":"174","article-title":"Vascular complications of long-term oestrogen therapy","volume-title":"therapy: the benefits and risks","author":"Hart, D.M.; Lindsay, R.; Purdie, D.","year":"1978","unstructured":"Hart DM, Lindsay R, Purdie D. Vascular complications of long-term oestrogen therapy. In: Lauritzen C, Van Keep PA, eds. Estrogen therapy: the benefits and risks. Basle: Karger, 1978:174-91. (Front Horm Res, 5.)"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/S0009-9260(72)80133-8","article-title":"The accuracy and reproducibility of bone mineral measurements \"in vivo\": (a) the measurement of metacarpal mineralisation using an x-ray generator","volume":"23","author":"Shimmins, J.; Anderson, J.B.; Smith, D.A.; Aitken, M.","year":"1972","unstructured":"Shimmins J, Anderson JB, Smith DA, Aitken M. The accuracy and reproducibility of bone mineral measurements \"in vivo\": (a) the measurement of metacarpal mineralisation using an x-ray generator. Clin Radiol 1972;23:42-6.","journal-title":"Clin Radiol"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0009-9260(72)80135-1","article-title":"The accuracy and reproducibility of bone mineral measurements \"in vivo\": (b) methods using sealed isotope sources","volume":"23","author":"Shimmins, J.; Smith, D.A.; Aitken, M.; Anderson, J.B.; Gillespie, F.C.","year":"1972","unstructured":"Shimmins J, Smith DA, Aitken M, Anderson JB, Gillespie FC. The accuracy and reproducibility of bone mineral measurements \"in vivo\": (b) methods using sealed isotope sources. Clin Radiol 1972;23:47-51.","journal-title":"Clin Radiol"},{"key":"ref_12","first-page":"21","article-title":"Radiological determination of changes in bone mineral content","volume":"44","author":"Lindsay, R.; Anderson, J.B.","year":"1978","unstructured":"Lindsay R, Anderson JB. Radiological determination of changes in bone mineral content. 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Determination of hydroxyproline. Clin Chim Acta 1967;18:267-73.","journal-title":"Clin Chim Acta"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1001\/archinte.1953.00240180101012","article-title":"Vitamin E and climacteric syndrome: failure of effective control as measured by menopausal index","volume":"91","author":"Blatt, M.H.; Wiesbader, H.; Kupperman, H.S.","year":"1953","unstructured":"Blatt MH, Wiesbader H, Kupperman HS. Vitamin E and climacteric syndrome: failure of effective control as measured by menopausal index. Arch Intern Med 1953;91:792-9.","journal-title":"Arch Intern Med"},{"key":"ref_17","first-page":"1575","article-title":"Relations between bleeding pattern, endometrial histology, and oestrogen treatment in menopausal women","volume":"i:","author":"Sturdee, D.W.; Wade-Evans, T.; Paterson, M.E.; Thom, M.; Studd, J.W.","year":"1978","unstructured":"Sturdee DW, Wade-Evans T, Paterson ME, Thom M, Studd JW. 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The role of estrogenl progestogen in the management of the menopause. Lancaster: MTP Press, 1978;9-27."},{"key":"ref_20","first-page":"370","article-title":"The interrelationships between bone mineral at different skeletal sites in male and female cadavera","volume":"56","author":"Aitken, J.M.; Smith, C.B.; Horton, P.W.; Clark, D.L.; Boyd, J.F.; Smith, D.A.","year":"1974","unstructured":"Aitken JM, Smith CB, Horton PW, Clark DL, Boyd JF, Smith DA. The interrelationships between bone mineral at different skeletal sites in male and female cadavera. J Bone Joint Surg [Br] 1974;56:370-5.","journal-title":"J Bone Joint Surg [Br]"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1001\/jama.1959.03010300011002","article-title":"Prolonged estrogen therapy in postmenopausal women","volume":"171","author":"Wallach, S.; Henneman, P.H.","year":"1959","unstructured":"Wallach S, Henneman PH. Prolonged estrogen therapy in postmenopausal women. JAMA 1959;171:1637-42.","journal-title":"JAMA"},{"key":"ref_22","first-page":"326","article-title":"Antifracture efficacy of long-term estrogens for osteoporosis","volume":"86","author":"Gordan, G.S.; Picchi, J.; Roof, B.S.","year":"1973","unstructured":"Gordan GS, Picchi J, Roof BS. Antifracture efficacy of long-term estrogens for osteoporosis. Trans Assoc Am Physicians 1973;86:326-32.","journal-title":"Trans Assoc Am Physicians"},{"key":"ref_23","first-page":"707","article-title":"Post-menopausal oestrogens protect against fractures of hip and distal radius: a case-control study","volume":"ii:","author":"Hutchinson, T.A.; Polansky, S.M.; Feinstein, A.R.","year":"1979","unstructured":"Hutchinson TA, Polansky SM, Feinstein AR. Post-menopausal oestrogens protect against fractures of hip and distal radius: a case-control study. Lancet 1979;ii:707-9.","journal-title":"Lancet"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0378-5122(79)90018-5","article-title":"Bone loss during oestriol therapy in postmenopausal women","volume":"1","author":"Lindsay, R.; Hart, D.M.; MacLean, A.; Garwood, J.; Clark, A.C.; Kraszewski, A.","year":"1979","unstructured":"Lindsay R, Hart DM, MacLean A, Garwood J, Clark AC, Kraszewski A. Bone loss during oestriol therapy in postmenopausal women. Maturitas 1979;1:279-85.","journal-title":"Maturitas"},{"key":"ref_25","article-title":"Accepted 3","year":"1979","unstructured":"(Accepted 3 December 1979)"},{"key":"ref_26","first-page":"p","article-title":"ONE HUNDRED YEARS AGO The following interesting case, recorded by Professor H. 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Fischer in the Deutsche Med Wochenschrift, October 25th, 1879, is compared by Dr Napier with one communicated to the Glasgow Medical_Journal in 1879, p 222, by Dr Dove M'Calman."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.280.6225.1207","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.280.6225.1207","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T20:19:47Z","timestamp":1765397987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.280.6225.1207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,5,17]]},"references-count":26,"journal-issue":{"issue":"6225","published-online":{"date-parts":[[1980,5,17]]},"published-print":{"date-parts":[[1980,5,17]]}},"alternative-id":["10.1136\/bmj.280.6225.1207"],"URL":"https:\/\/doi.org\/10.1136\/bmj.280.6225.1207","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,5,17]]}}}