{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T18:38:10Z","timestamp":1779907090906,"version":"3.53.1"},"reference-count":15,"publisher":"BMJ","issue":"6235","license":[{"start":{"date-parts":[[1980,7,26]],"date-time":"1980-07-26T00:00:00Z","timestamp":333417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,7,26]]},"abstract":"<jats:p>A case of haemoglobin Bart's hydrops syndrome was characterised in a Greek family with a history of three other fetuses with hydrops. Family studies showed that both the mother and father carried alpha-thalassaemia genes, and globin-chain synthesis analysis of the present fetus showed a total absence of alpha-chain production. The haemoglobin composition of the fetus was similar to that seen in cases in south-east Asia, and analysis of DNA from the Greek case confirmed the total deletion of the alpha-chain genes. The extent of the deletion, however, differed from that seen in south-east Asian cases and included the loss of one of the embryonic zeta-chain genes. Thus the severe form of alpha-thalassaemia occurs in Greece but has arisen independently from the similar condition in south-east Asia. The condition must be considered in any woman of this racial background who gives a history of unexplained stillbirths.<\/jats:p>","DOI":"10.1136\/bmj.281.6235.268","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"268-270","source":"Crossref","is-referenced-by-count":18,"title":["Haemoglobin Bart's hydrops syndrome in Greece."],"prefix":"10.1136","volume":"281","author":[{"given":"C","family":"Kattamis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Metaxotou-Mavromati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Tsiarta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Metaxatou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Wasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W G","family":"Wood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Pressley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D R","family":"Higgs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J B","family":"Clegg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D J","family":"Weatherall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,7,26]]},"reference":[{"key":"ref_1","first-page":"383","article-title":"The cx thalassaemias","volume":"3","author":"Wasi, P.; Na-Nakorn, S.; Pootrakul, S.","year":"1974","unstructured":"Wasi P, Na-Nakorn S, Pootrakul S. 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MedJ7 Austr","volume":"ii:","author":"Sharma, R.S.; Yu, V.; Walters, W.A.W.","year":"1979","unstructured":"Sharma RS, Yu V, Walters WAW. Haemoglobin Bart's hydrops fetalis syndrome in an infant of Greek origin and prenatal diagnosis of alpha-thalassaemia. MedJ7 Austr 1979;ii:404-34."},{"key":"ref_8","article-title":"The thalassaemia syndromes","author":"Weatherall, D.J.; Clegg, J.B.","year":"1972","unstructured":"Weatherall DJ, Clegg JB. The thalassaemia syndromes. 2nd ed. Oxford: Blackwell Scientific Publications, 1972.","edition":"2nd ed"},{"key":"ref_9","first-page":"251","article-title":"The pattern of disordered haemoglobin synthesis in homozygous and heterozygous P3 thalassaemia","volume":"16","author":"Weatherall, D.J.; Clegg, J.B.; Na-Nakorn, S.; Wasi, P.","year":"1969","unstructured":"Weatherall DJ, Clegg JB, Na-Nakorn S, Wasi P. The pattern of disordered haemoglobin synthesis in homozygous and heterozygous P3 thalassaemia. 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