{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T21:46:19Z","timestamp":1765403179860,"version":"3.46.0"},"reference-count":6,"publisher":"BMJ","issue":"6239","license":[{"start":{"date-parts":[[1980,8,23]],"date-time":"1980-08-23T00:00:00Z","timestamp":335836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,8,23]]},"abstract":"<jats:p>So far IgE monoclonal paraproteins have been found only in patients with malignant diseases, though there are benign monoclonal paraproteins of other immunoglobulin classes. A patient with osteoporosis first seen in Paris in 1965 was found to have a paraprotein type lambda. In 1977 immunoelectrophoresis identified this as IgE lambda paraprotein, and immunodiffusion studies showed precipitin bands identical with those in patients with IgE myeloma. This patient seemed to have a benign monoclonal IgE gammopathy which had existed for 14 years. Though the possibility of transition into multiple myeloma cannot be excluded, this case suggests that a monoclonal expansion of IgE lymphocytes need not produce malignant change.<\/jats:p>","DOI":"10.1136\/bmj.281.6239.539","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"539-540","source":"Crossref","is-referenced-by-count":13,"title":["\"Benign\" monoclonal IgE gammopathy."],"prefix":"10.1136","volume":"281","author":[{"given":"H","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W","family":"Vormittag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,8,23]]},"reference":[{"issue":"281","key":"ref_1","first-page":"1217","article-title":"Clinical aspects of IgE myeloma. 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Allergol Immunopathol 1978;6:423-6.","journal-title":"Allergol Immunopathol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/j.1600-0609.1978.tb00367.x","article-title":"Waldenstrom's macroglobulinaemia with IgE -M-component","volume":"21","author":"Shirakura, T.; Takekoshi, K.; Umi, M.; Kanazawa, K.; Okabe, H.; Inoue, T.; Imamura, Y.","year":"1978","unstructured":"Shirakura T, Takekoshi K, Umi M, Kanazawa K, Okabe H, Inoue T, Imamura Y. Waldenstrom's macroglobulinaemia with IgE -M-component. ScandJ Haematol 1978;21:292-8.","journal-title":"ScandJ Haematol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000207936","article-title":"Monoclonal gammopathy of IgA and IgE type in a case of chronic lymphatic leukaemia","volume":"56","author":"Baenkler, H.W.","year":"1976","unstructured":"Baenkler HW. Monoclonal gammopathy of IgA and IgE type in a case of chronic lymphatic leukaemia. Acta Haematol 1976;56:67-73.","journal-title":"Acta Haematol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1001\/jama.1973.03220310018004","article-title":"Chronic acral dermatitis. Association with extreme elevation of IgE","volume":"225","author":"Winkelman, R.K.; Gleich, G.J.","year":"1973","unstructured":"Winkelman RK, Gleich GJ. Chronic acral dermatitis. Association with extreme elevation of IgE.JAMA 1973;225:378-81.","journal-title":"JAMA"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6239.539","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6239.539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T21:41:43Z","timestamp":1765402903000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6239.539"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,8,23]]},"references-count":6,"journal-issue":{"issue":"6239","published-online":{"date-parts":[[1980,8,23]]},"published-print":{"date-parts":[[1980,8,23]]}},"alternative-id":["10.1136\/bmj.281.6239.539"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6239.539","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,8,23]]}}}