{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:38:59Z","timestamp":1765456739718,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6243","license":[{"start":{"date-parts":[[1980,9,20]],"date-time":"1980-09-20T00:00:00Z","timestamp":338256000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,9,20]]},"abstract":"<jats:p>A three-year study (1977-9) of primary biliary cirrhosis in the city of Sheffield disclosed 34 cases, a point prevalence of 54 per million population. Closer inspection showed an apparent clustering of cases, and the prevalence in relation to one water reservoir appeared to be more than ten times that of the other reservoirs. Nevertheless, analyses of the water showed no significant relevant differences between the reservoir serving areas with a high prevalence of cirrhosis and other reservoirs. Despite the inconclusive results of the water analyses, these findings do suggest that an environmental agent may be a cause of primary biliary cirrhosis and that further epidemiological studies may help to elucidate the cause.<\/jats:p>","DOI":"10.1136\/bmj.281.6243.772","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"772-775","source":"Crossref","is-referenced-by-count":142,"title":["Primary biliary cirrhosis: an epidemiological study."],"prefix":"10.1136","volume":"281","author":[{"given":"D R","family":"Triger","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,9,20]]},"reference":[{"key":"ref_1","first-page":"533","article-title":"Mitochondrial antibody in primary biliary cirrhosis and other diseases","volume":"77","author":"Klatskin, G.; Kantor, F.S.","year":"1972","unstructured":"Klatskin G, Kantor FS. Mitochondrial antibody in primary biliary cirrhosis and other diseases. Ann Int Med 1972;77:533-41."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1056\/NEJM197309272891306","article-title":"The presentation and diagnosis of 100 patients with primary biliary cirrhosis","volume":"289","author":"Sherlock, S.; Scheuer, P.J.","year":"1973","unstructured":"Sherlock S, Scheuer PJ. The presentation and diagnosis of 100 patients with primary biliary cirrhosis. N Engly Med 1973;289:674-8.","journal-title":"N Engly Med"},{"key":"ref_3","first-page":"136","article-title":"Theoretical statistics","author":"Cox, D.R.; Hinkley, D.V.","year":"1974","unstructured":"Cox DR, Hinkley DV. Theoretical statistics. London: Chapman-Hall, 1974:136-7."},{"key":"ref_4","first-page":"230","article-title":"Primary biliary cirrhosis and coeliac disease","volume":"i:","author":"Logan, R.A.F.; Ferguson, A.; Finlayson, N.D.C.; Weir, D.G.","year":"1978","unstructured":"Logan RAF, Ferguson A, Finlayson NDC, Weir DG. Primary biliary cirrhosis and coeliac disease. Lancet 1978;i:230-3.","journal-title":"Lancet"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bmj.2.6096.1195","article-title":"Primary biliary cirrhosis in mother and daughter","volume":"ii:","author":"Fagan, E.; Cox, S.; Williams, R.","year":"1977","unstructured":"Fagan E, Cox S, Williams R. Primary biliary cirrhosis in mother and daughter. Br Med J 1977;ii:1195.","journal-title":"Br Med J"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0016-5085(76)80208-9","article-title":"Immunological studies in familial primary biliary cirrhosis","volume":"71","author":"Tong, M.J.; Nies, K.M.; Reynolds, T.B.; Quismorio, F.P.","year":"1976","unstructured":"Tong MJ, Nies KM, Reynolds TB, Quismorio FP. Immunological studies in familial primary biliary cirrhosis. Gastroenterology 1976;71:305-7.","journal-title":"Gastroenterology"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1136\/bmj.2.6187.419","article-title":"Are increased individual susceptibility and environmental factors both necessary for the development of primary biliary cirrhosis?","volume":"ii:","author":"Douglas, J.G.; Finlayson, N.D.C.","year":"1979","unstructured":"Douglas JG, Finlayson NDC. Are increased individual susceptibility and environmental factors both necessary for the development of primary biliary cirrhosis? Br Med J 1979;ii:419-20.","journal-title":"Br Med J"},{"key":"ref_8","first-page":"954","article-title":"Is copper hepatotoxic in primary biliary cirrhosis ?","volume":"1","year":"1979","unstructured":"Epstein 0, Arborgh B, Wroblewski R, Segiv M, Scheuer PJ, Sherlock S. Is copper hepatotoxic in primary biliary cirrhosis ? Gut 1979;1O:A954.","journal-title":"Gut"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1016\/S0016-5085(19)32704-0","article-title":"Copper and primary biliary cirrhosis","volume":"67","author":"Fleming, C.R.; Dickson, E.R.; Bagenstoss, A.H.; McCall, J.T.","year":"1974","unstructured":"Fleming CR, Dickson ER, Bagenstoss AH, McCall JT. Copper and primary biliary cirrhosis. Gastroenterology 1974;67:1182-7.","journal-title":"Gastroenterology"},{"key":"ref_10","first-page":"657","article-title":"Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis","volume":"ii:","author":"Platts, M.M.; Goode, G.C.; Hislop, J.S.","year":"1977","unstructured":"Platts MM, Goode GC, Hislop JS. Composition of the domestic water supply and the incidence of fractures and encephalopathy in patients on home dialysis. 3r MedJ3 1977;ii:657-60.","edition":"3r MedJ3"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1136\/gut.15.6.473","article-title":"The epidemiology of primary biliary cirrhosis: a survey of mortality in England and Wales","volume":"15","author":"Hamlyn, A.N.; Sherlock, S.","year":"1976","unstructured":"Hamlyn AN, Sherlock S. The epidemiology of primary biliary cirrhosis: a survey of mortality in England and Wales. Gut 1976;15:473-9.","journal-title":"Gut"},{"author":"Accepted 283July 1980)","key":"ref_12","unstructured":"(Accepted 283July 1980)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6243.772","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6243.772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:36:57Z","timestamp":1765456617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6243.772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9,20]]},"references-count":12,"journal-issue":{"issue":"6243","published-online":{"date-parts":[[1980,9,20]]},"published-print":{"date-parts":[[1980,9,20]]}},"alternative-id":["10.1136\/bmj.281.6243.772"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6243.772","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,9,20]]}}}