{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T07:27:46Z","timestamp":1780471666836,"version":"3.54.1"},"reference-count":15,"publisher":"BMJ","issue":"6244","license":[{"start":{"date-parts":[[1980,9,27]],"date-time":"1980-09-27T00:00:00Z","timestamp":338860800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,9,27]]},"abstract":"<jats:p>Out of 20 relapses that occurred in patients with Wegener's granulomatosis, nine were provoked by bacterial or viral infection. Seven of these occurred during maintenance treatment in response to infection with common pathogens, and treatment of the infection alone was insufficient to produce remission. Circulating immune complexes were seen only in relapses due to infection and rarely in infections that occurred without relapse. A possible mechanism for infection-provoked relapses is that infection-derived complexes reactivate disease; alternatively, the acute-phase or cellular response to infection may enhance quiescent disease. Infection may exacerbate Wegener's granulomatosis and other autoallergic diseases, but whether it does so by a common mechanism is not known and further study is required.<\/jats:p>","DOI":"10.1136\/bmj.281.6244.836","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"836-838","source":"Crossref","is-referenced-by-count":166,"title":["Relapses in Wegener's granulomatosis: the role of infection."],"prefix":"10.1136","volume":"281","author":[{"given":"A J","family":"Pinching","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A J","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B A","family":"Pussell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Lockwood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R S","family":"Mitchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D K","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,9,27]]},"reference":[{"key":"ref_1","first-page":"723","article-title":"Enhanced allergic tissue injury in Goodpasture's syndrome by intercurrent bacterial infection","volume":"ii:","author":"Rees, A.J.; Lockwood, C.M.; Peters, D.K.","year":"1977","unstructured":"Rees AJ, Lockwood CM, Peters DK. Enhanced allergic tissue injury in Goodpasture's syndrome by intercurrent bacterial infection. Br MedJ3 1977;ii:723-6."},{"key":"ref_2","article-title":"Lupus erythematosus","author":"Dubois, E.L.","year":"1974","unstructured":"Dubois EL. Lupus erythematosus. 2nd ed. Los Angeles: University of South California Press, 1974.","edition":"2nd ed"},{"key":"ref_3","first-page":"419","article-title":"Do mild infections trigger the rejection of renal allografts ?","volume-title":"Transplant Proc 1970; 2","author":"Simmons, R.L.; Weil, R.; Tallent, M.B.; Kjellstrand, C.M.; Najarian, J.S.","unstructured":"Simmons RL, Weil R, Tallent MB, Kjellstrand CM, Najarian JS. Do mild infections trigger the rejection of renal allografts ? Transplant Proc 1970;2:419-23."},{"key":"ref_4","first-page":"257","article-title":"Viral syndromes and renal homograft rejection","volume":"175","author":"David, D.S.; Millian, S.J.; Whitsell, J.C.","year":"1972","unstructured":"David DS, Millian SJ, Whitsell JC, et al. Viral syndromes and renal homograft rejection. Ann Surg 1972;175:257-9."},{"key":"ref_5","first-page":"520","article-title":"Viral infections and renal transplant rejection. Br MedJ'","volume":"iv:","author":"Briggs, J.D.; Timbury, M.C.; Paton, A.M.; Bell, P.R.F.","year":"1972","unstructured":"Briggs JD, Timbury MC, Paton AM, Bell PRF. Viral infections and renal transplant rejection. Br MedJ' 1972;iv:520-2."},{"key":"ref_6","first-page":"803","article-title":"Role of virus infections in immunosuppressed renal","volume-title":"transplant patients. Transplant Proc 1973; 5","author":"Lopes, C.; Simmons, R.L.; Mauer, M.; Park, B.; Najarian, J.S.; Good, R.A.","unstructured":"Lopes C, Simmons RL, Mauer M, Park B, Najarian JS, Good RA. Role of virus infections in immunosuppressed renal transplant patients. Transplant Proc 1973;5:803-8."},{"key":"ref_7","first-page":"483","article-title":"Streptococcal infection as a cause of hyperacute renal","volume-title":"allograft rejection. Transplant Proc","volume":"10","author":"Dossetor, J.B.; Schlant, J.; Olson, L.A.; Zabriskie, J.B.","year":"1978","unstructured":"Dossetor JB, Schlant J, Olson LA, Zabriskie JB. Streptococcal infection as a cause of hyperacute renal allograft rejection. Transplant Proc 1978; 10:483-7."},{"key":"ref_8","first-page":"1167","article-title":"Association between Streptococcus faecalis urinary infections and graft rejection in kidney transplantation","volume":"ii:","author":"Byrd, L.H.; Tapin, L.; Cheigh, J.S.; Aronian, J.; Stenzel, K.H.; Rubin, A.L.","year":"1978","unstructured":"Byrd LH, Tapin L, Cheigh JS, Aronian J, Stenzel KH, Rubin AL. Association between Streptococcus faecalis urinary infections and graft rejection in kidney transplantation. Lancet 1978;ii:1167-9.","journal-title":"Lancet"},{"key":"ref_9","first-page":"359","article-title":"Value of immune complex assays in diagnosis and management","volume":"ii:","author":"Pussell, B.A.; Lockwood, C.M.; Scott, D.M.; Pinching, A.J.; Peters, D.K.","year":"1978","unstructured":"Pussell BA, Lockwood CM, Scott DM, Pinching AJ, Peters DK. Value of immune complex assays in diagnosis and management. Lancet 1978;ii:359-63.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1056\/NEJM197612162952502","article-title":"Detection of intrapulmonary haemorrhage by carbon monoxide uptake: a new method and its application in Goodpasture's syndrome","volume":"295","author":"Ewan, P.W.; Jones, H.A.; Rhodes, C.G.; Hughes, J.M.B.","year":"1976","unstructured":"Ewan PW, Jones HA, Rhodes CG, Hughes JMB. Detection of intrapulmonary haemorrhage by carbon monoxide uptake: a new method and its application in Goodpasture's syndrome. N Engl J Med 1976;295: 1391-6.","journal-title":"N Engl J Med"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"660","DOI":"10.7326\/0003-4819-89-5-660","article-title":"The spectrum of vasculitis","volume":"89","author":"Fauci, A.S.; Haynes, B.K.; Katz, P.","year":"1978","unstructured":"Fauci AS, Haynes BK, Katz P. The spectrum of vasculitis. Ann Int Med 1978;89:660-76.","journal-title":"Ann Int Med"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1056\/NEJM197903083001003","article-title":"Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange","volume":"300","author":"Lockwood, C.M.; Worrledge, S.; Nicholas, A.; Cotton, C.; Peters, D.K.","year":"1979","unstructured":"Lockwood CM, Worrledge S, Nicholas A, Cotton C, Peters DK. Reversal of impaired splenic function in patients with nephritis or vasculitis (or both) by plasma exchange. N EnglJ3 Med 1979;300:524-30.","journal-title":"N EnglJ3 Med"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1056\/NEJM197903083001002","article-title":"Defective reticulo-endothelial system Fc-receptor function in systemic lupus erythematosus","volume":"300","author":"Frank, M.M.; Hamburger, M.I.; Lawley, T.J.; Kimberly, R.D.; Plotz, P.H.","year":"1979","unstructured":"Frank MM, Hamburger MI, Lawley TJ, Kimberly RD, Plotz PH. Defective reticulo-endothelial system Fc-receptor function in systemic lupus erythematosus. N EnglJ7 Med 1979;300:518-23.","journal-title":"N EnglJ7 Med"},{"key":"ref_14","article-title":"Accepted","year":"1980","unstructured":"(Accepted 8 August 1980)"},{"key":"ref_15","article-title":"Recurrent abdominal pain associated with digoxin in a patient undergoing maintenance haemodialysis In addition to its inotropic effect on the heart digitalis is a direct peripheral vasoconstrictor.1 In particular, cardiac glycosides cause splanchnic vasoconstriction and reduced mesenteric blood flow in dogs,2 monkeys,3 and variably in patients with congestive heart failure.4 There is a well-recognised association of administration of digitalis with intestinal infarction,5 but digitalis has not been associated before with chronic intestinal ischaemia or abdominal angina","unstructured":"Recurrent abdominal pain associated with digoxin in a patient undergoing maintenance haemodialysis In addition to its inotropic effect on the heart digitalis is a direct peripheral vasoconstrictor.1 In particular, cardiac glycosides cause splanchnic vasoconstriction and reduced mesenteric blood flow in dogs,2 monkeys,3 and variably in patients with congestive heart failure.4 There is a well-recognised association of administration of digitalis with intestinal infarction,5 but digitalis has not been associated before with chronic intestinal ischaemia or abdominal angina."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6244.836","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6244.836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:42:16Z","timestamp":1765456936000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6244.836"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,9,27]]},"references-count":15,"journal-issue":{"issue":"6244","published-online":{"date-parts":[[1980,9,27]]},"published-print":{"date-parts":[[1980,9,27]]}},"alternative-id":["10.1136\/bmj.281.6244.836"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6244.836","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,9,27]]}}}