{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:58:46Z","timestamp":1765457926587,"version":"3.46.0"},"reference-count":34,"publisher":"BMJ","issue":"6246","license":[{"start":{"date-parts":[[1980,10,11]],"date-time":"1980-10-11T00:00:00Z","timestamp":340070400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,10,11]]},"abstract":"<jats:p>The use of thyroxine replacement therapy was studied in 2710 patients with a previous diagnosis of either thyrotoxicosis or primary hypothyroidism. The patients, who were treated in five centres, were followed-up continuously using an automated register. Seventy per cent of patients had been prescribed daily doses of thyroxine of 200 microgram or more. The estimated 10-year cumulative incidence of detected undertreatment was 13 . 2% (95% confidence limits 10 . 9-15 .6%). The median cumulative incidence of recognised overtreatment was 6 . 2%. Improved patient education and the dissemination of guidelines to doctors on the use of thyroxine replacement may reduce the incidence of undertreatment or overtreatment.<\/jats:p>","DOI":"10.1136\/bmj.281.6246.969","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"969-971","source":"Crossref","is-referenced-by-count":7,"title":["Thyroxine replacement therapy: prescribing patterns and problems in 2710 patients. Scottish Automated Follow-up Register Group."],"prefix":"10.1136","volume":"281","member":"239","published-online":{"date-parts":[[1980,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1210\/jcem-29-2-231","article-title":"Effects of antithyroid therapy on the LATS and the antithyroglobulin antibodies","volume":"29","author":"Pinchera, A.; Liberti, P.; Martino, E.","year":"1969","unstructured":"Pinchera A, Liberti P, Martino E, et al. Effects of antithyroid therapy on the LATS and the antithyroglobulin antibodies. Jf Clin Endocrinol Metab 1969;29:231-8.","journal-title":"Jf Clin Endocrinol Metab"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1677\/joe.0.0240115","article-title":"The clinical significance of the complement fixation test in thyrotoxicosis","volume":"24","author":"Buchanan, W.W.; Koutras, D.A.; Crooks, J.","year":"1962","unstructured":"Buchanan WW, Koutras DA, Crooks J, et al. The clinical significance of the complement fixation test in thyrotoxicosis. J Endocrinol 1962;24: 115-25.","journal-title":"J Endocrinol"},{"key":"ref_3","first-page":"713","article-title":"Relation of thyroidstimulating immunoglobulins to thyroid function and effects of surgery, radioiodine and antithyroid drugs","volume":"ii:","author":"Mukhtar, E.D.; Rees Smith, B.; Pyle, G.; Hall, R.; Vice, P.","year":"1975","unstructured":"Mukhtar ED, Rees Smith B, Pyle G, Hall R, Vice P. Relation of thyroidstimulating immunoglobulins to thyroid function and effects of surgery, radioiodine and antithyroid drugs. Lancet 1975;ii:713-5.","journal-title":"Lancet"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1210\/jcem-48-4-572","article-title":"Changes in thyroidstimulating immunoglobulins during anti-thyroid therapy","volume":"48","author":"Fenzi, G.; Hashizume, K.; Roudebush, C.P.; De Groot, L.J.","year":"1979","unstructured":"Fenzi G, Hashizume K, Roudebush CP, De Groot LJ. Changes in thyroidstimulating immunoglobulins during anti-thyroid therapy. J Clin Endocrinol Metab 1979;48:572-6.","journal-title":"J Clin Endocrinol Metab"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1365-2265.1979.tb03095.x","article-title":"Effects of radioiodine on thyrotrophin binding inhibiting immunoglobulins in Graves's disease","volume":"11","author":"McGregor, A.M.; Petersen, M.M.; Capiferri, R.; Evered, D.C.; Rees Smith, B.; Hall, R.","year":"1979","unstructured":"McGregor AM, Petersen MM, Capiferri R, Evered DC, Rees Smith B, Hall R. Effects of radioiodine on thyrotrophin binding inhibiting immunoglobulins in Graves's disease. Clin Endocrinol 1979;11:437-44.","journal-title":"Clin Endocrinol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM198008073030603","article-title":"Carbimazole and the autoimmune response in Graves'","volume":"303","author":"McGregor, A.M.; Petersen, M.M.; McLachlan, S.M.; Rooke, P.; Rees Smith, B.; Hall, R.","year":"1980","unstructured":"McGregor AM, Petersen MM, McLachlan SM, Rooke P, Rees Smith B, Hall R. Carbimazole and the autoimmune response in Graves' disease. N EnglJ Med 1980;303:302-7.","journal-title":"disease. N EnglJ Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1136\/jcp.29.12.1054","article-title":"Assessment of thyroid hormone assays","volume":"29","author":"Evered, D.C.; Vice, P.A.; Green, E.C.; Appleton, D.J.","year":"1976","unstructured":"Evered DC, Vice PA, Green EC, Appleton DJ. Assessment of thyroid hormone assays. Y Clin Pathol 1976;29:1054-9.","journal-title":"Y Clin Pathol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1365-2265.1972.tb00383.x","article-title":"The immunoassay of TSH and its clinical applications","volume":"1","author":"Hall, R.","year":"1972","unstructured":"Hall R. The immunoassay of TSH and its clinical applications. Clin Endocrinol 1972; 1:115-9.","journal-title":"Clin Endocrinol"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/jcp.26.8.623","article-title":"Evaluation of a tanned red cell technique for thyroid microsomal antibodies","volume":"26","author":"Bird, T.; Stephenson, J.","year":"1973","unstructured":"Bird T, Stephenson J. Evaluation of a tanned red cell technique for thyroid microsomal antibodies. J Clin Pathol 1973;26:623-7.","journal-title":"J Clin Pathol"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1365-2265.1975.tb01930.x","article-title":"35S-antithyroid drug concentration and organic binding of iodine in the human thyroid","volume":"4","author":"Lazarus, J.H.; Marchant, B.; Alexander, W.D.; Clark, D.H.","year":"1975","unstructured":"Lazarus JH, Marchant B, Alexander WD, Clark DH. 35S-antithyroid drug concentration and organic binding of iodine in the human thyroid. Clin Endocrinol 1975;4:609-15.","journal-title":"Clin Endocrinol"},{"key":"ref_11","first-page":"305","article-title":"Antithyroid drugs","volume":"3","author":"Marchant, B.; Lees, J.F.H.; Alexander, W.D.","year":"1978","unstructured":"Marchant B, Lees JFH, Alexander WD. Antithyroid drugs. Pharmacol Ther 1978;3:305-48.","journal-title":"Pharmacol Ther"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1159\/000231201","article-title":"Identification in the thyroid of antithyroglobulin antibodies in the fibrous variant of Hashimoto's thyroiditis","volume":"47","author":"Salabe, G.B.; Davoli, C.; Andreoli, M.","year":"1974","unstructured":"Salabe GB, Davoli C, Andreoli M. Identification in the thyroid of antithyroglobulin antibodies in the fibrous variant of Hashimoto's thyroiditis. Int Arch Allergy 1974;47:63-79.","journal-title":"Int Arch Allergy"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0090-1229(78)90181-2","article-title":"Distribution of T-, B-and thyroglobulin-binding lymphocytes infiltrating the gland in Graves' disease, Hashimoto's thyroiditis and De Quervain's thyroiditis","volume":"10","author":"Totterman, T.","year":"1978","unstructured":"Totterman, T. Distribution of T-, B-and thyroglobulin-binding lymphocytes infiltrating the gland in Graves' disease, Hashimoto's thyroiditis and De Quervain's thyroiditis. Clin Immunol Immunopathol 1978;10: 270-7.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_14","first-page":"162","article-title":"Thyroid autoantibody synthesis by Hashimoto thyroid lymphocytes","volume":"i:","author":"McLachlan, S.M.; McGregor, A.M.; Rees Smith, B.; Hall, R.","year":"1979","unstructured":"McLachlan SM, McGregor AM, Rees Smith B, Hall R. Thyroid autoantibody synthesis by Hashimoto thyroid lymphocytes. Lancet 1979;i: 162-3.","journal-title":"Lancet"},{"article-title":"Accepted","year":"1980","key":"ref_15","unstructured":"(Accepted 1 September 1980)"},{"key":"ref_16","unstructured":"of hypothyroidism ranged from 24% to 63% in a total of 1902 patients after radioiodine therapy and from 23% to 52% in 1428 patients after subtotal thyroidectomy (unpublished observations).","article-title":"of hypothyroidism ranged from 24% to 63% in a total of 1902 patients after radioiodine therapy and from 23% to 52% in 1428 patients after subtotal thyroidectomy"},{"key":"ref_17","unstructured":"The Scottish Automated Follow-up Register (SAFUR) has been providing follow-up facilities for patients treated for thyroid disease since 1967, as a joint venture between hospital and primary care. The system is used by hospital doctors in five Scottish centres and 1547 general practitioners to follow-up patients treated by radioiodine, subtotal thyroidectomy, and thyroxine replacement. There are now over 6000 patients on the register. Follow-up examinations are usually carried out by general practitioners, and biochemical analyses, processing, and reporting of results are performed by a central registry with laboratory and computing facilities.","article-title":"The Scottish Automated Follow-up Register (SAFUR) has been providing follow-up facilities for patients treated for thyroid disease since 1967, as a joint venture between hospital and primary care. The system is used by hospital doctors in five Scottish centres and 1547 general practitioners to follow-up patients treated by radioiodine, subtotal thyroidectomy, and thyroxine replacement. There are now over 6000 patients on the register. Follow-up examinations are usually carried out by general practitioners, and biochemical analyses, processing, and reporting of results are performed by a central registry with laboratory and computing facilities"},{"issue":"29","key":"ref_18","article-title":"Lists of these patients were sent to the centres concerned for checking for possible errors in recording and for appropriate action. In the remaining group of prescriptions only","volume":"861","author":"jg\/day","unstructured":"-500 jg\/day. Lists of these patients were sent to the centres concerned for checking for possible errors in recording and for appropriate action. In the remaining group of prescriptions only 861 (29%0) were for doses in the range of 100 to 150 jg, 1714 (59%)","journal-title":"150; were for doses in the range of 100 to"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1365-2265.1977.tb01340.x","article-title":"The spectrum of thyroid disease in a community: the Whickham survey","volume":"7","author":"Tunbridge, W.M.G.; Evered, D.C.; Hall, R.","year":"1977","unstructured":"Tunbridge WMG, Evered DC, Hall R, et al. The spectrum of thyroid disease in a community: the Whickham survey. Clin Endocrinol 1977; 7:481-93.","journal-title":"Clin Endocrinol"},{"issue":"223","key":"ref_20","article-title":"Report of the Newborn Committee of the European Thyroid Association. Neonatal screening for congenital hypothyroidism in Europe","volume":"90","year":"1979","unstructured":"Report of the Newborn Committee of the European Thyroid Association. Neonatal screening for congenital hypothyroidism in Europe. Acta Endocrinol 1979;90, suppl:223.","journal-title":"Acta Endocrinol"},{"key":"ref_21","first-page":"125","article-title":"Manipulation of the therapeutic regimen to improve compliance: conceptions and misconceptions","volume":"22","author":"Haynes, B.R.; Sackett, D.L.; Taylor, D.W.; Roberts, R.S.; Johnson, A.L.","year":"1977","unstructured":"Haynes BR, Sackett DL, Taylor DW, Roberts RS, Johnson AL. Manipulation of the therapeutic regimen to improve compliance: conceptions and misconceptions. ClGn Pharmacol Therap 1977;22:125-9.","journal-title":"ClGn Pharmacol Therap"},{"key":"ref_22","first-page":"116","article-title":"The problems of compliance in drug therapy","volume-title":"Topics in therapeutics. Vol 3","author":"Crooks, J.; Parkin, D.M.","year":"1978","unstructured":"Crooks J, Parkin DM. The problems of compliance in drug therapy. In: Shanks RG, ed. Topics in therapeutics. Vol 3. London: Pitman Medical, 1978:116-31."},{"key":"ref_23","first-page":"519","article-title":"The surgical treatment of thyrotoxicosis","volume":"i:","author":"Hedley, A.J.; Flemming, C.; Chesters, M.I.; Michie, W.; Crooks, J.","year":"1970","unstructured":"Hedley AJ, Flemming C, Chesters MI, Michie W, Crooks J. The surgical treatment of thyrotoxicosis. Br MedJ7 1970;i:519-23."},{"issue":"8","key":"ref_24","first-page":"67","article-title":"A computer assisted follow-up register","volume":"1969","author":"Hedley, A.J.; Scott, A.M.; Debenham, G.","unstructured":"Hedley AJ, Scott AM, Debenham G. A computer assisted follow-up register. Methods Inf Med 1969;8:67-77.","journal-title":"Methods Inf Med"},{"key":"ref_25","first-page":"556","article-title":"Computer-assisted follow-up register for the North East of Scotland","volume":"i:","author":"Hedley, A.J.; Scott, A.M.; Weir, R.D.; Crooks, J.","year":"1970","unstructured":"Hedley AJ, Scott AM, Weir RD, Crooks J. Computer-assisted follow-up register for the North East of Scotland. Br MedJ7 1970;i:556-8."},{"key":"ref_26","first-page":"340","article-title":"Statistics with applications to the biological and health sciences","author":"Remington, R.D.; Schork, M.A.","year":"1970","unstructured":"Remington RD, Schork MA. Statistics with applications to the biological and health sciences. New Jersey: Prentice Hall, 1970:340-9."},{"key":"ref_27","first-page":"131","article-title":"Treatment of hypothyroidism: a reappraisal of thyroxine therapy","volume":"iii:","author":"Evered, D.C.; Young, E.T.; Ormston, B.J.; Menzies, R.; Smith, P.A.; Hall, R.","year":"1973","unstructured":"Evered DC, Young ET, Ormston BJ, Menzies R, Smith PA, Hall R. Treatment of hypothyroidism: a reappraisal of thyroxine therapy. Br MedJ7 1973;iii:131-4."},{"key":"ref_28","first-page":"530","article-title":"Replacement dosage of Lthyroxine in hypothyroidism","volume":"290","author":"Stock, J.M.; Surks, M.I.; Oppenheimer, J.H.","year":"1974","unstructured":"Stock JM, Surks MI, Oppenheimer JH. Replacement dosage of Lthyroxine in hypothyroidism. N Engl Med 1974;290:530-3.","journal-title":"N Engl Med"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1111\/j.0954-6820.1977.tb16823.x","article-title":"Studies on replacement and suppressive dosages of Lthyroxine","volume":"202","author":"Nilsson, G.","year":"1977","unstructured":"Nilsson G, et al. Studies on replacement and suppressive dosages of Lthyroxine. Acta Med Scand 1977;202:257-60.","journal-title":"Acta Med Scand"},{"article-title":"Association of the British Pharmaceutical Industry. Data compendium 1980","year":"1980","key":"ref_30","unstructured":"Association of the British Pharmaceutical Industry. Data compendium 1980. London: ABPI, 1980."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0002-9343(78)90057-8","article-title":"Why does anyone still use desiccated thyroid USP ?","volume":"64","author":"Jackson, I.M.D.; Cobb, W.E.","year":"1978","unstructured":"Jackson IMD, Cobb WE. Why does anyone still use desiccated thyroid USP ? Am J Med 1978;64:284-8.","journal-title":"Am J Med"},{"key":"ref_32","article-title":"Thyroid extract","author":"Hoff, W.Van't","year":"1978","unstructured":"W Van't Hoff, et al. Thyroid extract. Br MedJ 1978;ii:200.","journal-title":"Br MedJ"},{"key":"ref_33","first-page":"855","article-title":"to triiodothyronine (T3) in athyreotic human subjects. J7 Clin Invest","volume":"49","year":"1970","unstructured":"to triiodothyronine (T3) in athyreotic human subjects. J7 Clin Invest 1970;49:855-64."},{"article-title":"Accepted","year":"1980","key":"ref_34","unstructured":"(Accepted 27 August 1980)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6246.969","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6246.969","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:55:03Z","timestamp":1765457703000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6246.969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10,11]]},"references-count":34,"journal-issue":{"issue":"6246","published-online":{"date-parts":[[1980,10,11]]},"published-print":{"date-parts":[[1980,10,11]]}},"alternative-id":["10.1136\/bmj.281.6246.969"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6246.969","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,10,11]]}}}