{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:20:00Z","timestamp":1787062800931,"version":"build-2736575974"},"reference-count":12,"publisher":"BMJ","issue":"6247","license":[{"start":{"date-parts":[[1980,10,18]],"date-time":"1980-10-18T00:00:00Z","timestamp":340675200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,10,18]]},"abstract":"<jats:p>The neuropsychiatric states of 50 patients with vitamin B12 deficiency and 34 patients with folate deficiency presenting with megaloblastosis in a general hospital were examined and compared. Abnormalities of the nervous system were found in two-thirds of both groups. Peripheral neuropathy was the most common condition associated with vitamin B12 deficiency and affective disorder with folate deficiency. The proportions of patients with organic mental change were similar in the two groups. Subacute combined degeneration of the cord was an uncommon complication and occurred only in the patients with vitamin B12 deficiency. There was no relation between haematological and neuropsychiatric abnormalities. The neuropsychiatry of megaloblastic anaemia seen in this study of patients presenting to haematologists or general physicians contrasts with that reported previously, before haematological techniques for separating the two deficiencies were introduced.<\/jats:p>","DOI":"10.1136\/bmj.281.6247.1036","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1036-1038","source":"Crossref","is-referenced-by-count":177,"title":["The neuropsychiatry of megaloblastic anaemia."],"prefix":"10.1136","volume":"281","author":[{"given":"S D","family":"Shorvon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M W","family":"Carney","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Chanarin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E H","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[1980,10,18]]},"reference":[{"key":"ref_1","first-page":"501","article-title":"Interrelations between the neurology of folate and vitamin, B12 deficiency","volume-title":"Folic acid in neurology, psychiatry and internal medicine","author":"Reynolds, E.H.","year":"1979","unstructured":"Reynolds EH. Interrelations between the neurology of folate and vitamin, B12 deficiency. In: Botez MI, Reynolds EH, eds. Folic acid in neurology, psychiatry and internal medicine. New York: Raven Press, 1979:501-15."},{"key":"ref_2","first-page":"1001","article-title":"The neurology of vitamin B,2 deficiency","author":"Reynolds, E.H.","year":"1979","unstructured":"Reynolds EH. The neurology of vitamin B,2 deficiency. In: Zagalak B, Friedrich W, eds. Vitamin B12. Berlin: Walter de Gruyter, 1979: 1001-8."},{"issue":"41","key":"ref_3","first-page":"257","article-title":"Peripheral nerve function in pernicious anaemia before and after treatment","volume":"1969","author":"Lockner, D.; Reizenstein, P.; Wennberg, P.; Widen, L.","unstructured":"Lockner D, Reizenstein P, Wennberg P, Widen L. Peripheral nerve function in pernicious anaemia before and after treatment. Acta Haematol (Basel) 1969;41:257-63.","journal-title":"Acta Haematol (Basel)"},{"key":"ref_4","first-page":"266","article-title":"Psychiatric aspects of pernicious anaemia. A prospective controlled investigation. Br MedJ'","volume":"iii:","author":"Shulman, R.","year":"1966","unstructured":"Shulman R. Psychiatric aspects of pernicious anaemia. A prospective controlled investigation. Br MedJ' 1966;iii:266-70."},{"key":"ref_5","article-title":"Neurological complications in patients with impaired vitamin B,2 absorption following partial gastrectomy","author":"Roos, D.","year":"1978","unstructured":"Roos D. Neurological complications in patients with impaired vitamin B,2 absorption following partial gastrectomy. Acta Neuirol Scanzd [Stuppl] 1978;59[69].","journal-title":"Acta Neuirol Scanzd [Stuppl]"},{"key":"ref_6","article-title":"Folic acid in neurology, psychiatry and internal medicine","author":"Botez, M.I.","year":"1979","unstructured":"Botez MI, Reynolds EH, eds. Folic acid in neurology, psychiatry and internal medicine. New York: Raven Press, 1979."},{"key":"ref_7","first-page":"413","article-title":"Folate deficiency and peripheral neuropathy","volume-title":"Folic acid in neurology, psychiatry and internal medicine","author":"Shorvon, S.D.; Reynolds, E.H.","year":"1979","unstructured":"Shorvon SD, Reynolds EH. Folate deficiency and peripheral neuropathy. In: Botez MI, Reynolds EH, eds. Folic acid in neurology, psychiatry and internal medicine. New York: Raven Press, 1979;413-21."},{"key":"ref_8","first-page":"427","article-title":"Folic acid deficiency: a cause of subacute combined system degeneration","volume-title":"Folic acid in neurology, psychiatry and internal medicine","author":"Pincus, J.H.","year":"1979","unstructured":"Pincus JH. Folic acid deficiency: a cause of subacute combined system degeneration. In: Botez MI, Reynolds EH, eds. Folic acid in neurology, psychiatry and internal medicine. New York: Raven Press, 1979;427-34."},{"key":"ref_9","first-page":"661","article-title":"Neurological aspects of folate and vitamin B1, metabolism Clin Haematol","volume":"5","author":"Reynolds, E.H.","year":"1976","unstructured":"Reynolds EH. Neurological aspects of folate and vitamin B1, metabolism Clin Haematol 1976;5:661-96."},{"key":"ref_10","article-title":"The megaloblastic anaemias","author":"Chanarin, I.","year":"1979","unstructured":"Chanarin I. The megaloblastic anaemias. Oxford: Blackwell, 1979."},{"key":"ref_11","first-page":"285","article-title":"Convulsant properties of folate compounds: some considerations and speculations","volume-title":"Folic acid in neurology, psychiatry and internal medicine","author":"Hommes, O.R.; Hollinger, J.L.; Jansen, M.J.T.; Schoofs, M.; vanderWiel T; Kok, J.C.N.","year":"1979","unstructured":"Hommes OR, Hollinger JL, Jansen MJT, Schoofs M, vanderWiel T, Kok JCN. Convulsant properties of folate compounds: some considerations and speculations. In: Botez MI, Reynolds EH, eds. Folic acid in neurology, psychiatry and internal medicine. New York: Raven Press, 1979;285-316."},{"key":"ref_12","article-title":"Accepted","year":"1980","unstructured":"(Accepted 22 August 1980)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6247.1036","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6247.1036","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T12:56:38Z","timestamp":1765457798000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6247.1036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,10,18]]},"references-count":12,"journal-issue":{"issue":"6247","published-online":{"date-parts":[[1980,10,18]]},"published-print":{"date-parts":[[1980,10,18]]}},"alternative-id":["10.1136\/bmj.281.6247.1036"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6247.1036","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1980,10,18]]}}}