{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:13:21Z","timestamp":1765458801884,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6249","license":[{"start":{"date-parts":[[1980,11,1]],"date-time":"1980-11-01T00:00:00Z","timestamp":341884800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,11,1]]},"abstract":"<jats:p>The effect of long-term treatment with phenobarbitone on pituitary responsiveness to gonadotrophin-releasing hormone and thyrotrophin-releasing hormone was studied in 20 boys being treated with the drug to prevent febrile convulsions. Baseline concentrations of luteinising and follicle-stimulating hormones were reduced as well as the responses of these hormones to stimulation with gonadotrophin-releasing hormone. Baseline prolactin concentrations were raised in comparison with those in normal children. The response of prolactin to thyrotrophin-releasing hormone, however, was impaired only in the children who had been receiving the drug for a long time. Phenobarbitone had no effect on the secretion of growth hormone. Further studies should be carried out to ascertain how long these effects on pituitary function last after phenobarbitone is withdrawn and whether this interference with pituitary function modifies the child's subsequent development.<\/jats:p>","DOI":"10.1136\/bmj.281.6249.1175","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1175-1177","source":"Crossref","is-referenced-by-count":18,"title":["Pituitary responsiveness to gonadotrophin-releasing and thyrotrophin-releasing hormones in children receiving phenobarbitone."],"prefix":"10.1136","volume":"281","author":[{"given":"A","family":"Masala","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Meloni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Alagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P P","family":"Rovasio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Mele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V","family":"Franca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,11,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1651-2227.1977.tb07951.x","article-title":"The effectiveness of phenobarbital in the prevention of recurrent febrile convulsions in children with and without a history of pre-, periand postnatal abnormalities","volume":"66","author":"Wolf, S.M.","year":"1977","unstructured":"Wolf SM. The effectiveness of phenobarbital in the prevention of recurrent febrile convulsions in children with and without a history of pre-, periand postnatal abnormalities. Acta Paediatr Scand 1977;66:585-7.","journal-title":"Acta Paediatr Scand"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1542\/peds.59.3.378","article-title":"The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study","volume":"59","author":"Wolf, S.M.; Carr, A.; Davis, D.C.","year":"1977","unstructured":"Wolf SM, Carr A, Davis DC, et al. The value of phenobarbital in the child who has had a single febrile seizure: a controlled prospective study. 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Proc R Soc Med","volume":"66","author":"McNeily, A.S.","year":"1973","unstructured":"McNeily AS. Radioimmunoassay for human prolactin. Proc R Soc Med 1973;66:683-4."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1159\/000122816","article-title":"Effect of pentobarbital on serum levels of LH, FSH and prolactin in long-term ovariectomized rats","volume":"27","author":"Borrel, J.; Piva, F.; Martini, L.","year":"1978","unstructured":"Borrel J, Piva F, Martini L. Effect of pentobarbital on serum levels of LH, FSH and prolactin in long-term ovariectomized rats. Neuroendocrinology 1978;27:239-46.","journal-title":"Neuroendocrinology"},{"key":"ref_7","first-page":"648","article-title":"Effect of ether and phenobarbital on serum prolactin and LH levels","volume-title":"proestrus rats. Proc Soc Exp Biol Med","volume":"135","author":"Wuttke, W.; Meites, J.","year":"1970","unstructured":"Wuttke W, Meites J. Effect of ether and phenobarbital on serum prolactin and LH levels in proestrus rats. Proc Soc Exp Biol Med 1970;135:648-52."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1007\/BF01923674","article-title":"Inhibition of spontaneous and induced ovulation in rats by non-steroidal agents","volume":"30","author":"Marko, M.; Fluckiger, E.","year":"1974","unstructured":"Marko M, Fluckiger E. Inhibition of spontaneous and induced ovulation in rats by non-steroidal agents. Experientia 1974;30:1174-6.","journal-title":"Experientia"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1677\/joe.0.0650177","article-title":"Reversal by progesterone of phenobarbitalblockade of the ovulation in the prepubertal rat primed with pregnant mare serum gonadotrophin","volume":"65","author":"McCormack, C.E.; Strauss, W.F.","year":"1975","unstructured":"McCormack CE, Strauss WF. Reversal by progesterone of phenobarbitalblockade of the ovulation in the prepubertal rat primed with pregnant mare serum gonadotrophin. J Endocrinol 1975;65:177-82.","journal-title":"J Endocrinol"},{"key":"ref_10","first-page":"285","article-title":"Hyperprolactinaemia and gonadal function: results of bromocriptine treatment","author":"Thorner, M.O.; Besser, G.M.","year":"1977","unstructured":"Thorner MO, Besser GM. Hyperprolactinaemia and gonadal function: results of bromocriptine treatment. In: Crosignani PG, Robyn C, eds. Prolactin and human reproduction. London and New York: Academic Press, 1977:285-301."},{"year":"1980","author":"24","key":"ref_11","unstructured":"(Accepted 24,July 1980)"},{"key":"ref_12","article-title":"Medical","volume":"1880","unstructured":"Medical Journal, 1880.)","journal-title":"Journal"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6249.1175","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6249.1175","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:05:55Z","timestamp":1765458355000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6249.1175"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11,1]]},"references-count":12,"journal-issue":{"issue":"6249","published-online":{"date-parts":[[1980,11,1]]},"published-print":{"date-parts":[[1980,11,1]]}},"alternative-id":["10.1136\/bmj.281.6249.1175"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6249.1175","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,11,1]]}}}