{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:24:25Z","timestamp":1765459465994,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6252","license":[{"start":{"date-parts":[[1980,11,22]],"date-time":"1980-11-22T00:00:00Z","timestamp":343699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,11,22]]},"abstract":"<jats:p>An investigation was carried out in Northern Ireland into the alleged association between fetal abnormalities and Debendox, an antiemetic drug used in pregnancy. During the period 1966-78 the total number of births each year and the overall incidence of congenital malformations per 10 000 births fell. The incidences of cleft lip, cleft palate, reduction deformities, and defects of the heart and great vessels fell from 1966 to 1976 but increased in 1977 and 1978. During the same period (1966-78) the number of prescriptions for Debendox issued by general practitioners increased more than fourfold. These observations suggest that there is no relation between congenital malformations and the use of Debendox. This conclusion, however, does not take into account other drug- or environmental-related factors that may have resulted in a reduction in the number of congenital malformations and would hence have masked an increase associated with greater usage of Debendox. In particular, the amount of Debendox sold direct to the public without a prescription and the use of the drug by patients who were not pregnant could not be established. The amount of drug used in these ways is probably small, and it is difficult to see how it might influence the conclusions reached.<\/jats:p>","DOI":"10.1136\/bmj.281.6252.1379","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1379-1381","source":"Crossref","is-referenced-by-count":30,"title":["Debendox and congenital malformations in Northern Ireland."],"prefix":"10.1136","volume":"281","author":[{"given":"D W","family":"Harron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Griffiths","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Shanks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,11,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/bmj.1.6114.691","article-title":"Unusual fetal malformations after antiemetics in early pregnancy","volume":"i:","author":"Donnai, D.; Harris, R.","year":"1978","unstructured":"Donnai D, Harris R. Unusual fetal malformations after antiemetics in early pregnancy. Br MedJ 1978;i:691-2.","journal-title":"Br MedJ"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2518","DOI":"10.1001\/jama.1979.03300230004002","article-title":"CDC study: no evidence for teratogenecity of Bendectin","volume":"242","author":"Check, W.A.","year":"1979","unstructured":"Check WA. CDC study: no evidence for teratogenecity of Bendectin. JAMA 1979;242:2518.","journal-title":"JAMA"},{"issue":"469","key":"ref_3","first-page":"618","article-title":"Committee on Safety of Medicines. Register of adverse reactions","volume":"320","year":"1976","unstructured":"Committee on Safety of Medicines. Register of adverse reactions. London: Committee on Safety of Medicines, 1976: 320, 469, 618."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/0002-9378(77)90028-X","article-title":"Antenatal exposure to doxylamine succinate and dicyclominehydrochloride (Bendectin) in relation to congenital malformations, perinatal mortality rate, birth weight and intelligence quotient score","volume":"128","author":"Shapiro, S.; Heinonen, O.P.; Siskind, V.; Kaufman, D.W.; Monson, R.R.; Slone, D.","year":"1977","unstructured":"Shapiro S, Heinonen OP, Siskind V, Kaufman DW, Monson RR, Slone D. Antenatal exposure to doxylamine succinate and dicyclominehydrochloride (Bendectin) in relation to congenital malformations, perinatal mortality rate, birth weight and intelligence quotient score. AmJ Obstet Gynecol 1977;128:480-5.","journal-title":"AmJ Obstet Gynecol"},{"key":"ref_5","unstructured":"House of Commons Official Report (Hansard) 1980 April 15;982: col 597-8.","article-title":"House of Commons Official Report (Hansard) 1980 April 15; 982: col 597-8"},{"key":"ref_6","first-page":"109","article-title":"Drugs in use","volume":"224","author":"Anonymous","year":"1980","unstructured":"Anonymous. Drugs in use. PharmaceuticalJournal 1980;224:109-10.","journal-title":"PharmaceuticalJournal"},{"key":"ref_7","first-page":"433","article-title":"Exogenous hormones and other drug exposures of children with congenital heart disease. AmJ'","volume":"109","author":"Rothman, K.J.; Fyler, D.C.; Goldblatt, A.; Kriedberg, M.B.","year":"1979","unstructured":"Rothman KJ, Fyler DC, Goldblatt A, Kriedberg MB. Exogenous hormones and other drug exposures of children with congenital heart disease. AmJ' Epidemiol 1979;109:433-9.","journal-title":"Epidemiol"},{"first-page":"1967","article-title":"Registrar General. 45th-52nd Annual reports of the Registrar General (Northern Ireland) 1966-73","key":"ref_8","unstructured":"Registrar General. 45th-52nd Annual reports of the Registrar General (Northern Ireland) 1966-73. Belfast: HMSO, 1967-75."},{"key":"ref_9","article-title":"Health and personal social services statisticsfor Northern Ireland 1974-6","author":"Department of Health and Social Services","year":"1979","unstructured":"Department of Health and Social Services. Health and personal social services statisticsfor Northern Ireland 1974-6. Belfast: DHSS, 1979."},{"key":"ref_10","first-page":"319","article-title":"A comparison of neural tube defects identified by the independent routine recording systems for congenital malformation","volume-title":"Northern Ireland. Int Epidemiol","volume":"7","author":"Nevin, N.C.; McDonald, JR, Walby; A.L.","year":"1978","unstructured":"Nevin NC, McDonald JR, Walby AL. A comparison of neural tube defects identified by the independent routine recording systems for congenital malformation in Northern Ireland. Int Epidemiol 1978;7: 319-21."},{"article-title":"Accepted","year":"1980","key":"ref_11","unstructured":"(Accepted 8 October 1980)"},{"article-title":"Medical journal","year":"1880","key":"ref_12","unstructured":"Medical journal, 1880.)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6252.1379","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6252.1379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:21:33Z","timestamp":1765459293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6252.1379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11,22]]},"references-count":12,"journal-issue":{"issue":"6252","published-online":{"date-parts":[[1980,11,22]]},"published-print":{"date-parts":[[1980,11,22]]}},"alternative-id":["10.1136\/bmj.281.6252.1379"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6252.1379","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,11,22]]}}}