{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:29:34Z","timestamp":1765459774291,"version":"3.46.0"},"reference-count":31,"publisher":"BMJ","issue":"6253","license":[{"start":{"date-parts":[[1980,11,29]],"date-time":"1980-11-29T00:00:00Z","timestamp":344304000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J"],"published-print":{"date-parts":[[1980,11,29]]},"abstract":"<jats:p>High serum follicle stimulating hormone (FSH) values are consistent with ovarian failure. We studied the progress of 67 women aged under 35 years with oligomenorrhoea or secondary amenorrhoea in whom the serum FSH value was greater than 20 U\/1. Twenty-four patients remained amenorrhoeic, but 17 ovulated and six conceived, two on two occasions. Coincident mean serum luteinising hormone (LH) concentrations were significantly lower and mean total urinary oestrogen concentrations were significantly higher in patients who subsequently ovulated, but the degree of increase in FSH did not correlate well with later ovarian function. Treatment with oestrogens, clomiphene citrate, human pituitary gonadotrophin, and bromocriptine was of no benefit in inducing an ovarian response while FSH concentrations remained raised. Our results suggest that a considerable proportion of younger women with ovulatory disorders associated with FSH values in the menopausal range will spontaneously resume ovulation and some will conceive.<\/jats:p>","DOI":"10.1136\/bmj.281.6253.1447","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T18:32:30Z","timestamp":1238697150000},"page":"1447.1-1450","source":"Crossref","is-referenced-by-count":49,"title":["The significance of FSH elevation in young women with disorders of ovulation."],"prefix":"10.1136","volume":"281","author":[{"given":"C","family":"O'Herlihy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Pepperell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J H","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1980,11,29]]},"reference":[{"key":"ref_1","first-page":"1","article-title":"Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles","volume":"26","author":"Ross, G.T.; Cargille, C.M.; Lipsett, M.B.","year":"1970","unstructured":"Ross GT, Cargille CM, Lipsett MB, et al. Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Recent Prog Horm Res 1970;26:1-62.","journal-title":"Recent Prog Horm Res"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1210\/jcem-36-6-1205","article-title":"Further studies ofgonadotrophin and estradiol secretion during the preovulatory phase of the human menstrual cycle","volume":"36","author":"Korenman, S.; Sherman, B.M.","year":"1973","unstructured":"Korenman S, Sherman BM. Further studies ofgonadotrophin and estradiol secretion during the preovulatory phase of the human menstrual cycle. Jf Clin Endocrinol Metab 1973;36:1205-9.","journal-title":"Jf Clin Endocrinol Metab"},{"key":"ref_3","first-page":"68","article-title":"Plasma gonadotrophin levels in ovulatory and anovulatory patients. Br J'","volume":"83","author":"Pepperell, R.J.; Burger, H.G.; De Kretser, D.M.; Rennie, G.C.","year":"1976","unstructured":"Pepperell RJ, Burger HG, De Kretser DM, Rennie GC. 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Singapore: Endocrine and Metabolic Society of","first-page":"389","article-title":"Clinical investigation and assessment of amenorrhoea","author":"Pepperell, R.J.","year":"1978","unstructured":"Pepperell RJ. Clinical investigation and assessment of amenorrhoea. Proceedings of 6th Asia Oceania Congress in Endocrinology. Singapore: Endocrine and Metabolic Society of Singapore, 1978:389-92."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0002-9378(16)34255-7","article-title":"A new syndrome of amenorrhoea in association with hyper-gonadotrophism and apparently normal ovarian follicular apparatus","volume":"104","author":"Jones, G.S.; De Moraes-Ruehsen, M.","year":"1969","unstructured":"Jones GS, De Moraes-Ruehsen M. A new syndrome of amenorrhoea in association with hyper-gonadotrophism and apparently normal ovarian follicular apparatus. 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Hormonal characteristics of the human menstrual cycle throughout reproductive life. J Clin Invest 1975;55: 699-706.","journal-title":"J Clin Invest"},{"key":"ref_28","first-page":"557","article-title":"Pituitary ovarian relationships preceding the menopause. AmJ7 Obstet Gynecol","volume":"129","author":"Reyes, F.I.; Winter, J.S.; Faiman, C.","year":"1977","unstructured":"Reyes FI, Winter JS, Faiman C. Pituitary ovarian relationships preceding the menopause. AmJ7 Obstet Gynecol 1977;129:557-64."},{"key":"ref_29","first-page":"477","article-title":"Anonymous: Have I stopped ovulating yet?","volume":"i:","year":"1979","unstructured":"Anonymous: Have I stopped ovulating yet? Lancet 1979;i:477-8.","journal-title":"Lancet"},{"article-title":"Accepted","year":"1980","key":"ref_30","unstructured":"(Accepted 13 October 1980)"},{"key":"ref_31","article-title":"general practitioners and trainees practising in the City of Southampton were sent a letter explaining the purpose of the study and asking them to participate. This was followed within a few days by a telephone call to the surgery to arrange an interview. All interviews were conducted by SN between January and","volume-title":"The semi-structured questionnaire* contained items about breast disease including the clinical management, cancer survival rates and risk factors, breast self-examination and other screening methods, and health education","author":"All 112 NHS","year":"1980","unstructured":"All 112 NHS general practitioners and trainees practising in the City of Southampton were sent a letter explaining the purpose of the study and asking them to participate. This was followed within a few days by a telephone call to the surgery to arrange an interview. All interviews were conducted by SN between January and March 1980. The semi-structured questionnaire* contained items about breast disease including the clinical management, cancer survival rates and risk factors, breast self-examination and other screening methods, and health education."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.281.6253.1447","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.281.6253.1447","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T13:26:13Z","timestamp":1765459573000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.281.6253.1447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1980,11,29]]},"references-count":31,"journal-issue":{"issue":"6253","published-online":{"date-parts":[[1980,11,29]]},"published-print":{"date-parts":[[1980,11,29]]}},"alternative-id":["10.1136\/bmj.281.6253.1447"],"URL":"https:\/\/doi.org\/10.1136\/bmj.281.6253.1447","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1980,11,29]]}}}