{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T09:42:27Z","timestamp":1768470147714,"version":"3.49.0"},"reference-count":14,"publisher":"BMJ","issue":"6257","license":[{"start":{"date-parts":[[1981,1,3]],"date-time":"1981-01-03T00:00:00Z","timestamp":347328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1981,1,3]]},"abstract":"<jats:p>Benign intracranial hypertension occurred in four young women taking tetracycline for acne; two were also taking vitamin A. In a fifth case a 14-year-old boy developed papilloedema after taking a short course of tetracycline for bronchitis. All symptoms disappeared soon after stopping the drugs, though in two cases the papilloedema persisted for many months. Benign intracranial hypertension should be sought in any young woman complaining of headache during treatment with tetracycline. Moreover, young women given vitamin A and tetracycline in combination for acne may be at special risk and should be kept under surveillance.<\/jats:p>","DOI":"10.1136\/bmj.282.6257.19","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"19-20","source":"Crossref","is-referenced-by-count":65,"title":["Tetracycline and benign intracranial hypertension: report of five cases."],"prefix":"10.1136","volume":"282","author":[{"given":"B N","family":"Walters","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Gubbay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1981,1,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0022-3476(61)80061-9","article-title":"Bulging fontanelle: a complication of tetracycline therapy in infants","volume":"58","author":"Fields, J.P.","year":"1961","unstructured":"Fields JP. Bulging fontanelle: a complication of tetracycline therapy in infants.J Pediatr 1961;58:74-6.","journal-title":"J Pediatr"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1111\/j.1469-8749.1965.tb07843.x","article-title":"Acute benign intracranial hypertension in an infant receiving tetracycline","volume":"7","author":"O'Doherty, N.J.","year":"1965","unstructured":"O'Doherty NJ. Acute benign intracranial hypertension in an infant receiving tetracycline. Dev Med Child Neurol 1965;7:677-80.","journal-title":"Dev Med Child Neurol"},{"key":"ref_3","first-page":"169","article-title":"Benign intracranial hypertension in qp adult after tetracycline therapy","author":"Koch-Weser, J.; Gilmore, E.B.","year":"1967","unstructured":"Koch-Weser J, Gilmore EB. Benign intracranial hypertension in qp adult after tetracycline therapy.JAMA 1967;200:169-71."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"334","DOI":"10.5694\/j.1326-5377.1977.tb76719.x","article-title":"Papilloedema in an adolescent due to tetracycline","volume":"i:","author":"Ohlrich, G.D.; Ohhrich, J.G.","year":"1977","unstructured":"Ohlrich GD, Ohhrich JG. Papilloedema in an adolescent due to tetracycline. Medj Aust 1977;i:334-5.","journal-title":"Medj Aust"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.5694\/j.1326-5377.1980.tb134884.x","article-title":"Pseudotumor cerebri associated with minocycline therapy for acne","volume":"i:","author":"Beran, R.G.","year":"1980","unstructured":"Beran RG. Pseudotumor cerebri associated with minocycline therapy for acne. 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Brain 1974;97:289-300.","journal-title":"Brain"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/brain\/97.1.301","article-title":"Benign intracranial hypertension: CSF pressure and circulation","volume":"97","author":"Johnston, I.; Paterson, A.","year":"1974","unstructured":"Johnston I, Paterson A. Benign intracranial hypertension: CSF pressure and circulation. Brain 1974;97:301-12.","journal-title":"Brain"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1056\/NEJM197804132981519","article-title":"Indomethacin causing pseudotumor cerebri in Bartter's syndrome","volume":"298","author":"Konomi, H.; Tada, H.","year":"1978","unstructured":"Konomi H, Tada H. Indomethacin causing pseudotumor cerebri in Bartter's syndrome. N EnglJ Med 1978;298:855.","journal-title":"N EnglJ Med"},{"key":"ref_12","first-page":"744","article-title":"Intracranial hypertension in a child during treatment with Nalidixic acid. 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