{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:20:51Z","timestamp":1761675651739},"reference-count":10,"publisher":"BMJ","issue":"6284","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1981,7,11]]},"DOI":"10.1136\/bmj.283.6284.99","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:00:59Z","timestamp":1238684459000},"page":"99-101","source":"Crossref","is-referenced-by-count":38,"title":["Debendox in early pregnancy and fetal malformation."],"prefix":"10.1136","volume":"283","author":[{"given":"D M","family":"Fleming","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D","family":"Knox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Crombie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1136\/bmj.1.6114.691","article-title":"Unusual fetal malformations in early pregnancy","volume":"i:","author":"Donnai, D.; Harris, R.","year":"1978","unstructured":"Donnai D, Harris R. Unusual fetal malformations in early pregnancy. Br MedJ7 1978;i:691-2.","journal-title":"Br MedJ7"},{"key":"ref_2","first-page":"631","article-title":"Birmingham Research Unit of the Royal College of General Practitioners. Morbidity and drugs in pregnancy. Jf R Coll Gen Pract","volume":"25","year":"1975","unstructured":"Birmingham Research Unit of the Royal College of General Practitioners. Morbidity and drugs in pregnancy. Jf R Coll Gen Pract 1975;25:631-45."},{"key":"ref_3","first-page":"117","article-title":"Aspects of prescribing during pregnancy. Proceedings of the Fourth National Congress of the French Perinatal Medical Society","author":"Crombie, D.L.; Fleming, D.M.","year":"1975","unstructured":"Crombie DL, Fleming DM. Aspects of prescribing during pregnancy. Proceedings of the Fourth National Congress of the French Perinatal Medical Society. Paris: Dubois and Renaud Librairie Arnette, 1975: 117-27.","journal-title":"Paris: Dubois and Renaud Librairie Arnette"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1136\/bmj.281.6252.1379","article-title":"Debendox and congenital malformation in Northern Ireland","volume":"281","author":"Harron, D.W.G.; Griffiths, K.; Shanks, R.G.","year":"1980","unstructured":"Harron DWG, Griffiths K, Shanks RG. Debendox and congenital malformation in Northern Ireland. Br MedJa 1980;281:1379-81.","journal-title":"Br MedJa"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/0002-9378(76)90601-3","article-title":"An evaluation of the teratogenicity of certain anti nauseant drugs","volume":"125","author":"Milkovich, L.; Van den Berg, B.J.","year":"1976","unstructured":"Milkovich L, Van den Berg BJ. An evaluation of the teratogenicity of certain anti nauseant drugs. Am J Obstet Gynecol 1976;125:244-8.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/tera.1420170109","article-title":"Teratogenicity testing in humans: a method demonstrating safety of Bendectin","volume":"17","author":"Smithells, R.W.; Sheppard, S.","year":"1978","unstructured":"Smithells RW, Sheppard S. Teratogenicity testing in humans: a method demonstrating safety of Bendectin. Teratology 1978;17:31-5.","journal-title":"Teratology"},{"key":"ref_7","article-title":"Accepted 12","year":"1981","unstructured":"(Accepted 12 May 1981)"},{"key":"ref_8","article-title":"Thirty-eight cases of suspected yersinia arthritis occurring in southern Sweden in 1975-6 were reviewed four to five years later. In 31 cases the diagnosis was confirmed. At follow-up three of the patients had definite ankylosing spondylitis, three radiologically confirmed sacroiliitis, three extensor tenosynovitis, five isolated articular joint disease, and 10 localised arthralgias; one patient had developed seropositive rheumatoid arthritis. Only six of the 31 patients were free of joint symptoms","unstructured":"Thirty-eight cases of suspected yersinia arthritis occurring in southern Sweden in 1975-6 were reviewed four to five years later. In 31 cases the diagnosis was confirmed. At follow-up three of the patients had definite ankylosing spondylitis, three radiologically confirmed sacroiliitis, three extensor tenosynovitis, five isolated articular joint disease, and 10 localised arthralgias; one patient had developed seropositive rheumatoid arthritis. Only six of the 31 patients were free of joint symptoms."},{"key":"ref_9","article-title":"Reactive arthritis after infection with Yersinia enterocolitica is well recognised in some parts of the world,'-9 and the prognosis is generally assumed to be favourable. An association with HLA-B27,10 -14 and evidence of transition into rheumatoid arthritis have been reported,3 4 6 but few systematic long-term follow-up studies have been published. We have therefore studied the outcome in a consecutive group of patients four years after acute yersinia arthritis. A surprisingly high incidence of joint symptoms was encountered","unstructured":"Reactive arthritis after infection with Yersinia enterocolitica is well recognised in some parts of the world,'-9 and the prognosis is generally assumed to be favourable. An association with HLA-B27,10 -14 and evidence of transition into rheumatoid arthritis have been reported,3 4 6 but few systematic long-term follow-up studies have been published. We have therefore studied the outcome in a consecutive group of patients four years after acute yersinia arthritis. A surprisingly high incidence of joint symptoms was encountered."},{"key":"ref_10","article-title":"Patients and methods We reviewed 45 consecutive patients in whom during 1975-6 suspected reactive arthritis had been diagnosed and tests on sera had yielded positive agglutinin titres against Y enterocolitica type 3. Of these patients, 38 were traced and re-examined clinically. X-ray pictures were taken from painful joints. Blood was analysed for haemoglobin concentration, erythrocyte sedimentation rate, liver enzyme activities, and serum creatinine concentration. Urine analysis was performed. In addition, a plasma sample was analysed for concentrations of albumin, fibrinogen, az-antitrypsin, orosomucoid, haptoglobin","unstructured":"Patients and methods We reviewed 45 consecutive patients in whom during 1975-6 suspected reactive arthritis had been diagnosed and tests on sera had yielded positive agglutinin titres against Y enterocolitica type 3. Of these patients, 38 were traced and re-examined clinically. X-ray pictures were taken from painful joints. Blood was analysed for haemoglobin concentration, erythrocyte sedimentation rate, liver enzyme activities, and serum creatinine concentration. Urine analysis was performed. In addition, a plasma sample was analysed for concentrations of albumin, fibrinogen, az-antitrypsin, orosomucoid, haptoglobin, caeruloplasmin, IgG, IgA, IgM, C3, and C4."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.283.6284.99","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T19:03:47Z","timestamp":1601060627000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.283.6284.99"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,7,11]]},"references-count":10,"journal-issue":{"issue":"6284","published-print":{"date-parts":[[1981,7,11]]}},"URL":"https:\/\/doi.org\/10.1136\/bmj.283.6284.99","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,7,11]]}}}