{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T21:13:05Z","timestamp":1778274785990,"version":"3.51.4"},"reference-count":13,"publisher":"BMJ","issue":"6299","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["BMJ"],"published-print":{"date-parts":[[1981,10,24]]},"DOI":"10.1136\/bmj.283.6299.1081","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T15:00:59Z","timestamp":1238684459000},"page":"1081-1083","source":"Crossref","is-referenced-by-count":85,"title":["Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone."],"prefix":"10.1136","volume":"283","author":[{"given":"G","family":"Decaux","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Genette","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/0002-9343(67)90096-4","article-title":"The syndrome of inappropriate secretion of antidiuretic hormone","volume":"42","author":"Bartter, F.C.; Schwartz, W.B.","year":"1967","unstructured":"Bartter FC, Schwartz WB. The syndrome of inappropriate secretion of antidiuretic hormone. Am 7 Med 1967;42:790-806.","journal-title":"Am 7 Med"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1056\/NEJM197801262980401","article-title":"Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone","volume":"298","author":"JN, Jr, Forrest; M, Cox; C, Hong; G, Morrison; M, Bia; I, Singer","year":"1978","unstructured":"Forrest JN Jr, Cox M, Hong C, Morrison G, Bia M, Singer I. Superiority of demeclocycline over lithium in the treatment of chronic syndrome of inappropriate secretion of antidiuretic hormone. 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JAMA 1956;160:943-9.","journal-title":"JAMA"},{"key":"ref_9","article-title":"Accepted 5","year":"1981","unstructured":"(Accepted 5 August 1981)"},{"key":"ref_10","article-title":"The incidence of acute appendicitis was compared among residents in nine towns in England and Wales, the towns having been chosen so that three were in the north, three in the central latitude band, and three in the south. Each group of three towns comprised one with \"better,\" one with \"intermediate,\" and one with \"worse\" socioeconomic conditions. The data were derived from hospital records for the years 1974-7. Hospital discharge rates for acute appendicitis were higher in the three northern towns in both sexes","volume-title":"There was no consistent variation with the socioeconomic state of the towns","author":"and all age groups","unstructured":"The incidence of acute appendicitis was compared among residents in nine towns in England and Wales, the towns having been chosen so that three were in the north, three in the central latitude band, and three in the south. Each group of three towns comprised one with \"better,\" one with \"intermediate,\" and one with \"worse\" socioeconomic conditions. The data were derived from hospital records for the years 1974-7. Hospital discharge rates for acute appendicitis were higher in the three northern towns in both sexes and all age groups. There was no consistent variation with the socioeconomic state of the towns."},{"key":"ref_11","article-title":"Hospital Activity Analysis (HAA) data were obtained for each county borough from the regional health authorities. These data comprised tabulations of the numbers of patients resident in the county boroughs who had (1) been discharged from a hospital within the region during the period from 1 January 1974 to 31 December","unstructured":"Hospital Activity Analysis (HAA) data were obtained for each county borough from the regional health authorities. These data comprised tabulations of the numbers of patients resident in the county boroughs who had (1) been discharged from a hospital within the region during the period from 1 January 1974 to 31 December"},{"key":"ref_12","article-title":"been diagnosed as having acute appendicitis (ICD numbers 540, 541, eighth revision)","volume-title":"been admitted as emergencies, and (4) undergone appendicectomy (OPCS numbers 441, 444). Use of these criteria was intended to exclude patients with non-acute appendicitis","year":"(3)","unstructured":", (2) been diagnosed as having acute appendicitis (ICD numbers 540, 541, eighth revision), (3) been admitted as emergencies, and (4) undergone appendicectomy (OPCS numbers 441, 444). Use of these criteria was intended to exclude patients with non-acute appendicitis."},{"key":"ref_13","article-title":"Therefore, variations between the towns in the incidence of acute appendicitis, as calculated from HAA data, might reflect different HAA coding practices or surgical policies rather than true variations in incidence. For this reason it was necessary to correct the data by determining the proportion of removed appendices that were actually inflamed. Each town was visited and the pathology reports on appendicectomy specimens received during one year were inspected. In eight towns the year chosen was 1976; in the other town the records for 1977 were more complete than those for 1976 and were used instead. The appendices were classified into two groups according to the histology reports-namely, \"inflamed,\" if polymorphonuclear leucocytes had been seen in the muscular layer of the appendicular wall, and \"normal.\" The few equivocal reports were assessed by a consultant pathologist in Southampton","unstructured":"Therefore, variations between the towns in the incidence of acute appendicitis, as calculated from HAA data, might reflect different HAA coding practices or surgical policies rather than true variations in incidence. For this reason it was necessary to correct the data by determining the proportion of removed appendices that were actually inflamed. Each town was visited and the pathology reports on appendicectomy specimens received during one year were inspected. In eight towns the year chosen was 1976; in the other town the records for 1977 were more complete than those for 1976 and were used instead. The appendices were classified into two groups according to the histology reports-namely, \"inflamed,\" if polymorphonuclear leucocytes had been seen in the muscular layer of the appendicular wall, and \"normal.\" The few equivocal reports were assessed by a consultant pathologist in Southampton."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.283.6299.1081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T19:08:54Z","timestamp":1601060934000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.283.6299.1081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10,24]]},"references-count":13,"journal-issue":{"issue":"6299","published-print":{"date-parts":[[1981,10,24]]}},"URL":"https:\/\/doi.org\/10.1136\/bmj.283.6299.1081","relation":{},"ISSN":["0959-8138","1468-5833"],"issn-type":[{"value":"0959-8138","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,10,24]]}}}