{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:31:44Z","timestamp":1765305104766,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6343","license":[{"start":{"date-parts":[[1982,9,11]],"date-time":"1982-09-11T00:00:00Z","timestamp":400550400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,9,11]]},"abstract":"<jats:p>A patient with renal failure and insulin-dependent diabetes received renal and segmental pancreatic allografts from the same donor, with exocrine drainage of the pancreas being directed into the bowel. An attempt was made to maintain the serum concentrations of cyclosporin A between 300 and 1000 \u03bcg\/l to avoid serious nephrotoxicity and rejection. Considerable difficulty was experienced in controlling the serum concentrations even with continuous intravenous infusion. When the concentrations were maintained between 300 and 1000 \u03bcg\/l function in both allografts was satisfactory.<\/jats:p>\n                  <jats:p>At seven months the patient required no insulin and had good renal function. He was not receiving corticosteroids.<\/jats:p>","DOI":"10.1136\/bmj.285.6343.677","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"677-680","source":"Crossref","is-referenced-by-count":11,"title":["Renal and segmental pancreatic grafting with draining of exocrine secretion and initial continuous intravenous cyclosporin A in a patient with insulin-dependent diabetes and renal failure"],"prefix":"10.1136","volume":"285","author":[{"given":"R Y","family":"Calne","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J G","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Rolles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T J","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T","family":"Kass","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,9,11]]},"reference":[{"key":"ref_1","first-page":"633","article-title":"A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man","volume":"84","author":"Dubernard, J.M.; Traeger, J.; Neyra, P.; Touraine, J.L.; Tranchant, D.; Blanc-Brunat, N.","year":"1978","unstructured":"Dubernard JM, Traeger J, Neyra P, Touraine JL, Tranchant D, Blanc-Brunat N. A new method of preparation of segmental pancreatic grafts for transplantation: trials in dogs and in man. Surgery 1978;84: 633-9.","journal-title":"Surgery"},{"key":"ref_2","first-page":"11","volume":"285","author":"MEDICAL, B.R.I.T.I.S.H.","year":"1982","unstructured":"BRITISH MEDICAL JOURNAL VOLUME 285 11 SEPTEMBER 1982","journal-title":"JOURNAL VOLUME"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0140-6736(79)92440-1","article-title":"Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases and 2 livers","volume":"ii:","author":"Calne, R.Y.; Rolles, K.; White, D.J.G.","year":"1979","unstructured":"Calne RY, Rolles K, White DJG, et al. Cyclosporin A initially as the only immunosuppressant in 34 recipients of cadaveric organs: 32 kidneys, 2 pancreases and 2 livers. Lancet 1979;ii:1033-6.","journal-title":"Lancet"},{"key":"ref_4","first-page":"349","volume-title":"Cyclosporin A in clinical organ grafting. Transplant Proc 1981; 13","author":"Calne, R.Y.; Rolles, K.; White, D.J.G.","unstructured":"Calne RY, Rolles K, White DJG, et al. Cyclosporin A in clinical organ grafting. Transplant Proc 1981;13:349-58."},{"key":"ref_5","series-title":"Proceedings of international symposium on cyclosporin A","first-page":"453","article-title":"Combined renal and pancreas transplantation with cyclosporin","author":"In, A.","year":"1982","unstructured":"McMaster P, Buckes J, Gibby 0, et al. Combined renal and pancreas transplantation with cyclosporin A. In: White DJG, ed. Proceedings of international symposium on cyclosporin A. Amsterdam: Elsevier, 1982: 453."},{"issue":"2","key":"ref_6","first-page":"5","article-title":"Pancreas and Islet Transplant Registry report","volume":"2","author":"Sutherland, D.E.R.","year":"1981","unstructured":"Sutherland DER. Pancreas and Islet Transplant Registry report: July 1981. Transplantation Topics 1981;2(2):5-8.","journal-title":"Transplantation Topics"},{"issue":"29","key":"ref_7","article-title":"Segmental pancreatic transplantation with duct ligation or drainage to a jejunal Roux-en-Y loop in non-uraemic diabetic patients","volume":"1980","author":"Groth, C.G.; Lundgren, G.; Gunnarsson, R.; Amer, P.; Berg, B.; Ostman, J.","unstructured":"Groth CG, Lundgren G, Gunnarsson R, Amer P, Berg B, Ostman J. Segmental pancreatic transplantation with duct ligation or drainage to a jejunal Roux-en-Y loop in non-uraemic diabetic patients. Diabetes 1980:29, suppl 1:3.","journal-title":"Diabetes"},{"issue":"2","key":"ref_8","first-page":"51","article-title":"Technical observations in segmental pancreas allografting: observations on pancreatic","volume-title":"blood flow. Transplant Proc 1980","volume":"12","author":"Calne, R.Y.; McMaster, P.; Rolles, K.; Duffy, T.J.","unstructured":"Calne RY, McMaster P, Rolles K, Duffy TJ. Technical observations in segmental pancreas allografting: observations on pancreatic blood flow. Transplant Proc 1980;12, suppl 2:51-7."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/S0140-6736(81)91971-1","article-title":"Immunological and pharmacologi-cal monitoring in the clinical use of cyclosporin A","volume":"i:","author":"Keown, P.A.; Stiller, C.R.; Ulan, R.A.","year":"1981","unstructured":"Keown PA, Stiller CR, Ulan RA, et al. Immunological and pharmacologi-cal monitoring in the clinical use of cyclosporin A. Lancet 1981;i: 686-9.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0140-6736(81)91142-9","article-title":"Nephrotoxicity of cyclosporin A","volume":"ii:","author":"Hows, J.M.; Gordon-Smith, E.C.","year":"1981","unstructured":"Hows JM, Gordon-Smith EC. Nephrotoxicity of cyclosporin A. Lancet 1981;ii:876-7.","journal-title":"Lancet"},{"year":"1982","unstructured":"(Accepted 28 June 1982)","article-title":"Accepted 28","key":"ref_11"},{"unstructured":"We examined the clinical course of operable breast cancer and looked at what effect tumour size had on the probability of death from the disease. We analysed data from 1936 patients who were classified as having international stage I and II disease: decision theory was used to show a technique for determining the best strategy for adjuvant chemotherapy in the overall management of breast cancer.","article-title":"We examined the clinical course of operable breast cancer and looked at what effect tumour size had on the probability of death from the disease. We analysed data from 1936 patients who were classified as having international stage I and II disease: decision theory was used to show a technique for determining the best strategy for adjuvant chemotherapy in the overall management of breast cancer","key":"ref_12"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.285.6343.677","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.285.6343.677","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:28:49Z","timestamp":1765304929000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.285.6343.677"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,11]]},"references-count":12,"journal-issue":{"issue":"6343","published-online":{"date-parts":[[1982,9,11]]},"published-print":{"date-parts":[[1982,9,11]]}},"alternative-id":["10.1136\/bmj.285.6343.677"],"URL":"https:\/\/doi.org\/10.1136\/bmj.285.6343.677","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1982,9,11]]}}}