{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:47:34Z","timestamp":1765306054034,"version":"3.46.0"},"reference-count":7,"publisher":"BMJ","issue":"6345","license":[{"start":{"date-parts":[[1982,9,25]],"date-time":"1982-09-25T00:00:00Z","timestamp":401760000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,9,25]]},"abstract":"<jats:p>Pyoderma gangrenosum is most commonly associated with inflammatory bowel disease and rheumatoid arthritis, but it has been associated with various haematological malignancies. A 54-year-old man with no history of bowel disease or arthritis presented with a leg ulcer, which healed after treatment. Results of bone marrow aspiration were compatible with primary thrombocythaemia. Seven weeks later there were pronounced recurrence of the ulceration and pyoderma gangrenosum was diagnosed. The appearance of pyoderma gangrenosum associated with blood disorders may differ from that associated with bowel and joint disease.<\/jats:p>","DOI":"10.1136\/bmj.285.6345.837","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"837-838","source":"Crossref","is-referenced-by-count":11,"title":["Pyoderma gangrenosum associated with primary thrombocythaemia."],"prefix":"10.1136","volume":"285","author":[{"given":"P","family":"Shepherd","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Liddell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,9,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1001\/archderm.1972.01620150083026","article-title":"Bullous pyoderma gangrenosum and leukaemia","volume":"106","author":"Perry, H.O.; Winkelmann, R.K.","year":"1972","unstructured":"Perry HO, Winkelmann RK. Bullous pyoderma gangrenosum and leukaemia. Arch Dermatol 1972;106:901-5.","journal-title":"Arch Dermatol"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1001\/archinte.1979.03630450074024","article-title":"Pyoderma gangrenosum and myeloproliferative disorders","volume":"139","author":"Romane, J.","year":"1979","unstructured":"Romane J. Pyoderma gangrenosum and myeloproliferative disorders. Arch Intern Med 1979;139:932-4.","journal-title":"Arch Intern Med"},{"key":"ref_3","first-page":"548","article-title":"Pyoderma gangrenosum with myelofibrosis","volume":"72","author":"Gopinath, D.K.; Wolfe, R.D.; Sabharwal, K.","year":"1974","unstructured":"Gopinath DK, Wolfe RD, Sabharwal K. Pyoderma gangrenosum with myelofibrosis. J Ky Med Assoc 1974;72:548-50,566.","journal-title":"J Ky Med Assoc"},{"key":"ref_4","first-page":"260","article-title":"Pyoderma gangrenosum. Un cas de polycythaemie vraie. Bulletin de la Societe Franfaise de Dermatologie","volume":"78","author":"Feuerman, E.; Potruch-Eisenkraft, S.","year":"1971","unstructured":"Feuerman E, Potruch-Eisenkraft S. Pyoderma gangrenosum. Un cas de polycythaemie vraie. Bulletin de la Societe Franfaise de Dermatologie et de Syphiligraphie 1971;78:260-1.","journal-title":"et de Syphiligraphie"},{"key":"ref_5","first-page":"251","article-title":"The problem of pyoderma gangrenosum","volume":"80","author":"Feuerman, E.; Potruch-Eisenkraft, S.","year":"1971","unstructured":"Feuerman E, Potruch-Eisenkraft S. The problem of pyoderma gangrenosum. Harefuah 1971;80:251-4.","journal-title":"Harefuah"},{"article-title":"Accepted","year":"1982","key":"ref_6","unstructured":"(Accepted 14 July 1982)"},{"key":"ref_7","unstructured":"P JERNTORP, MD, registrar B BERGSTROM, MD, registrar L-O ALMER, MD, lecturer of type II diabetes (non-insulin-dependent or maturity-onset diabetes). The implications of the flush were not known until 1978, however, when Leslie and Pyke2 reported that chlorpropamide-alcohol flushing was inherited as an autosomally dominant trait in type II diabetes. This was followed by reports of a lower prevalence ofdiabetic retinopathy,3 large-vessel disease,4 5 peripheral neuropathy,5 and diabetic nephropathy6 in the flushers than in the non-flushers. The prevalence of chlorpropamide-alcohol flushing in type II diabetes has varied considerably at around 30%.-","article-title":"lecturer of type II diabetes (non-insulin-dependent or maturity-onset diabetes). The implications of the flush were not known until 1978, however, when Leslie and Pyke2 reported that chlorpropamide-alcohol flushing was inherited as an autosomally dominant trait in type II diabetes. This was followed by reports of a lower prevalence ofdiabetic retinopathy,3 large-vessel disease,4 5 peripheral neuropathy,5 and diabetic nephropathy6 in the flushers than in the non-flushers. The prevalence of chlorpropamide-alcohol flushing in type II diabetes has varied considerably at around 30%.-"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.285.6345.837","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.285.6345.837","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T18:41:37Z","timestamp":1765305697000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.285.6345.837"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,9,25]]},"references-count":7,"journal-issue":{"issue":"6345","published-online":{"date-parts":[[1982,9,25]]},"published-print":{"date-parts":[[1982,9,25]]}},"alternative-id":["10.1136\/bmj.285.6345.837"],"URL":"https:\/\/doi.org\/10.1136\/bmj.285.6345.837","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1982,9,25]]}}}