{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T19:00:33Z","timestamp":1765306833464,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6348","license":[{"start":{"date-parts":[[1982,10,16]],"date-time":"1982-10-16T00:00:00Z","timestamp":403574400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,10,16]]},"abstract":"<jats:p>Sixteen young women with hyperprolactinaemia and normal or equivocal sella in radiographs underwent computed tomography using a Siemens Somatom II. In all but one case an abnormality was found. The sella was full in seven and partially empty in nine. A tumour was visible in six of the full and in four of the partially empty sellae. All but one of the 10 tumours was unilateral, and in seven the pituitary stalk was deviated away from the tumour. After administration of intravenous contrast (Urografin) four tumours showed diffuse enhancement, four ring enhancement, and two enhanced less than adjacent normal pituitary tissue. Two of the tumours have been subsequently shown histologically to be prolactinomas. Prolactin response to thyrotrophin-releasing hormone predicted a tumour in seven out of eight with visible tumours but also in three out of four without visible tumours; using metoclopramide, a tumour was predicted in six out of seven with tumours, but again in three out of four without visible tumours. Such results question the value of dynamic tests for the discrimination of tumours. We conclude that practically all women with sustained hyperprolactinaemia and a normal or equivocal sella radiologically have pituitary disease.<\/jats:p>","DOI":"10.1136\/bmj.285.6348.1078","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1078-1081","source":"Crossref","is-referenced-by-count":13,"title":["CT abnormalities of the pituitary in hyperprolactinaemic women with normal or equivocal sellae radiologically."],"prefix":"10.1136","volume":"285","author":[{"given":"R T","family":"Jung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"White","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N B","family":"Bowley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Bydder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Mashiter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Joplin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,10,16]]},"reference":[{"key":"ref_1","first-page":"363","article-title":"Outcome of pregnancy in women with pituitary adenoma","volume-title":"Fertil Steril","volume":"31","author":"Gemzell, C.; Wang, C.F.","year":"1979","unstructured":"Gemzell C, Wang CF. Outcome of pregnancy in women with pituitary adenoma. Fertil Steril 1979;31:363-72."},{"key":"ref_2","first-page":"103","article-title":"Pituitary tumours and pregnancy","volume-title":"adenomas: biology, physiopathology and treatment","author":"Nillius, S.J.; Bergh, T.; Larson, S.G.","year":"1980","unstructured":"Nillius SJ, Bergh T, Larson SG. Pituitary tumours and pregnancy. In: Derome PJ, Jedynak CP, Peilon F, eds. Pituitary adenomas: biology, physiopathology and treatment. France: Asclepios, 1980:103-11."},{"key":"ref_3","first-page":"179","article-title":"Microadenomas and CT scan","volume-title":"adenomas: biology, physiopathology and treatment","author":"Bamberger-Bozo, C.H.","year":"1980","unstructured":"Bamberger-Bozo CH. Microadenomas and CT scan. In: Derome PJ, Jedynak CP, Peilon F, eds. Pituitary adenomas: biology, physiopathology and treatment. France: Asclepios, 1980:179-88."},{"key":"ref_4","first-page":"820","article-title":"The pituitary fossa in Cushing's syndrome; a retrospective analysis of 93 patients. BrJ'","volume":"49","author":"MacErlean, D.P.; Doyle, F.H.","year":"1976","unstructured":"MacErlean DP, Doyle FH. The pituitary fossa in Cushing's syndrome; a retrospective analysis of 93 patients. BrJ' Radiol 1976;49:820-6.","journal-title":"Radiol"},{"key":"ref_5","first-page":"326","article-title":"Combined test for assessment of anterior pituitary function","volume":"iv:","author":"Harsoulis, P.; Marshall, J.C.; Kuku, S.F.; Burke, C.W.; London, D.R.; Fraser, T.R.","year":"1973","unstructured":"Harsoulis P, Marshall JC, Kuku SF, Burke CW, London DR, Fraser TR. Combined test for assessment of anterior pituitary function. Br Med J 1973;iv:326-9.","journal-title":"Br Med J"},{"key":"ref_6","first-page":"473","article-title":"Treatment of prolactin-secreting pituitary tumours in young women by needle implantation of radioactive yttrium","volume":"47","author":"Kelly, W.F.; Mashiter, K.; Doyle, F.H.; Banks, L.M.; Joplin, G.F.","year":"1978","unstructured":"Kelly WF, Mashiter K, Doyle FH, Banks LM, Joplin GF. Treatment of prolactin-secreting pituitary tumours in young women by needle implantation of radioactive yttrium. Q 7 Med 1978;47:473-93."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1097\/00004728-198010000-00003","article-title":"Computed tomography for diagnosis of empty sella associated with enhancing pituitary microadenoma","volume":"4","author":"Smaltino, F.; Bernini, F.P.; Muras, I.","year":"1980","unstructured":"Smaltino F, Bernini FP, Muras I. Computed tomography for diagnosis of empty sella associated with enhancing pituitary microadenoma. J Comput Ass Tomogr 1980;4:592-9.","journal-title":"J Comput Ass Tomogr"},{"article-title":"Accepted","year":"1982","key":"ref_8","unstructured":"(Accepted 11 August 1982)"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1288\/00005537-196001000-00008","article-title":"How effectively can the laryngectomee speak ?","volume":"70","author":"Snidecor, J.C.; Curry, E.T.","year":"1960","unstructured":"Snidecor JC, Curry ET. How effectively can the laryngectomee speak ? Laryngoscope 1960;70:62-7.","journal-title":"Laryngoscope"},{"key":"ref_10","unstructured":"Type of operation.","article-title":"Type of operation"},{"key":"ref_11","unstructured":"Site of pseudoglottis.","article-title":"Site of pseudoglottis"},{"key":"ref_12","first-page":"961","article-title":"Co-ordination of speech with respiration. Laryngoscope 1956; 66","volume":"3","author":"Simpson, I.C.; Smith, J.C.S.; Gordon, M.T.","year":"1972","unstructured":"Co-ordination of speech with respiration. Laryngoscope 1956;66:173-86,382-401,481-99. 3 Simpson IC, Smith JCS, Gordon MT. Laryngectomy: the influence of muscle reconstruction on the mechanism of oesophageal voice production. 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