{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T03:40:58Z","timestamp":1778298058597,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"6355","license":[{"start":{"date-parts":[[1982,12,4]],"date-time":"1982-12-04T00:00:00Z","timestamp":407808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,12,4]]},"abstract":"<jats:p>Six patients with severe watery diarrhoea were found to have microscopic total colitis. None had any abnormality detectable by conventional tests used to diagnose inflammatory bowel disease-namely, barium radiology and endoscopy. The diagnosis could only be made by microscopic examination of biopsy specimens from the apparently normal colon. Anaemia, raised erythrocyte sedimentation rate, hypokalaemia, and hypoalbuminaemia were common findings. Small-bowel function was normal in all, though three patients had jejunal lesions of uncertain relevance but seemingly unrelated to the diarrhoea. The five patients given anti-inflammatory drugs showed a satisfactory response with improvement of the diarrhoea and colonic inflammation and return to normal of the abnormal laboratory findings. Microscopic colitis is responsible for a proportion of cases of intractable diarrhoea of obscure origin and rectal and colonic biopsies sould be undertaken in such cases.<\/jats:p>","DOI":"10.1136\/bmj.285.6355.1601","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1601-1604","source":"Crossref","is-referenced-by-count":113,"title":["Microscopic colitis-a cause of chronic watery diarrhoea."],"prefix":"10.1136","volume":"285","author":[{"given":"J G","family":"Kingham","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D A","family":"Levison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Ball","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A M","family":"Dawson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,12,4]]},"reference":[{"issue":"1","key":"ref_1","first-page":"87","article-title":"\"Collagenous colitis\" with watery diarrhoea-a new entity?","volume":"1","author":"ILindstrom, C.G.","year":"1976","unstructured":"ILindstrom CG. \"Collagenous colitis\" with watery diarrhoea-a new entity? 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Gut 1969;10:267-9.","journal-title":"Gut"},{"key":"ref_8","first-page":"293","article-title":"Histological and histochemical changes in the jejunal mucosa in ulcerative colitis","volume":"9","author":"Binder, V.; Soltoft, J.; Gudmond-Hoyer, E.","year":"1974","unstructured":"Binder V, Soltoft J, Gudmond-Hoyer E. Histological and histochemical changes in the jejunal mucosa in ulcerative colitis. ScandJ7 Gastroenterol 1974;9:293-7."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0016-5085(80)90575-2","article-title":"Chronic diarrhoea of unknown origin","volume":"78","author":"Ana, C.A.; Morawski, S.G.; Fordtran, J.S.","year":"1980","unstructured":"Read NW, Krejs GJ, Read MG, Santa Ana CA, Morawski SG, Fordtran JS. Chronic diarrhoea of unknown origin. 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