{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T19:35:25Z","timestamp":1765308925263,"version":"3.46.0"},"reference-count":11,"publisher":"BMJ","issue":"6355","license":[{"start":{"date-parts":[[1982,12,4]],"date-time":"1982-12-04T00:00:00Z","timestamp":407808000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,12,4]]},"abstract":"<jats:p>A previously undescribed anaphylactoid reaction to haemodialysis, haemofiltration, or membrane plasma separation occurred in 15 patients receiving regular dialysis. The illness varied in severity from urticaria, sneezing, and watering of the eyes to severe bronchospasm and cardiovascular collapse, and began within a minute of blood being returned from the dialyser or filtration device to the patient. Reactions developed only when a dialyser sterilised with ethylene oxide was used for the first time and never after sterilisation with formalin. Several patients had more than one reaction while three had a reaction each time a new dialyser was used. Incorrect priming of the dialysers may be a partial explanation of these attacks, but the exact reason for their occurrence is unknown. This is a dramatic and potentially life-threatening syndrome that may not previously have been recognised as a reaction to dialysis.<\/jats:p>","DOI":"10.1136\/bmj.285.6355.1607","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1607-1609","source":"Crossref","is-referenced-by-count":56,"title":["Anaphylactoid reactions due to haemodialysis, haemofiltration, or membrane plasma separation."],"prefix":"10.1136","volume":"285","author":[{"given":"A J","family":"Nicholls","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M M","family":"Platts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,12,4]]},"reference":[{"key":"ref_1","first-page":"251","article-title":"Haemodialysistriggered asthma","volume":"7","author":"Aliama, P.; Brown, P.; Turner, P.; Ward, M.K.; Kerr, D.N.S.","year":"1978","unstructured":"Aliama P, Brown P, Turner P, Ward MK, Kerr DNS. Haemodialysistriggered asthma. Br Med 7 1978;ii:251-2.","journal-title":"Br Med"},{"key":"ref_2","first-page":"247","article-title":"Hemodialysis-associated asthma in a renal failure patient","volume":"25","author":"Hanai, K.E.I.; Horinchi, T.; Hanai, J.","year":"1979","unstructured":"Hanai KEI, Horinchi T, Hanai J, et al. Hemodialysis-associated asthma in a renal failure patient. Nephron 1979;25:247-8.","journal-title":"Nephron"},{"key":"ref_3","first-page":"879","article-title":"Hemodialysis leukopenia","volume":"59","author":"Craddock, P.R.; Fehr, J.; Dalmasso, A.P.; Brigham, K.L.; Jacob, H.S.","year":"1979","unstructured":"Craddock PR, Fehr J, Dalmasso AP, Brigham KL, Jacob HS. Hemodialysis leukopenia. J Clin Invest 1979;59:879-88.","journal-title":"J Clin Invest"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1136\/bmj.1.5748.528","article-title":"Pyrexial reactions during haemodialysis","volume":"i:","author":"Robinson, P.J.A.; Rosen, S.M.","year":"1971","unstructured":"Robinson PJA, Rosen SM. Pyrexial reactions during haemodialysis. Br Med J 1971;i:528-30.","journal-title":"Br Med J"},{"key":"ref_5","first-page":"102","article-title":"Histamine in health and disease","volume":"68","author":"Neugebauer, E.; Lorenz, W.","year":"1981","unstructured":"Neugebauer E, Lorenz W. Histamine in health and disease. Behringer Institute Mitteilungen 1981;68:102-33.","journal-title":"Behringer Institute Mitteilungen"},{"key":"ref_6","first-page":"155","article-title":"Bacterial endotoxin in new and reused hemodialysers: a potential cause of endotoxemia","volume":"27","author":"Petersen, N.J.; Carson, L.A.; Favero, M.S.","year":"1981","unstructured":"Petersen NJ, Carson LA, Favero MS. Bacterial endotoxin in new and reused hemodialysers: a potential cause of endotoxemia. Trans Am Soc Artif Intern Organs 1981;27:155-9.","journal-title":"Trans Am Soc Artif Intern Organs"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.7326\/0003-4819-82-1-58","article-title":"Anaphylaxis from the product(s) of ethylene oxide gas","volume":"82","author":"Poothullil, J.; Shimizu, A.; Day, R.P.; Dolovich, J.","year":"1975","unstructured":"Poothullil J, Shimizu A, Day RP, Dolovich J. Anaphylaxis from the product(s) of ethylene oxide gas. Ann Intern Med 1975;82:58-60.","journal-title":"Ann Intern Med"},{"article-title":"Accepted 28","year":"1982","key":"ref_8","unstructured":"(Accepted 28 October 1982)"},{"key":"ref_9","unstructured":"Radiological and biochemical investigations of renal function were performed in 57 patients with haemophilia, 27 of whom had been previously investigated in 1969. Although one-third of patients had a renal radiographic abnormality, only two had abnormalities persisting since 1969 and attributable to renal bleeding. Isotope renography was a sensitive indicator of renal abnormality whereas a history of haematuria was a poor discriminator for patients with abnormal intravenous urograms or impaired creatinine clearance. Haematuria was not associated with progressive loss of renal function and its natural history in haemophilia is probably benign.","article-title":"Radiological and biochemical investigations of renal function were performed in 57 patients with haemophilia, 27 of whom had been previously investigated in 1969. Although one-third of patients had a renal radiographic abnormality, only two had abnormalities persisting since 1969 and attributable to renal bleeding. Isotope renography was a sensitive indicator of renal abnormality whereas a history of haematuria was a poor discriminator for patients with abnormal intravenous urograms or impaired creatinine clearance. Haematuria was not associated with progressive loss of renal function and its natural history in haemophilia is probably benign"},{"key":"ref_10","unstructured":"In 1969 our two haemophilia centres (Glasgow and Birmingham) separately investigated2 3 two groups of patients with haemophilia with radiographic renal abnormalities (incidences of 38% and 36% respectively). It is clearly important to know whether these abnormalities were transient and of no long-term clinical importance or whether progressive renal damage has subsequently occurred. Renal function was therefore reassessed biochemically and radiologically in 27 patients from the two centres 11 years after the initial investigations. In addition, we have investigated a new series of 30 haemophiliacs adequately treated on demand or by self-therapy for at least five years to determine if the incidence of renal abnormalities has decreased as a consequence of more active treatment.","article-title":"In 1969 our two haemophilia centres (Glasgow and Birmingham) separately investigated2 3 two groups of patients with haemophilia with radiographic renal abnormalities (incidences of 38% and 36% respectively). It is clearly important to know whether these abnormalities were transient and of no long-term clinical importance or whether progressive renal damage has subsequently occurred. Renal function was therefore reassessed biochemically and radiologically in 27 patients from the two centres 11 years after the initial investigations. In addition, we have investigated a new series of 30 haemophiliacs adequately treated on demand or by self-therapy for at least five years to determine if the incidence of renal abnormalities has decreased as a consequence of more active treatment"},{"key":"ref_11","unstructured":"Follow-up since 1969-Any change in renal function since 1969 was assessed in the 27 patients by the following investigations: (a) history of haematuria over the past five years graded as + +-haematuria exceeding a collective total of three weeks or requiring two or more hospital admissions or both, +-haematuria of less than a total of three weeks or requiring one hospital admission or both, 0-no clinical","article-title":"Follow-up since 1969-Any change in renal function since 1969 was assessed in the 27 patients by the following investigations: (a) history of haematuria over the past five years graded as + +-haematuria exceeding a collective total of three weeks or requiring two or more hospital admissions or both, +-haematuria of less than a total of three weeks or requiring one hospital admission or both, 0-no clinical"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.285.6355.1607","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.285.6355.1607","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T19:30:41Z","timestamp":1765308641000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.285.6355.1607"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,12,4]]},"references-count":11,"journal-issue":{"issue":"6355","published-online":{"date-parts":[[1982,12,4]]},"published-print":{"date-parts":[[1982,12,4]]}},"alternative-id":["10.1136\/bmj.285.6355.1607"],"URL":"https:\/\/doi.org\/10.1136\/bmj.285.6355.1607","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1982,12,4]]}}}