{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T19:40:32Z","timestamp":1765309232129,"version":"3.46.0"},"reference-count":35,"publisher":"BMJ","issue":"6356","license":[{"start":{"date-parts":[[1982,12,11]],"date-time":"1982-12-11T00:00:00Z","timestamp":408412800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1982,12,11]]},"abstract":"<jats:p>The effects of prostaglandin E1 infusion on nailfold capillary haemodynamics were studied in eight patients with Raynaud's phenomenon secondary to progressive systemic sclerosis. Using a modified Landis microinjection technique the mean (+\/- SEM) transcapillary pressure gradient was increased during and six weeks after infusion by 13.9 +\/- 3.2 cm H2O (p less than 0.05) and 5.5 +\/- 2.5 cm H2O (p less than 0.05) respectively. Capillary red cell velocity measured in two patients by video television microscopy also increased during and after infusion with prostaglandin E1. Six patients claimed subjective benefit and in three their ulcers healed. These findings support the observed beneficial effect of prostaglandin E1 and suggest that it improves the nutritive capillary circulation by lowering precapillary resistance.<\/jats:p>","DOI":"10.1136\/bmj.285.6356.1688","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1688-1690","source":"Crossref","is-referenced-by-count":21,"title":["Effects of prostaglandin E1 on microvascular haemodynamics in progressive systemic sclerosis."],"prefix":"10.1136","volume":"285","author":[{"given":"M F","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J E","family":"Tooke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1982,12,11]]},"reference":[{"issue":"1","key":"ref_1","first-page":"181","article-title":"Renal function in patients over 40 with homozygous sickle-cell disease","volume":"282","author":"Morgan, A.G.; Serjeant, G.R.","year":"1981","unstructured":"Morgan AG, Serjeant GR. Renal function in patients over 40 with homozygous sickle-cell disease. Br Med3 1981;282:1 181-3."},{"key":"ref_2","first-page":"\"49","article-title":"Bioassay of erythropoietin using foetal mouse liver cells","volume":"24","author":"Wardle, D.F.H.; Baker, I.; Malpas, J.S.; Wrigley, P.F.M.","year":"1973","unstructured":"Wardle DFH, Baker I, Malpas JS, Wrigley PFM. Bioassay of erythropoietin using foetal mouse liver cells. BrJ Haematol 1973;24:49-56. 3de Klerk G, Rosengarten PCJ, Vet JWM, Goudsmit R. Serum erythropoietin (ESF) titers in anemia. Blood 1981;58:1164-70.","journal-title":"BrJ Haematol; Serum erythropoietin (ESF) titers in anemia"},{"key":"ref_3","first-page":"\"225","article-title":"Erythropoietin in acute erythoblastopenia of sickle cell anemia","volume":"6","author":"Okcuoglu, A.","year":"1964","unstructured":"Okcuoglu A. Erythropoietin in acute erythoblastopenia of sickle cell anemia. Turk J Pediatr 1964;6:225-32. s Hammond D, Shore N, Movassaghi N. Production, utilization and excretion of erythropoietin. I Chronic anemias. II Aplastic crisis. III Erythropoietic effects of normal plasma. Ann NY Acad Sci 1968; 149:516-27.","journal-title":"Turk J Pediatr; Production, utilization and excretion of erythropoietin. I Chronic anemias. II Aplastic crisis. III Erythropoietic effects of normal plasma"},{"key":"ref_4","first-page":"438","article-title":"Erythropoietin excretion in bone marrow failure and hemolytic anemia","volume":"82","author":"Alexanian, R.","year":"1973","unstructured":"Alexanian R. Erythropoietin excretion in bone marrow failure and hemolytic anemia. J Lab Clin Med 1973;82:438-45.","journal-title":"J Lab Clin Med"},{"key":"ref_5","first-page":"289","article-title":"Erythropoiesis in sickle cell anaemia during acute infection and crisis","volume":"22","author":"Haddy, T.B.; Lusher, J.M.; Hendriks, S.; Trosko, B.K.","year":"1979","unstructured":"Haddy TB, Lusher JM, Hendriks S, Trosko BK. Erythropoiesis in sickle cell anaemia during acute infection and crisis. Scandj3 Haematol 1979;22:289-95."},{"key":"ref_6","first-page":"40","article-title":"Hormonal regulation of erythropoiesis. V. Relationship of plasma erythropoietin level to bone marrow activity","volume-title":"Proc Soc Exp Biol Med 1959","volume":"100","author":"Stohlman, F.; Brecher, G.","unstructured":"Stohlman F, Brecher G. Hormonal regulation of erythropoiesis. V. Relationship of plasma erythropoietin level to bone marrow activity. Proc Soc Exp Biol Med 1959;100:40-3."},{"issue":"60","key":"ref_7","first-page":"365","article-title":"Measurement of erythropoiesis stimulating factor in anemic patients with and without renal disease","volume":"1962","author":"Naets, J.-P.; Heuse, A.F.","unstructured":"Naets J-P, Heuse AF. Measurement of erythropoiesis stimulating factor in anemic patients with and without renal disease. J Lab Clin Med 1962;60:365-74.","journal-title":"J Lab Clin Med"},{"key":"ref_8","first-page":"528","article-title":"Erythropoiesis in chronic renal disease","volume":"88","author":"Zucker, S.; Lysik, R.M.; Mohammad, G.","year":"1976","unstructured":"Zucker S, Lysik RM, Mohammad G. Erythropoiesis in chronic renal disease. 7 Lab Clin Med 1976;88:528-35.","journal-title":"7 Lab Clin Med"},{"key":"ref_9","first-page":"449","article-title":"Erythropoietin levels in uremic nephric and anephric patients","volume":"33","year":"1979","unstructured":"Caro J, Brown S, Miller 0, Murray T, Erslev AJ. Erythropoietin levels in uremic nephric and anephric patients. 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Studies on a radioimmunoassay for human erythropoietin. J Lab Clin Med 1975;86:140-51. '4 Lange RD, Ichiki AT. Immunological studies of erythropoietin. In: Fisher JW, ed. Kidney hormones. Vol II. Erythropoietin. London: Academic Press, 1977: 111-49.","journal-title":"J Lab Clin Med; 4 Lange RD, Ichiki AT. Immunological studies of erythropoietin"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1136\/bmj.285.6342.633","article-title":"Causes of death in sickle-cell disease in Jamaica","volume":"285","author":"Thomas, A.N.; Pattinson, C.; Serjeant, G.R.","year":"1982","unstructured":"Thomas AN, Pattinson C, Serjeant GR. Causes of death in sickle-cell disease in Jamaica. Br MedJr 1982;285:633-5.","journal-title":"Br MedJr"},{"article-title":"Accepted 4","year":"1982","key":"ref_13","unstructured":"(Accepted 4 October 1982)"},{"key":"ref_14","unstructured":"The vascular abnormalities found in progressive systemic sclerosis constitute a prominent feature of the disease and mainly affect the microvascular circulation.' This association has led some workers to conclude that a microangiopathy might represent the underlying cause of the disease.2 Raynaud's phenomenon is a common and often early feature of the condition and the characteristic attacks of digital exsanguination may result in painful ischaemic ulceration, occasionally leading to gangrene that requires amputation.","article-title":"The vascular abnormalities found in progressive systemic sclerosis constitute a prominent feature of the disease and mainly affect the microvascular circulation.' This association has led some workers to conclude that a microangiopathy might represent the underlying cause of the disease.2 Raynaud's phenomenon is a common and often early feature of the condition and the characteristic attacks of digital exsanguination may result in painful ischaemic ulceration, occasionally leading to gangrene that requires amputation"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.7326\/0003-4819-73-2-317","article-title":"Pressure (cm H20) I Norton WL, Nardo JM. Vascular disease in progressive systemic sclerosis (scleroderma)","volume":"73","year":"1970","unstructured":"Pressure (cm H20) I Norton WL, Nardo JM. Vascular disease in progressive systemic sclerosis (scleroderma). Ann Int Med 1970;73:317-24.","journal-title":"Ann Int Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0049-0172(75)90017-7","article-title":"Pathogenesis of systemic sclerosis: a vascular hypothesis","volume":"4","author":"Campbell, P.M.; Leroy, E.C.","year":"1975","unstructured":"Campbell PM, Leroy EC. Pathogenesis of systemic sclerosis: a vascular hypothesis. Semin Arth Rheum 1975;4:351-68.","journal-title":"Semin Arth Rheum"},{"key":"ref_17","first-page":"473","article-title":"The skin microcirculation and the pathogenesis of ischaemic necrosis and gangrene. ScandJ3 Clin Lab Invest","volume":"37","author":"Fagrell, B.","year":"1977","unstructured":"Fagrell B. The skin microcirculation and the pathogenesis of ischaemic necrosis and gangrene. ScandJ3 Clin Lab Invest 1977;37:473-6."},{"key":"ref_18","first-page":"350","article-title":"Prostaglandin El infusions for vascular insufficiency in progressive systemic sclerosis","volume":"40","author":"Martin, M.F.R.; Dowd, P.M.; Ring, E.F.J.; Cooke, E.D.; Dieppe, P.A.; Kirby, J.D.T.","year":"1980","unstructured":"Martin MFR, Dowd PM, Ring EFJ, Cooke ED, Dieppe PA, Kirby JDT. Prostaglandin El infusions for vascular insufficiency in progressive systemic sclerosis. Ann Rheum Dis 1980;40:350-4.","journal-title":"Ann Rheum Dis"},{"key":"ref_19","first-page":"281","article-title":"Treatment of vasospastic disease with prostaglandin E","volume":"1980","author":"Clifford, P.C.; Martin, M.F.R.; Sheddon, E.J.; Kirby, J.D.; Baird, R.N.; Dieppe, P.A.","unstructured":"Clifford PC, Martin MFR, Sheddon EJ, Kirby JD, Baird RN, Dieppe PA. Treatment of vasospastic disease with prostaglandin E,. Br MedJf 1980: 281:1031-4.","journal-title":"Br MedJf"},{"key":"ref_20","first-page":"826","article-title":"Preliminary experience with prostaglandins E1 and I2 in peripheral vascular disease","volume":"88","author":"Pardy, B.J.; Lewis, J.D.; Eastcott, H.H.G.","year":"1980","unstructured":"Pardy BJ, Lewis JD, Eastcott HHG. Preliminary experience with prostaglandins E1 and I2 in peripheral vascular disease. Surgery 1980;88: 826-32.","journal-title":"Surgery"},{"issue":"15","key":"ref_21","first-page":"209","article-title":"Micro-injection studies of capillary blood pressure in human skin","volume":"1930","author":"Landis, E.M.","unstructured":"Landis EM. Micro-injection studies of capillary blood pressure in human skin. Heart 1930;15:209-28.","journal-title":"Heart"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"815","DOI":"10.2337\/diacare.20.10.815","article-title":"A capillary pressure disturbance in young diabetics","volume":"29","author":"Tooke, J.E.","year":"1980","unstructured":"Tooke JE. A capillary pressure disturbance in young diabetics. Diabetes 1980;29:815-9.","journal-title":"Diabetes"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0026-2862(74)90037-5","article-title":"Red blood cell velocity in nail fold capillaries of man, measured by a television microscopy technique","volume":"7","author":"Bollinger, A.; Butti, P.; Barras, J.-P.; Trachsler, H.; Siegenthaler, W.","year":"1974","unstructured":"Bollinger A, Butti P, Barras J-P, Trachsler H, Siegenthaler W. Red blood cell velocity in nail fold capillaries of man, measured by a television microscopy technique. Microvasc Res 1974;7:61-72.","journal-title":"Microvasc Res"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/jid.1966.143","article-title":"Nailfold capillaroscopy-a useful aid in the diagnosis of collagen vascular disease","volume":"47","author":"Ross, J.B.","year":"1966","unstructured":"Ross JB. Nailfold capillaroscopy-a useful aid in the diagnosis of collagen vascular disease. J Invest Derm 1966;47:282-5.","journal-title":"J Invest Derm"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1111\/j.1365-2133.1975.tb05119.x","article-title":"Arterial thrombosis in scleroderma","volume":"93","author":"Furey, N.L.; Schmid, F.R.; Kwaan, H.C.; Frederici, H.H.R.","year":"1975","unstructured":"Furey NL, Schmid FR, Kwaan HC, Frederici HHR. Arterial thrombosis in scleroderma. Br J Dermatol 1975;93:683-93.","journal-title":"Br J Dermatol"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/S0140-6736(68)90302-4","article-title":"Nailfold capillaries in connective tissue disorders","volume":"i:","author":"Buchanon, I.S.; Humpston, D.J.","year":"1968","unstructured":"Buchanon IS, Humpston DJ. Nailfold capillaries in connective tissue disorders. Lancet 1968;i:845-7.","journal-title":"Lancet"},{"issue":"15","key":"ref_27","first-page":"385","article-title":"Observations on arteriovenous anastomosis in the human skin and in bird's foot with special reference to the reaction to cold","volume":"1930","author":"Grant, R.T.; Bland, E.F.","unstructured":"Grant RT, Bland EF. Observations on arteriovenous anastomosis in the human skin and in bird's foot with special reference to the reaction to cold. Heart 1930;15:385-407.","journal-title":"Heart"},{"issue":"18","key":"ref_28","first-page":"1","article-title":"Measurement of cutaneous blood flow by freely diffusible radioactive isotopes","volume":"1971","author":"Serjsen, P.","unstructured":"Serjsen P. Measurement of cutaneous blood flow by freely diffusible radioactive isotopes. Dan Med Bull 1971;18 suppl 3:1-38.","journal-title":"Dan Med Bull"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1172\/JCI106565","article-title":"Skin capillary blood flow in scleroderma","volume":"50","author":"Leroy, E.C.; Downey, J.A.; Cannon, P.J.","year":"1971","unstructured":"Leroy EC, Downey JA, Cannon PJ. Skin capillary blood flow in scleroderma. J Clin Invest 1971;50:930-9.","journal-title":"J Clin Invest"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1056\/NEJM197903293001305","article-title":"Vasodilator drugs in peripheral vascular disease","volume":"300","author":"Coffman, J.D.","year":"1979","unstructured":"Coffman JD. Vasodilator drugs in peripheral vascular disease. N EnglJf Med 1979;300:713-7.","journal-title":"N EnglJf Med"},{"issue":"10","key":"ref_31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1001\/archderm.1974.01630080035009","article-title":"Medical uses of intra-arterial injections of reserpine","volume":"1","author":"Tindall, J.P.; Whalen, R.E.; Burton, E.","year":"1974","unstructured":"Tindall JP, Whalen RE, Burton E. Medical uses of intra-arterial injections of reserpine. Arch Dermatol 1974;1 10:233-7.","journal-title":"Arch Dermatol"},{"key":"ref_32","first-page":"523","article-title":"Treatment of Raynaud's phenomenon by fibrinolytic enhancement","volume":"ii:","author":"Jarrett, P.E.M.; Morland, M.; Browse, N.L.","year":"1978","unstructured":"Jarrett PEM, Morland M, Browse NL. Treatment of Raynaud's phenomenon by fibrinolytic enhancement. Br MedJ7 1978;ii:523-5."},{"key":"ref_33","first-page":"113","article-title":"Controlled trial of plasma exchange in treatment of Raynaud's syndrome","volume":"ii:","year":"1979","unstructured":"O'Reilly MJG, Talpos G, Roberts VC, White JM, Cotton LT. Controlled trial of plasma exchange in treatment of Raynaud's syndrome. Br MedJ3 1979;ii:113-5."},{"key":"ref_34","article-title":"PGE, vasospastic disease and thermography","author":"Kyle, M.V.; Parr, G.; Salisbury, R.; Thomas, P.P.; Hazleman, B.L.","year":"1982","unstructured":"Kyle MV, Parr G, Salisbury R, Thomas PP, Hazleman BL. PGE, vasospastic disease and thermography. Ann Rheum Dis 1982 (in press).","journal-title":"Ann Rheum Dis"},{"key":"ref_35","first-page":"42","article-title":"Prostaglandin El therapy for digital ulcers in scleroderma","volume":"126","author":"Baron, M.; Skrinskas, G.; Urowitz, M.B.; Madras, P.N.","year":"1982","unstructured":"Baron M, Skrinskas G, Urowitz MB, Madras PN. Prostaglandin El therapy for digital ulcers in scleroderma. 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