{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:06:09Z","timestamp":1765310769530,"version":"3.46.0"},"reference-count":8,"publisher":"BMJ","issue":"6359","license":[{"start":{"date-parts":[[1983,1,8]],"date-time":"1983-01-08T00:00:00Z","timestamp":410832000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,1,8]]},"abstract":"<jats:p>HLA-DRw6-positive patients are \"high responders\" to certain renal allograft antigens. A study was therefore conducted of the outcome of 247 first renal allografts in 74 DRw6-positive and 173 DRw6-negative recipients. The effectiveness of matching for HLA-DR determinants in both groups was also analysed. The one-year graft survival in DRw6-positive patients was 59% as compared with 75% in DRw6-negative recipients (p = 0.012). A striking difference between the two groups was that HLA-DR matching significantly improved renal allograft survival only in the DRw6-positive patients. In those patients the one-year survival of HLA-DR-identical grafts was 95% as compared with only 38% for 2-DR mismatched grafts (p = 0.009). In DRw6-negative patients only a slight beneficial effect of HLA-DR matching was observed (83% versus 72% at one year for the 0-DR and 2-DR mismatched grafts, respectively) (p greater than 0.05). These findings are clear evidence that DRw6-positive patients (about a quarter of the patients on the waiting list of Eurotransplant) should be given HLA-DR-identical kidney transplants only.<\/jats:p>","DOI":"10.1136\/bmj.286.6359.85","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"85-87","source":"Crossref","is-referenced-by-count":45,"title":["HLA-DRw6 and renal allograft rejection."],"prefix":"10.1136","volume":"286","author":[{"given":"G F","family":"Hendriks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G M","family":"Schreuder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F H","family":"Claas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"D'Amaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G G","family":"Persijn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J J","family":"van Rood","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,1,8]]},"reference":[{"key":"ref_1","first-page":"140","article-title":"Renal graft rejection and the antigenic anatomy of human kidneys. Thirteenth congress on transplantation and clinical imnmnunology","author":"Baldwin, W.M.; Claas, F.H.J.; van LA, Es","year":"1981","unstructured":"Baldwin WM, Claas FHJ, Es van LA, et al. Renal graft rejection and the antigenic anatomy of human kidneys. Thirteenth congress on transplantation and clinical imnmnunology, Lyon, 1981. Amsterdam: Excerpta Medica, 1981:140-6."},{"article-title":"NIH lymphocyte microcytotoxicity technique. NIAID manual of tissue typing techniques. (DHEW publication No (NIH) 77-545.)","author":"Ray, J.G.","key":"ref_2","unstructured":"Ray JG. NIH lymphocyte microcytotoxicity technique. NIAID manual of tissue typing techniques. (DHEW publication No (NIH) 77-545.) Washington, DC: DHEW, 1977:32."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1038\/262795a0","article-title":"Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants","volume":"262","author":"van JJ, Rood; van A, Leeuwen; JS, Ploem","year":"1976","unstructured":"Rood van JJ, Leeuwen van A, Ploem JS. Simultaneous detection of two cell populations by two-colour fluorescence and application to the recognition of B-cell determinants. Nature 1976;262:795-7.","journal-title":"Nature"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/bjc.1977.1","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient","volume":"35","author":"Peto, R.; Pike, M.C.; Armitage, P.","year":"1977","unstructured":"Peto R, Pike MC, Armitage P, et al. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples. Br J Cancer 1977;35: 1.","journal-title":"II. Analysis and examples. Br J Cancer"},{"key":"ref_5","first-page":"111","article-title":"Hierarchy of factors which influence kidney graft survival","volume":"11","author":"van JJ, Rood; GG, Persijn; B, Cohen; Q, Lansbergen; RKB, Schuurman","year":"1982","unstructured":"Rood van JJ, Persijn GG, Cohen B, Lansbergen Q, Schuurman RKB. Hierarchy of factors which influence kidney graft survival. Dialysis and Transplantation 1982;11:111-8.","journal-title":"Dialysis and Transplantation"},{"key":"ref_6","first-page":"1","article-title":"Overview of the 1980 international histocompatibility workshop","author":"Terasaki, P.I.; Park, M.S.; Bernoco, D.; Opelz, G.; Mickey, M.R.","year":"1980","unstructured":"Terasaki PI, Park MS, Bernoco D, Opelz G, Mickey MR. Overview of the 1980 international histocompatibility workshop. In: Terasaki PI, ed. Histocompatibility testing 1980. Los Angeles: UCLA Tissue Typing Laboratory, 1980:1-17."},{"article-title":"Accepted 15","year":"1982","key":"ref_7","unstructured":"(Accepted 15 October 1982)"},{"key":"ref_8","article-title":"The delta antigen\/antibody system was first described by Rizzetto and coworkers' in Italy in 1977 and has later been associated with a transmissible hepatitis agent, the delta agent, which can cause infection only when the hepatitis B virus genome is present. The delta agent is found all over the world.2 It was first discovered in southern Italy, where it is endemic and associated with serious liver damage,'","volume-title":"while in Northern Italy, as well as elsewhere in the","year":"haemophiliacs).","unstructured":"The delta antigen\/antibody system was first described by Rizzetto and coworkers' in Italy in 1977 and has later been associated with a transmissible hepatitis agent, the delta agent, which can cause infection only when the hepatitis B virus genome is present. The delta agent is found all over the world.2 It was first discovered in southern Italy, where it is endemic and associated with serious liver damage,' while in Northern Italy, as well as elsewhere in the world, it is prevalent among drug addicts (and haemophiliacs)."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6359.85","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6359.85","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:02:19Z","timestamp":1765310539000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6359.85"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1,8]]},"references-count":8,"journal-issue":{"issue":"6359","published-online":{"date-parts":[[1983,1,8]]},"published-print":{"date-parts":[[1983,1,8]]}},"alternative-id":["10.1136\/bmj.286.6359.85"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6359.85","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,1,8]]}}}