{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:11:01Z","timestamp":1765311061269,"version":"3.46.0"},"reference-count":17,"publisher":"BMJ","issue":"6361","license":[{"start":{"date-parts":[[1983,1,22]],"date-time":"1983-01-22T00:00:00Z","timestamp":412041600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,1,22]]},"abstract":"<jats:p>The relative fertility of sons and daughters of patients with Huntington's chorea was found to be a little under 0.5 if they had been told of their risk of transmitting the disease before they had started their families. The effect was much the same in those who had attended the genetic clinic at The Hospital for Sick Children on a single occasion and those who had been told of their risk directly, or indirectly through the patient's spouse or family doctor, by the neurologist who was looking after their affected parent at the National Hospital for Nervous Diseases. If all offspring of patients were informed of their risk the effect on the prevalence of the disorder would be substantial, especially if the mutation rate is low and the reproductive fitness of patients in the past has been close to 1.0. Men and women at risk of developing the disease should not be seen on just one occasion, however: they need continued support by being seen regularly at a special neurological genetic clinic.<\/jats:p>","DOI":"10.1136\/bmj.286.6361.281","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"281-283","source":"Crossref","is-referenced-by-count":19,"title":["Effect of genetic counselling on the prevalence of Huntington's chorea."],"prefix":"10.1136","volume":"286","author":[{"given":"C O","family":"Carter","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K A","family":"Evans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Baraitser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,1,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/jmg.14.5.316","article-title":"Monogenic disorders","volume":"14","author":"Carter, C.O.","year":"1977","unstructured":"Carter CO. Monogenic disorders. ] Med Genet 1977;14:316-20.","journal-title":"Med Genet"},{"key":"ref_2","first-page":"411","article-title":"Decline in predicted incidence of Huntington's chorea associated with systematic genetic counselling and family support","volume":"ii:","author":"Harper, P.S.; Tyler, A.; Smith, S.; Jones, P.; Newcombe, R.G.; McBroom, V.","year":"1981","unstructured":"Harper PS, Tyler A, Smith S, Jones P, Newcombe RG, McBroom V. Decline in predicted incidence of Huntington's chorea associated with systematic genetic counselling and family support. Lancet 1981;ii:411-3.","journal-title":"Lancet"},{"key":"ref_3","first-page":"346","article-title":"Huntington's chorea: the basis for long term prevention","volume":"ii:","author":"Harper, P.S.; Tyler, A.; Walker, D.A.; Newcombe, R.G.; Davies, K.","year":"1979","unstructured":"Harper PS, Tyler A, Walker DA, Newcombe RG, Davies K. Huntington's chorea: the basis for long term prevention. 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Huntington's chorea in Michigan: selection and mutation. Am]7 Hum Genet 1959;11:107-36."},{"key":"ref_14","series-title":"Proceedings of the Second International Congress of Human Genetics. Vol 2","article-title":"The fertility of patients with Huntington's chorea","author":"Wendt, G.G.","year":"1963","unstructured":"Wendt GG. The fertility of patients with Huntington's chorea. Proceedings of the Second International Congress of Human Genetics. Vol 2. Rome: Excerpta Medica, 1963."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1136\/jmg.19.3.161","article-title":"The mutation rate to Huntington's chorea","volume":"19","author":"Shaw, M.; Caro, A.","year":"1982","unstructured":"Shaw M, Caro A. The mutation rate to Huntington's chorea. 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Br Medy 1982;284: 1383-5.","journal-title":"Br Medy"},{"year":"1982","unstructured":"(Accepted 25 November 1982)","article-title":"Accepted 25","key":"ref_17"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6361.281","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6361.281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:08:14Z","timestamp":1765310894000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6361.281"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,1,22]]},"references-count":17,"journal-issue":{"issue":"6361","published-online":{"date-parts":[[1983,1,22]]},"published-print":{"date-parts":[[1983,1,22]]}},"alternative-id":["10.1136\/bmj.286.6361.281"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6361.281","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,1,22]]}}}