{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:20:31Z","timestamp":1765311631762,"version":"3.46.0"},"reference-count":17,"publisher":"BMJ","issue":"6363","license":[{"start":{"date-parts":[[1983,2,5]],"date-time":"1983-02-05T00:00:00Z","timestamp":413251200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,2,5]]},"abstract":"<jats:p>A double blind trial of three oral preparations given in single doses for the treatment of Schistosoma haematobium infection was carried out in schoolchildren; selection was biased towards those who excreted large quantities of eggs. Praziquantel 40 mg\/kg was the most effective drug giving a greater than 97% reduction in egg output six months after treatment; combined treatment with niridazole 25 mg\/kg and metrifonate 10 mg\/kg gave a reduction of greater than 92% and metrifonate 10 mg\/kg alone a reduction of greater than 86%. Fewer children continued to have moderate to heavy infections (excretion greater than 124 ova\/10 ml urine) six months after treatment with praziquantel (5%) and the combined regimen (7%) than with metrifonate (16%). Though our findings show that praziquantel appears to be the most effective and convenient drug available for individuals with S haematobium infection, the combined regimen is a cheaper alternative for treatment where cost is important and parasitological cure not an essential objective.<\/jats:p>","DOI":"10.1136\/bmj.286.6363.429","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"429-432","source":"Crossref","is-referenced-by-count":20,"title":["Single dose oral treatment in urinary schistosomiasis: a double blind trial."],"prefix":"10.1136","volume":"286","author":[{"given":"R N","family":"Pugh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C H","family":"Teesdale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,2,5]]},"reference":[{"key":"ref_1","first-page":"773","article-title":"Initial experiences with praziquantel in the treatment of human infections due to Schistosoma haematobium","volume":"57","author":"lDavis A; JE, Biles; A-M, Ulrich","year":"1979","unstructured":"lDavis A, Biles JE, Ulrich A-M. Initial experiences with praziquantel in the treatment of human infections due to Schistosoma haematobium. Bull WHO 1979;57:773-9.","journal-title":"Bull WHO"},{"issue":"78","key":"ref_2","first-page":"1","article-title":"Preliminary trials with praziquantel in human infections due to Schistosoma mansoni","volume":"57","author":"Katz, N.; Rocha, R.S.; Chaves, A.","year":"1979","unstructured":"Katz N, Rocha RS, Chaves A. Preliminary trials with praziquantel in human infections due to Schistosoma mansoni. Bull WHO 1979;57: 78 1-5.","journal-title":"Bull WHO"},{"key":"ref_3","first-page":"793","article-title":"Preliminary clinical trials with praziquantel in Schistosoma japonicum infections in the Philippines","volume":"57","author":"Santes, A.T.; Blas, B.L.; Nosenas, J.S.","year":"1979","unstructured":"Santes AT, Blas BL, Nosenas JS, et al. Preliminary clinical trials with praziquantel in Schistosoma japonicum infections in the Philippines. Bull WHO 1979;57:793-9.","journal-title":"Bull WHO"},{"key":"ref_4","first-page":"635","article-title":"Praziquantel: a new hope for schistosomiasis (Editorial)","volume":"i:","author":"Anonymous","year":"1980","unstructured":"Anonymous. Praziquantel: a new hope for schistosomiasis (Editorial). Lancet 1980;i:635-6.","journal-title":"Lancet"},{"key":"ref_5","first-page":"856","article-title":"Quantification of infection with Schistosoma haematobium in relation to epidemiology and selective population chemotherapy. II Mass treatment with a single oral dose of metriphonate. J7 Infect","volume":"38","author":"Siongok, T.K.A.; Ouma, J.H.; Houser, H.B.; Warren, K.S.","year":"1978","unstructured":"Siongok TKA, Ouma JH, Houser HB, Warren KS. Quantification of infection with Schistosoma haematobium in relation to epidemiology and selective population chemotherapy. II Mass treatment with a single oral dose of metriphonate. 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Trans Assoc Am Physicians 1976;89: 195-202.","journal-title":"Trans Assoc Am Physicians"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/0035-9203(81)90216-9","article-title":"A note on drug trials in schistosomiasis","volume":"75","author":"McMahon, J.E.","year":"1981","unstructured":"McMahon JE. A note on drug trials in schistosomiasis. Trans R Soc Trop Med Hyg 1981;75:597-8.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1080\/00034983.1978.11719333","article-title":"A filtration method for schistosome egg quantification","volume":"72","author":"Pugh, R.N.H.","year":"1978","unstructured":"' Pugh RNH. A filtration method for schistosome egg quantification. Ann Trop Med Parasitol 1978;72:387-8.","journal-title":"Ann Trop Med Parasitol"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0035-9203(82)90204-8","article-title":"Simultaneous use of a sensitive filtration technique and reagent strips in urinary schistosomiasis","volume":"76","author":"Feldmeier, H.; Doehring, E.; Daffalla, A.A.","year":"1982","unstructured":"Feldmeier H, Doehring E, Daffalla AA. Simultaneous use of a sensitive filtration technique and reagent strips in urinary schistosomiasis. Trans R Soc Trop Med Hyg 1982;76:416-21.","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1080\/00034983.1980.11687393","article-title":"Malumfashi endemic diseases research project. XV The potential medical importance of bilharzia in northern Nigeria; a suggested rapid, cheap and effective solution for control of Schistosoma haematobium infection","volume":"74","author":"t3 Pugh RNH; DR, Bell; HM, Gilles","year":"1980","unstructured":"t3 Pugh RNH, Bell DR, Gilles HM. Malumfashi endemic diseases research project. XV The potential medical importance of bilharzia in northern Nigeria; a suggested rapid, cheap and effective solution for control of Schistosoma haematobium infection. Ann Trop Med Parasitol 1980;74: 597-613.","journal-title":"Ann Trop Med Parasitol"},{"issue":"41","key":"ref_14","first-page":"209","article-title":"Metrifonate in urinary schistosomiasis","volume":"1969","unstructured":"Davis A, Bailey DR. Metrifonate in urinary schistosomiasis. 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