{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:51:08Z","timestamp":1765313468799,"version":"3.46.0"},"reference-count":7,"publisher":"BMJ","issue":"6369","license":[{"start":{"date-parts":[[1983,3,19]],"date-time":"1983-03-19T00:00:00Z","timestamp":416880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,3,19]]},"abstract":"<jats:p>Activities of serum long acting thyroid stimulator protector were measured in a series of nine pregnancies in eight mothers who had Graves' disease, one of whom had been successfully treated by surgery. In all but two instances the activities tended to decline as pregnancy progressed. After delivery activities rose in three out of five patients in whom these had disappeared in pregnancy and, as this occurred, the patients relapsed. In the two patients whose activities did not decline thyrotoxicosis persisted throughout pregnancy and after delivery. None of the nine babies in this study suffered from neonatal thyrotoxicosis because maternal activities of the thyroid stimulator protector, though high enough to induce Graves' disease in adults, were not above the threshold for the induction of thyroid overactivity in neonates.<\/jats:p>","DOI":"10.1136\/bmj.286.6369.934","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"934-935","source":"Crossref","is-referenced-by-count":15,"title":["Serum long acting thyroid stimulator protector in pregnancy complicated by Graves' disease."],"prefix":"10.1136","volume":"286","author":[{"given":"C A","family":"Hardisty","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D S","family":"Munro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,3,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1677\/joe.0.0630427","article-title":"Some factors affecting the detection of long acting thyroid stimulator protector using the McKenzie bioassay","volume":"63","author":"Dirmikis, S.","year":"1974","unstructured":"Dirmikis S. Some factors affecting the detection of long acting thyroid stimulator protector using the McKenzie bioassay. J Endocrinol 1974;63: 427-38.","journal-title":"J Endocrinol"},{"key":"ref_2","first-page":"613","article-title":"Relationship between long acting thyroid stimulator protector and the course of Graves's disease","author":"Hardisty, C.A.; Munro, D.S.","year":"1980","unstructured":"Hardisty CA, Munro DS. Relationship between long acting thyroid stimulator protector and the course of Graves's disease. In: Stockiet JR, Nagataki S, eds. Thyroid research VIII. Melbourne: Australian Academy of Science, 1980:613-6.","journal-title":"Thyroid research VIII. Melbourne: Australian Academy of Science"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/0002-9378(58)90651-3","article-title":"Studies of children born to mothers with thyroid disease","volume":"75","author":"Man, E.B.; Shaver, B.A.; Cooke, R.E.","year":"1958","unstructured":"Man EB, Shaver BA, Cooke RE. Studies of children born to mothers with thyroid disease. Am J Obstet Gynecol 1958;75:728-41.","journal-title":"Am J Obstet Gynecol"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1111\/j.1471-0528.1978.tb15839.x","article-title":"The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis","volume":"85","author":"Munro, D.S.; Dirmikis, S.M.; Humphries, H.; Smith, T.; Broadhead, G.D.","year":"1978","unstructured":"Munro DS, Dirmikis SM, Humphries H, Smith T, Broadhead GD. The role of thyroid stimulating immunoglobulins of Graves's disease in neonatal thyrotoxicosis. BrJ Obstet Gynaecol 1978;85:837-43.","journal-title":"BrJ Obstet Gynaecol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1056\/NEJM198008073030603","article-title":"Carbimazole and the autoimmune response in Graves'","volume":"303","author":"McGregor, A.M.; Petersen, M.M.; McLachlan, S.M.; Rooke, P.; Smith, B.R.; Hall, R.","year":"1980","unstructured":"McGregor AM, Petersen MM, McLachlan SM, Rooke P, Smith BR, Hall R. Carbimazole and the autoimmune response in Graves' disease. N Engi J Med 1980;303:302-7.","journal-title":"disease. N Engi J Med"},{"key":"ref_6","first-page":"30","article-title":"Change of serum antithyroid antibodies during and after pregnancy in autoimmune thyroid diseases. Clin Exp Immunol","volume":"31","author":"Amino, N.; Kuro, R.; Tanizawa, O.","year":"1978","unstructured":"Amino N, Kuro R, Tanizawa O, et al. Change of serum antithyroid antibodies during and after pregnancy in autoimmune thyroid diseases. Clin Exp Immunol 1978;31:30-7."},{"article-title":"Accepted 21","year":"1983","key":"ref_7","unstructured":"(Accepted 21 january 1983)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6369.934","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6369.934","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:46:28Z","timestamp":1765313188000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6369.934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,19]]},"references-count":7,"journal-issue":{"issue":"6369","published-online":{"date-parts":[[1983,3,19]]},"published-print":{"date-parts":[[1983,3,19]]}},"alternative-id":["10.1136\/bmj.286.6369.934"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6369.934","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,3,19]]}}}