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All four provocations produced comparable mean reductions in forced expired volume in one second in the asthmatic patients, but no reduction was obtained in the controls. Whereas exercise, hyperventilation of cold air, and hyperventilation of room air were associated with heat loss from airways, inhalation of nebulised distilled water was not. Inhalation of ultrasonically nebulised distilled water offers a simple additional diagnostic test for asthma. Changes in the osmolality of airway surface liquid may possibly be the common mechanism by which \"fog\" and hyperventilation produce bronchoconstruction.<\/jats:p>","DOI":"10.1136\/bmj.286.6370.1012","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1012-1014","source":"Crossref","is-referenced-by-count":16,"title":["Bronchial reactivity in asthmatic adults with normal spirometric values."],"prefix":"10.1136","volume":"286","author":[{"given":"T","family":"Higenbottam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T C","family":"Stokes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Jamieson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Hill","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,3,26]]},"reference":[{"key":"ref_1","article-title":"Adult asthma","author":"Clark, T.J.H.","unstructured":"Clark TJH. 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Oxford: Blackwell Scientific, 1971:223."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1136\/thx.36.8.596","article-title":"Hyperventilation or exercise to induce asthma","volume":"36","author":"Tweedal, P.L.M.; Godden, D.J.; Grant, I.W.B.","year":"1981","unstructured":"Tweedal PLM, Godden DJ, Grant IWB. Hyperventilation or exercise to induce asthma. Thorax 1981;36:596-8.","journal-title":"Thorax"},{"issue":"407-12","key":"ref_10","first-page":"3","article-title":"Hyperventilation induced central hypoxia","volume":"22","author":"Kenneal, J.A.; McLennan, J.E.; London, R.G.; McLaurin, R.L.","year":"1980","unstructured":"Kenneal JA, McLennan JE, London RG, McLaurin RL. Hyperventilation induced central hypoxia. Am Rev Respir Dis 1980;22:407-12.:3 Juniper EF, Frith PA, Durret C, Cockcroft DW, Hargreaves FE. Reproductability and comparison of responses to inhaled histamine and methacholine. Thorax 1978;33:705-10. '4 Chai H, Farr RS, Froehlich LA, et al. 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'6"},{"key":"ref_12","first-page":"172","article-title":"Localization of antigen in experimental bronchoconstriction in guinea pigs. _7 Allergy Clin Immunol","volume":"52","author":"Richardson, J.B.; Hogg, J.C.; Bouchard, T.; Hall, D.L.","year":"1973","unstructured":"Richardson JB, Hogg JC, Bouchard T, Hall DL. Localization of antigen in experimental bronchoconstriction in guinea pigs. _7 Allergy Clin Immunol 1973;52:172-81."},{"key":"ref_13","first-page":"\"161","article-title":"The effects of cromolyn sodium on the response to respiratory heat loss in normal subjects","volume":"123","author":"Fanta, C.H.; McFadden, E.R.; Ingram, R.H.","year":"1981","unstructured":"Fanta CH, McFadden ER, Ingram RH. The effects of cromolyn sodium on the response to respiratory heat loss in normal subjects. Am Rev Respir Dis 1981;123:161-4. '9 Breslin FJ, McFadden ER, Ingram RH. The effects of cromolyn sodium on the airway response to hypernea and cold air in asthma. Am Rev Respir Dis 1980;122:11-6.","journal-title":"Am Rev Respir Dis; The effects of cromolyn sodium on the airway response to hypernea and cold air in asthma"},{"key":"ref_14","author":"Accepted 20 Januiary 1983)","unstructured":"(Accepted 20 Januiary 1983)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6370.1012","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6370.1012","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:50:53Z","timestamp":1765313453000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6370.1012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,3,26]]},"references-count":14,"journal-issue":{"issue":"6370","published-online":{"date-parts":[[1983,3,26]]},"published-print":{"date-parts":[[1983,3,26]]}},"alternative-id":["10.1136\/bmj.286.6370.1012"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6370.1012","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"value":"0007-1447","type":"print"},{"value":"1468-5833","type":"electronic"}],"subject":[],"published":{"date-parts":[[1983,3,26]]}}}