{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T21:04:58Z","timestamp":1765314298260,"version":"3.46.0"},"reference-count":12,"publisher":"BMJ","issue":"6372","license":[{"start":{"date-parts":[[1983,4,9]],"date-time":"1983-04-09T00:00:00Z","timestamp":418694400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,4,9]]},"abstract":"<jats:p>Twenty five patients with hyperprolactinaemia were treated with pergolide mesylate, a new dopamine receptor agonist. Twenty three received treatment for six to 20 months, and in all serum prolactin concentrations were considerably reduced. In most patients prolactin concentrations were maintained in the normal range by a low, once daily dose of pergolide and reversal of associated reproductive disorders was observed. Tumour volume as assessed by computed tomography decreased considerably during treatment in three out of four patients with a pituitary tumour. The drug was well tolerated. Side effects were similar to those of bromocriptine, but four out of eight patients who had been forced to stop taking bromocriptine because of untoward effects were subsequently able to tolerate treatment with pergolide. Pergolide mesylate promises to be a useful addition to the currently available long acting dopamine agonists in the management of hyperprolactinaemia.<\/jats:p>","DOI":"10.1136\/bmj.286.6372.1177","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1177-1179","source":"Crossref","is-referenced-by-count":22,"title":["Effectiveness of pergolide mesylate in long term treatment of hyperprolactinaemia."],"prefix":"10.1136","volume":"286","author":[{"given":"S","family":"Franks","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P M","family":"Horrocks","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S S","family":"Lynch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W R","family":"Butt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D R","family":"London","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,4,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1126\/science.382359","article-title":"Pharmacologic effects in man of a potent long-acting dopamine receptor agonist","volume":"205","author":"Lemberger, L.; Crabtree, R.E.","year":"1979","unstructured":"Lemberger L, Crabtree RE. 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Br J Obstet Gynaecol 1977;84: 241-51.","journal-title":"Br J Obstet Gynaecol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1056\/NEJM197902083000606","article-title":"Reduction in size of a pituitary tumour by bromocriptine therapy","volume":"300","author":"McGregor, A.M.; Scanlon, M.F.; Hall, K.; Cook, D.B.; Hall, R.","year":"1979","unstructured":"McGregor AM, Scanlon MF, Hall K, Cook DB, Hall R. Reduction in size of a pituitary tumour by bromocriptine therapy. N Engl J Med 1979;300:291-3.","journal-title":"N Engl J Med"},{"key":"ref_9","first-page":"66","article-title":"Reduction of pituitary tumour size in patients with prolactinomas and acromegaly treated with bromocriptine with or without radiotherapy","volume":"ii:","author":"Wass, J.A.H.; Thorner, M.O.; Charlesworth, M.","year":"1979","unstructured":"Wass JAH, Thorner MO, Charlesworth M, et al. Reduction of pituitary tumour size in patients with prolactinomas and acromegaly treated with bromocriptine with or without radiotherapy. Lancet 1979;ii:66-9.","journal-title":"Lancet"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1136\/bmj.285.6340.465","article-title":"Reduction in size of prolactin-secreting tumours in men treated with pergolide","volume":"285","author":"Kendall-Taylor, P.; Hall, K.; Johnston, D.G.; Prescott, R.W.G.","year":"1982","unstructured":"Kendall-Taylor P, Hall K, Johnston DG, Prescott RWG. Reduction in size of prolactin-secreting tumours in men treated with pergolide. Br MedJ 1982;285:465-7.","journal-title":"Br MedJ"},{"key":"ref_11","first-page":"944","article-title":"Study on the relationship between plasma prolactin levels and androgen metabolism in man","volume":"43","author":"Magrini, G.; Ebiner, JR, Burckhardt; P, Felker; J.P.","year":"1967","unstructured":"Magrini G, Ebiner JR, Burckhardt P, Felker JP. Study on the relationship between plasma prolactin levels and androgen metabolism in man. J Clin Endocrinol Metab 1967;43:944-6.","journal-title":"J Clin Endocrinol Metab"},{"author":"Accepted 25_January 1983)","key":"ref_12","unstructured":"(Accepted 25_January 1983)"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6372.1177","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6372.1177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T20:59:59Z","timestamp":1765313999000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6372.1177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,4,9]]},"references-count":12,"journal-issue":{"issue":"6372","published-online":{"date-parts":[[1983,4,9]]},"published-print":{"date-parts":[[1983,4,9]]}},"alternative-id":["10.1136\/bmj.286.6372.1177"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6372.1177","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,4,9]]}}}