{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:24:09Z","timestamp":1777695849827,"version":"3.51.4"},"reference-count":18,"publisher":"BMJ","issue":"6375","license":[{"start":{"date-parts":[[1983,4,30]],"date-time":"1983-04-30T00:00:00Z","timestamp":420508800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,4,30]]},"abstract":"<jats:p>Meconium ileus equivalent is one of the lesser known manifestations of cystic fibrosis, and occurs most often in older patients. With the improved overall survival of patients with cystic fibrosis, one would expect to see this condition more often in the future. Of 53 patients attending our cystic fibrosis clinic for adolescents and adults, eight had experienced a total of 25 episodes of meconium ileus equivalent. Recurrent attacks occurred in seven patients, of whom four had at least four separate, well documented episodes: these episodes were associated with obvious recognised precipitating factors in only three patients. All patients responded to appropriate medical treatment with acetylcysteine or sodium diatrizoate, including three who had previously undergone surgery for meconium ileus equivalent elsewhere. Controversies remain, however, concerning the role of prophylactic medical management with acetylcysteine, sodium diatrizoate, and pancreatic supplements.<\/jats:p>","DOI":"10.1136\/bmj.286.6375.1411","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"1411-1413","source":"Crossref","is-referenced-by-count":24,"title":["Meconium ileus equivalent in older patients with cystic fibrosis."],"prefix":"10.1136","volume":"286","author":[{"given":"J G","family":"Hanly","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M X","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,4,30]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S0016-5085(81)80027-3","article-title":"Gastrointestinal manifestations of cystic fibrosis: a review","volume":"81","author":"Park, R.W.; Grand, R.J.","year":"1981","unstructured":"Park RW, Grand RJ. Gastrointestinal manifestations of cystic fibrosis: a review. Gastroenterology 1981;81:1143-61.","journal-title":"Gastroenterology"},{"key":"ref_2","first-page":"121","article-title":"Cystic fibrosis in adults, 75 cases and a review of 232 cases in the literature","volume":"66","author":"di Sant' Agnese PA; PB, Davis","year":"1979","unstructured":"di Sant' Agnese PA, Davis PB. Cystic fibrosis in adults, 75 cases and a review of 232 cases in the literature. Am J Med 1979;66:121-32.","journal-title":"Am J Med"},{"key":"ref_3","first-page":"732","article-title":"Meconium ileus equivalent complicating cystic fibrosis in post","volume-title":"neonatal children and young adults. Gastroenterology 1977; 72","author":"Matseshe JE, Go VLW, Di Magno EP","unstructured":"Matseshe JE, Go VLW, Di Magno EP. Meconium ileus equivalent complicating cystic fibrosis in post neonatal children and young adults. 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Physicochemical differences of mucoproteins in duodenal fluid of patients with cystic fibrosis of the pancreas and controls. Pediatrics 1957;19:252-60.","journal-title":"Pediatrics"},{"key":"ref_8","first-page":"201","article-title":"Mucoviscidosis ileus","volume":"128","author":"Hallberg, D.","year":"1964","unstructured":"Hallberg D. Mucoviscidosis ileus. Acta Chir Scand 1964;128:201-9.","journal-title":"Acta Chir Scand"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1136\/bmj.2.4987.286","article-title":"Intestinal obstruction as a late complication of fibrocystic disease of the pancreas","volume":"3","author":"Birse, E.L.","year":"1956","unstructured":"Birse EL. Intestinal obstruction as a late complication of fibrocystic disease of the pancreas. Br Med 3 1956;ii:286.","journal-title":"Br Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/oxfordjournals.bmb.a071462","article-title":"Meconium in health and disease","volume":"34","author":"Harries, J.T.","year":"1978","unstructured":"Harries JT. Meconium in health and disease. Br Med Bull 1978;34:75-8.","journal-title":"Br Med Bull"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1097\/00005792-197703000-00004","article-title":"Cystic fibrosis: a new outlook, 70 patients above 25 years of age","volume":"56","author":"Shwachman, H.; Kowalski, M.; Khaw, K.T.","year":"1977","unstructured":"Shwachman H, Kowalski M, Khaw KT. Cystic fibrosis: a new outlook, 70 patients above 25 years of age. Medicine 1977;56:129-49.","journal-title":"Medicine"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1542\/peds.48.1.51","article-title":"Intussusception in patients with cystic fibrosis","volume":"48","author":"Holsclaw, D.; Rocmans, C.; Shwachman, H.","year":"1971","unstructured":"Holsclaw D, Rocmans C, Shwachman H. Intussusception in patients with cystic fibrosis. Pediatrics 1971;48:51-8.","journal-title":"Pediatrics"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1542\/peds.21.6.893","article-title":"The islets of Langerhans in pancreatic cystic fibrosis","volume":"21","author":"Larsson, Y.","year":"1958","unstructured":"Larsson Y. The islets of Langerhans in pancreatic cystic fibrosis. Pediatrics 1958;21:893-902.","journal-title":"Pediatrics"},{"key":"ref_14","first-page":"\"288","article-title":"The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent n-acetylcysteine","volume":"106","author":"Sheffner, A.","year":"1963","unstructured":"Sheffner A. The reduction in vitro in viscosity of mucoprotein solutions by a new mucolytic agent n-acetylcysteine. Ann NY Acad Sci 1963; 106:288-97. 5, Lillibridge CB, Docter JM, Eidelman S. Oral administration of n-acetyl cysteine in the prophylaxis of \"meconium ileus equivalent.\" 7 Pediatr 1967;71:887-9.","journal-title":"Acad Sci; Oral administration of n-acetyl cysteine in the prophylaxis of \"meconium ileus equivalent"},{"key":"ref_15","first-page":"477","article-title":"Cystic fibrosis with faecal retention (meconium ileus equivalent): report of two cases","volume-title":"Mayo Clin Proc 1965","volume":"40","author":"Sigler, R.M.; Reeves, H.H.; Lynn, H.B.; Burke, E.C.","unstructured":"Sigler RM, Reeves HH, Lynn HB, Burke EC. Cystic fibrosis with faecal retention (meconium ileus equivalent): report of two cases. 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