{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T21:48:38Z","timestamp":1765316918773,"version":"3.46.0"},"reference-count":32,"publisher":"BMJ","issue":"6383","license":[{"start":{"date-parts":[[1983,6,25]],"date-time":"1983-06-25T00:00:00Z","timestamp":425347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,6,25]]},"abstract":"<jats:p>The biochemical disturbance produced by thiazide diuretics and by amiloride during treatment of moderate hypertension were compared. Two parallel studies were initiated. In one 40 patients with newly diagnosed hypertension were treated with metoprolol and a diuretic, either hydrochlorothiazide or amiloride. In a second study 38 patients receiving longstanding treatment with hypotensives and thiazides either continued the treatment or replaced the thiazide with amiloride. Initial biochemical assessments were compared with those after two years in the study. In previously untreated patients, thiazide produced a significant fall in plasma potassium and hyperuricaemia that did not occur with amiloride (p less than 0.001). Those patients receiving long term treatment for their hypertension who continued to take thiazides had persistent hypokalaemia and hyperuricaemia. Substitution with amiloride corrected the hypokalaemia and serum uric acid returned toward normal ranges, but this change was not statistically significant. Patients receiving long term treatment also had impaired glucose tolerance, this remained unchanged in those receiving thiazide but was corrected in those receiving amiloride. Compared with amiloride thiazides produced undesirable but reversible biochemical changes. As control of hypertension was equally effective with both preparations, we suggest that a combination of amiloride with a beta blocker in treatment of moderate hypertension in preferred.<\/jats:p>","DOI":"10.1136\/bmj.286.6383.2015","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"2015-2018","source":"Crossref","is-referenced-by-count":12,"title":["Comparison of thiazides and amiloride in treatment of moderate hypertension."],"prefix":"10.1136","volume":"286","author":[{"given":"J P","family":"Thomas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W H","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,6,25]]},"reference":[{"key":"ref_1","first-page":"422","article-title":"Amiloride hydrochloride in hypertensive patients. Br MedJ'","volume":"i:","author":"Paterson, J.W.; Dollery, C.T.; Haslam, R.M.","year":"1968","unstructured":"Paterson JW, Dollery CT, Haslam RM. Amiloride hydrochloride in hypertensive patients. Br MedJ' 1968;i:422-3."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/0026-0495(70)90118-6","article-title":"Possible predisposition of diabetic patients to hyperkalaemia following administration of potassium-retaining diuretic, amiloride","volume":"19","author":"McNay, J.L.; Oran, E.","year":"1970","unstructured":"McNay JL, Oran E. Possible predisposition of diabetic patients to hyperkalaemia following administration of potassium-retaining diuretic, amiloride. Metabolism 1970;19:58-69.","journal-title":"Metabolism"},{"key":"ref_3","first-page":"337","article-title":"A random-zero sphygmomanometer","volume":"i:","author":"Wright, B.M.; Dore, C.F.","year":"1970","unstructured":"Wright BM, Dore CF. A random-zero sphygmomanometer. 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Arch Intern Med 1973;132:44-54.","journal-title":"Arch Intern Med"},{"key":"ref_26","first-page":"986","article-title":"Effect of diuretic therapy on glucose tolerance in hypertensive patients","volume":"i:","author":"Kohner, E.M.; Dollery, C.T.; Lowy, C.; Schumer, B.","year":"1971","unstructured":"Kohner EM, Dollery CT, Lowy C, Schumer B. Effect of diuretic therapy on glucose tolerance in hypertensive patients. Lancet 1971;i:986-90.","journal-title":"Lancet"},{"key":"ref_27","first-page":"564","article-title":"Deterioration of glucose tolerance in hypertensive patients on prolonged diuretic treatment","volume":"i:","author":"Lewis, P.J.; Kohner, E.M.; Petrie, A.; Dollery, C.T.","year":"1976","unstructured":"Lewis PJ, Kohner EM, Petrie A, Dollery CT. Deterioration of glucose tolerance in hypertensive patients on prolonged diuretic treatment. 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Diabetologia 1979;16:25-30.","journal-title":"Diabetologia"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/S0140-6736(80)92651-3","article-title":"Coronary heart disease risk and impaired glucose tolerance","volume":"i:","author":"Fuller, J.H.; Shipley, M.J.; Rose, G.","year":"1980","unstructured":"Fuller JH, Shipley MJ, Rose G, et al. Coronary heart disease risk and impaired glucose tolerance. Lancet 1980;i:1373-6.","journal-title":"Lancet"},{"article-title":"Accepted","year":"1983","key":"ref_31","unstructured":"(Accepted 7 April 1983)"},{"issue":"78 1","key":"ref_32","article-title":"Many patients over the age of 55 with end stage renal disease in the United Kingdom are denied dialysis or transplantation. Although the reasons are complex, anticipation of a poor prognosis for these patients might explain why most British renal units impose an arbitrary age limit on the acceptance of patients for treatment. A study was therefore conducted to examine the prognosis and quality of life of 64 patients (mean age 59-6 years, range 55-72) accepted into our renal replacement programme from the beginning of 1975. The five year survival of the patients was","volume-title":"of the survivors either having successful transplants or caring for themselves using home haemodialysis or continuous ambulatory peritoneal dialysis","volume":"0","unstructured":"Many patients over the age of 55 with end stage renal disease in the United Kingdom are denied dialysis or transplantation. Although the reasons are complex, anticipation of a poor prognosis for these patients might explain why most British renal units impose an arbitrary age limit on the acceptance of patients for treatment. A study was therefore conducted to examine the prognosis and quality of life of 64 patients (mean age 59-6 years, range 55-72) accepted into our renal replacement programme from the beginning of 1975. The five year survival of the patients was 62 0%, with 78 1% of the survivors either having successful transplants or caring for themselves using home haemodialysis or continuous ambulatory peritoneal dialysis."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.286.6383.2015","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.286.6383.2015","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T21:44:53Z","timestamp":1765316693000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.286.6383.2015"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,6,25]]},"references-count":32,"journal-issue":{"issue":"6383","published-online":{"date-parts":[[1983,6,25]]},"published-print":{"date-parts":[[1983,6,25]]}},"alternative-id":["10.1136\/bmj.286.6383.2015"],"URL":"https:\/\/doi.org\/10.1136\/bmj.286.6383.2015","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,6,25]]}}}