{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T21:56:19Z","timestamp":1765317379825,"version":"3.46.0"},"reference-count":25,"publisher":"BMJ","issue":"6385","license":[{"start":{"date-parts":[[1983,7,9]],"date-time":"1983-07-09T00:00:00Z","timestamp":426556800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,7,9]]},"abstract":"<jats:p>In a group of patients who suffered from chronic ill health after an attack of acute infectious mononucleosis a disorder of T cell regulation was found. By means of cytochemical reactions the staining pattern associated with T suppressor cells was found in a greater percentage and that associated with T helper cells in a smaller percentage than in normal subjects. In a few patients this finding was confirmed in a functional suppressor assay. The patients were unwell for at least a year but most later made a complete recovery, which was associated with return to normal of the lymphocyte subsets.<\/jats:p>","DOI":"10.1136\/bmj.287.6385.85","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"85-88","source":"Crossref","is-referenced-by-count":39,"title":["Immunological reason for chronic ill health after infectious mononucleosis."],"prefix":"10.1136","volume":"287","author":[{"given":"T J","family":"Hamblin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A N","family":"Akbar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y C","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D B","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,7,9]]},"reference":[{"key":"ref_1","first-page":"704","article-title":"Recurrence of infectious mononucleosis","volume":"i:","author":"RS, I.Chang; R, Maddock","year":"1980","unstructured":"I Chang RS, Maddock R. Recurrence of infectious mononucleosis. Lancet 1980;i:704.","journal-title":"Lancet"},{"key":"ref_2","first-page":"1077","article-title":"Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome. N Engl 3 Med","volume":"297","author":"Purtillo, D.T.; De Florio, D.; Hutt, L.M.","year":"1977","unstructured":"Purtillo DT, De Florio D, Hutt LM, et al. Variable phenotypic expression of an X-linked recessive lymphoproliferative syndrome. N Engl 3 Med 1977;297:1077-81."},{"key":"ref_3","first-page":"57","article-title":"Lymphocyte markers in non Hodgkin's lymphoma","volume":"36","author":"Payne, S.V.; Smith, J.L.; Jones, D.B.; Wright, D.H.","year":"1976","unstructured":"Payne SV, Smith JL, Jones DB, Wright DH. Lymphocyte markers in non Hodgkin's lymphoma. BrJ7 Cancer 1976;36:57-64."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1002\/eji.1830050411","article-title":"Non specific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes","volume":"5","author":"Mueller, J.; Brun del Re, G.; Buerki, H.; Keller, H.V.; Hess, M.W.; Coutier, H.","year":"1975","unstructured":"Mueller J, Brun del Re G, Buerki H, Keller HV, Hess MW, Coutier H. Non specific acid esterase activity: a criterion for differentiation of T and B lymphocytes in mouse lymph nodes. Eur J Irnmunol 1975;5:270-4.","journal-title":"Eur J Irnmunol"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1038\/195297a0","article-title":"Acid phosphatase activity in human blood cells","volume":"195","author":"Goldberg, A.F.; Barka, T.","year":"1962","unstructured":"Goldberg AF, Barka T. Acid phosphatase activity in human blood cells. Natuire 1962;195:297.","journal-title":"Natuire"},{"key":"ref_6","first-page":"223","article-title":"Cytotoxicity of human T cell population. Scandj7 Immunnol","volume":"11","author":"Bevan, A.; Burns, G.F.; Gray, L.; Cawley, J.C.","year":"1980","unstructured":"Bevan A, Burns GF, Gray L, Cawley JC. Cytotoxicity of human T cell population. Scandj7 Immunnol 1980;11:223."},{"key":"ref_7","first-page":"1157","article-title":"Inhibition of humoral and cell mediated responses in man by distinct suppressor cell systems","volume":"63","author":"Lobo, P.I.; Spencer, C.I.","year":"1979","unstructured":"Lobo PI, Spencer CI. Inhibition of humoral and cell mediated responses in man by distinct suppressor cell systems. _7 Cln Invest 1979;63:1157."},{"key":"ref_8","first-page":"95","article-title":"Non parametric statistics for the behavioral sciences","author":"Seigel, S.","year":"1956","unstructured":"Seigel S. Non parametric statistics for the behavioral sciences. New York: McGraw-Hill, 1956:95-158."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1084\/jem.146.1.184","article-title":"Functional analysis of two human lymphocyte populations: help and suppression of B cell responses by T cells bearing receptors for IgM or IgG","volume":"146","year":"1977","unstructured":"Moretta L, Webb S, Grossi CE, Lydyard PM, Cooper MD. Functional analysis of two human lymphocyte populations: help and suppression of B cell responses by T cells bearing receptors for IgM or IgG. J Exp Med 1977;146:184-200.","journal-title":"J Exp Med"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1126\/science.314668","article-title":"Monoclonal antibodies defining distinctive human T cell surface antigens","volume":"206","author":"Kung, P.C.; Goldstein, G.; Reinherz, E.L.; Schossman, S.F.","year":"1979","unstructured":"' Kung PC, Goldstein G, Reinherz EL, Schossman SF. Monoclonal antibodies defining distinctive human T cell surface antigens. Science 1979;206:347-9.","journal-title":"Science"},{"key":"ref_11","first-page":"40","article-title":"Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses","volume":"117","author":"Ishizaka, K.; Adachi, T.","year":"1976","unstructured":"Ishizaka K, Adachi T. Generation of specific helper cells and suppressor cells in vitro for the IgE and IgG antibody responses. IInmunol 1976; 117:40-7.","journal-title":"IInmunol"},{"key":"ref_12","first-page":"251","article-title":"Lymphocyte sub populations in man: suppression of PWM induced B cell proliferation by infectious mononucleosis T cells","volume":"10","author":"Johnsen, H.E.; Madsen, M.; Kristensen, T.","year":"1979","unstructured":"Johnsen HE, Madsen M, Kristensen T. Lymphocyte sub populations in man: suppression of PWM induced B cell proliferation by infectious mononucleosis T cells. Scandj7 Immunol 1979;10:251-5."},{"key":"ref_13","first-page":"2095","volume":"123","author":"Immunol","year":"1979","unstructured":"_7 Immunol 1979;123:2095-101."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1056\/NEJM197512042932301","article-title":"Cell-mediated immunity to Epstein Barr virus transformed lymphoblastoid cells in acute infectious mononucleosis","volume":"293","author":"Royston, I.; Sullivan, J.L.; Perriman, P.O.; Perlin, E.","year":"1975","unstructured":"Royston I, Sullivan JL, Perriman PO, Perlin E. Cell-mediated immunity to Epstein Barr virus transformed lymphoblastoid cells in acute infectious mononucleosis. N Engl 7 Med 1975;293:1159-63.","journal-title":"N Engl 7 Med"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1056\/NEJM197911223012101","article-title":"Activation of suppressor T cells during Epstein Barr virus induced infectious mononucleosis","volume":"301","author":"Tosato, G.; Magrath, I.; Koski, I.; Dooley, N.; Blaese, M.","year":"1979","unstructured":"Tosato G, Magrath I, Koski I, Dooley N, Blaese M. Activation of suppressor T cells during Epstein Barr virus induced infectious mononucleosis. N EnglJ7 Med 1979;301:1133-7.","journal-title":"N EnglJ7 Med"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.4049\/jimmunol.125.3.1269","article-title":"The cellular basis for viral induced immunodeficiency: analysing monoclonal antibodies","volume":"125","author":"Reinherz, E.L.; O'Brien, C.; Rosenthal, P.; Schlossman, S.F.","year":"1980","unstructured":"Reinherz EL, O'Brien C, Rosenthal P, Schlossman SF. The cellular basis for viral induced immunodeficiency: analysing monoclonal antibodies. J Immunol 1980;125:1269-4.","journal-title":"J Immunol"},{"key":"ref_17","first-page":"132","volume":"i:","author":"immunodeficiency, Anonymous Limited","year":"1978","unstructured":"Anonymous. Limited immunodeficiency. Lancet 1978;i:132-3.","journal-title":"Lancet"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/289300a0","article-title":"Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein Barr virus induced B cell lines","volume":"289","author":"Bird, A.G.; McLachlan, S.M.; Britten, S.","year":"1981","unstructured":"Bird AG, McLachlan SM, Britten S. Cyclosporin A promotes spontaneous outgrowth in vitro of Epstein Barr virus induced B cell lines. Nature 1981 j289:300-1.","journal-title":"Nature"},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1016\/S0140-6736(80)91800-0","article-title":"Epstein Barr virus nuclear antigen positive lymphoma after cyclosporin A treatment in a patient with renal allograft","volume":"i:","author":"Crawford, D.H.; Thomas, J.A.; Janossy, G.","year":"1980","unstructured":"Crawford DH, Thomas JA, Janossy G, et al. Epstein Barr virus nuclear antigen positive lymphoma after cyclosporin A treatment in a patient with renal allograft. Lancet 1980;i:1355-6.","journal-title":"Lancet"},{"key":"ref_20","first-page":"1272","article-title":"Evolution of infectious mononucleosis into Epstein Barr virus carrying monoclonal malignant lymphoma","volume":"i:","author":"Abu, W.; Tokada, K.; Kamada, M.","year":"1982","unstructured":"Abu W, Tokada K, Kamada M, et al. Evolution of infectious mononucleosis into Epstein Barr virus carrying monoclonal malignant lymphoma. Lancet 1982;i: 1272-5.","journal-title":"Lancet"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0140-6736(82)90210-0","article-title":"Prolonged atypical illness associated with serological evidence of persistent Epstein Barr virus infection","volume":"i:","author":"Tobi, M.; Morag, A.; Ravid, Z.","year":"1982","unstructured":"Tobi M, Morag A, Ravid Z, et al. Prolonged atypical illness associated with serological evidence of persistent Epstein Barr virus infection. Lancet 1982;i:61-4.","journal-title":"Lancet"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.4049\/jimmunol.129.6.2536","article-title":"Immune deficiency in the X-linked lymphoproliferative syndrome II. Immunoregulatory T cell defects","volume":"129","author":"Lindsten, T.; Selley, J.K.; Ballow, M.","year":"1982","unstructured":"Lindsten T, Selley JK, Ballow M, et al. Immune deficiency in the X-linked lymphoproliferative syndrome II. Immunoregulatory T cell defects. Jf Immunol 1982;129:2536-40.","journal-title":"Jf Immunol"},{"article-title":"Accepted","year":"1983","key":"ref_23","unstructured":"(Accepted 7 April 1983)"},{"key":"ref_24","unstructured":"The reasons for poor compliance are numerous. Hypertension is often asymptomatic and may necessitate lifelong treatment that is costly and sometimes poorly tolerated. Improving compliance requires the combined efforts of both the patient and the doctor.3 In this study we determined the risk factors present at the first visit associated with low compliance with appointments and poor treatment results in hypertensive patients attending thc Saint-Joseph Hospital hypertension clinic between January 1976 and December 1978 and enrolled in the computerised Artemis system.4 The methods adopted in this prospective study were similar to those used for predicting fatal or non-fatal cardiovascular complications in cohort studies.5 6 We considered that early detection of patients at high risk of dropping outl might improve the management of patients with hypertension.","article-title":"The reasons for poor compliance are numerous. Hypertension is often asymptomatic and may necessitate lifelong treatment that is costly and sometimes poorly tolerated. Improving compliance requires the combined efforts of both the patient and the doctor.3 In this study we determined the risk factors present at the first visit associated with low compliance with appointments and poor treatment results in hypertensive patients attending thc Saint-Joseph Hospital hypertension clinic between January 1976 and December 1978 and enrolled in the computerised Artemis system.4 The methods adopted in this prospective study were similar to those used for predicting fatal or non-fatal cardiovascular complications in cohort studies.5 6 We considered that early detection of patients at high risk of dropping outl might improve the management of patients with hypertension"},{"key":"ref_25","article-title":"2920 patients were referred to the hospital's outpatient hypertension clinic. Altogether 1346 records were analvsed and selected by according to two","author":"1, Between","year":"1976","unstructured":"Between 1 January 1976 and 31 December 1978, 2920 patients were referred to the hospital's outpatient hypertension clinic. Altogether 1346 records were analvsed and selected by according to two"}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.287.6385.85","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.287.6385.85","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T21:54:32Z","timestamp":1765317272000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.287.6385.85"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,7,9]]},"references-count":25,"journal-issue":{"issue":"6385","published-online":{"date-parts":[[1983,7,9]]},"published-print":{"date-parts":[[1983,7,9]]}},"alternative-id":["10.1136\/bmj.287.6385.85"],"URL":"https:\/\/doi.org\/10.1136\/bmj.287.6385.85","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,7,9]]}}}