{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:19:57Z","timestamp":1765318797252,"version":"3.46.0"},"reference-count":21,"publisher":"BMJ","issue":"6391","license":[{"start":{"date-parts":[[1983,8,20]],"date-time":"1983-08-20T00:00:00Z","timestamp":430185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.bmj.com\/company\/legal-information\/terms-conditions\/legal-information\/tdm-licencepolicy"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br Med J (Clin Res Ed)"],"published-print":{"date-parts":[[1983,8,20]]},"abstract":"<jats:p>The prevalence of autoimmune diseases, including systemic lupus erythematosus, is increased in failure of certain host defence mechanisms. Systemic lupus erythematosus, however, has not been recorded as a late complication of the Staphylococcus aureus hyperimmunoglobulinaemia E (hyper-IgE) syndrome. Such a case was investigated in a man suffering from a classic example of the syndrome. Antinuclear antibodies were analysed on a molecular basis. The emergence of immunological and clinical features of systemic lupus erythematosus in patients with defective host defence mechanisms against staphylococcal infections is unlikely to be fortuitous and may help elucidate the pathogenesis of systemic lupus erythematosus. The observations will also aid the long term management of patients with S aureus hyper-IgE syndrome.<\/jats:p>","DOI":"10.1136\/bmj.287.6391.524","type":"journal-article","created":{"date-parts":[[2009,4,2]],"date-time":"2009-04-02T11:00:59Z","timestamp":1238670059000},"page":"524-526","source":"Crossref","is-referenced-by-count":24,"title":["Systemic lupus erythematosus in Staphylococcus aureus hyperimmunoglobulinaemia E syndrome."],"prefix":"10.1136","volume":"287","author":[{"given":"K","family":"Schopfer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Feldges","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Baerlocher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R F","family":"Parisot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A","family":"Wilhelm","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L","family":"Matter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[1983,8,20]]},"reference":[{"key":"ref_1","first-page":"1013","article-title":"Job's syndrome: recurrent \"cold,\" staphylococcal abscesses","volume":"i:","author":"Davis, S.D.; Schaller, J.; Wedgwood, R.J.","year":"1966","unstructured":"Davis SD, Schaller J, Wedgwood RJ. Job's syndrome: recurrent \"cold,\" staphylococcal abscesses. Lancet 1966;i:1013-5.","journal-title":"Lancet"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1542\/peds.49.1.59","article-title":"Extreme hyperimmunoglobulinemia E and undue susceptibility to infection","volume":"49","author":"Buckley, R.H.; Wray, B.B.; Belmaker, E.Z.","year":"1972","unstructured":"Buckley RH, Wray BB, Belmaker EZ. Extreme hyperimmunoglobulinemia E and undue susceptibility to infection. Pediatrics 1972;49:59-70.","journal-title":"Pediatrics"},{"key":"ref_3","first-page":"147","article-title":"The hyperimmunoglobulinaemia E syndrome","volume-title":"Clinical immunology update 1981","author":"Buckley, R.H.; Sampson, H.A.","year":"1981","unstructured":"Buckley RH, Sampson HA. The hyperimmunoglobulinaemia E syndrome. In: Franklin EC, ed. Clinical immunology update 1981. Edinburgh: Churchill Livingstone, 1981:147-67."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0140-6736(74)92493-3","article-title":"Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections","volume":"i:","author":"Hill, H.R.; Quie, P.G.","year":"1974","unstructured":"Hill HR, Quie PG. Raised serum-IgE levels and defective neutrophil chemotaxis in three children with eczema and recurrent bacterial infections. Lancet 1974;i:183-97.","journal-title":"Lancet"},{"issue":"9","key":"ref_5","first-page":"1155","article-title":"Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent \"cold\" staphylococcal abscesses","volume":"617","author":"Hill, H.R.; Ochs, H.D.; Quie, P.G.","year":"1974","unstructured":"Hill HR, Ochs HD, Quie PG, et al. Defect in neutrophil granulocyte chemotaxis in Job's syndrome of recurrent \"cold\" staphylococcal abscesses. Lancet 1974;ii:617-9. 6 Donabedian H, Gallin JI. Mononuclear cells from patients with the hyperimmunoglobulinemia E-recurrent infection syndrome produce an inhibitor of leukocyte chemotaxis. J Clin Invest 1982;69:1155-63.","journal-title":"Lancet; Mononuclear cells from patients with the hyperimmunoglobulinemia E-recurrent infection syndrome produce an inhibitor of leukocyte chemotaxis"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1056\/NEJM197904123001506","article-title":"Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections","volume":"300","author":"Schopfer, K.; Baerlocher, K.; Price, P.; Krech, U.; Quie, P.G.; Douglas, S.D.","year":"1979","unstructured":"Schopfer K, Baerlocher K, Price P, Krech U, Quie PG, Douglas SD. Staphylococcal IgE antibodies, hyperimmunoglobulinemia E and Staphylococcus aureus infections. N EnglJ Med 1979;300:835-8.","journal-title":"N EnglJ Med"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"2437","DOI":"10.4049\/jimmunol.125.6.2437","article-title":"IgE antibodies to Staphylococcus aureus and Candida albicans in patients with the syndrome of hyperimmunoglobulinema E and recurrent infections","volume":"125","author":"Berger, M.C.; Kirkpatrick, C.H.; Goldsmith, P.K.; Gallin, J.I.","year":"1980","unstructured":"Berger MC, Kirkpatrick CH, Goldsmith PK, Gallin JI. IgE antibodies to Staphylococcus aureus and Candida albicans in patients with the syndrome of hyperimmunoglobulinema E and recurrent infections. J Immunol 1980;125:2437-43.","journal-title":"J Immunol"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1111\/j.1600-065X.1978.tb01469.x","article-title":"Abnormalities in the regulation of human IgE synthesis","volume":"41","author":"Buckley, R.H.; Becker, W.G.","year":"1978","unstructured":"Buckley RH, Becker WG. Abnormalities in the regulation of human IgE synthesis. Immunol Rev 1978;41:288-314. 1' Geha RS, Reinherz E, Leung D, McKee KT, Schlossman S, Rosen FS.","journal-title":"Immunol Rev; Rosen FS"},{"key":"ref_9","first-page":"\"783","article-title":"Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome","volume":"68","author":"Cancer","year":"1981","unstructured":"Deficiency of suppressor T cells in the hyperimmunoglobulin E syndrome. J Clin Invest 1981;68:783-9 1. \"Bale JF Jr, Wilson JF, Hill HR. Fatal histiocytic lymphoma of the brain associated with hyperimmunoglobulinemia E and recurrent infections. Cancer 1977;39:2386-90.","journal-title":"J Clin Invest; 1. \"Bale JF Jr, Wilson JF, Hill HR. Fatal histiocytic lymphoma of the brain associated with hyperimmunoglobulinemia E and recurrent infections"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"\"323","DOI":"10.1007\/978-94-011-6197-8_23","article-title":"Antigen-induced neutrophil dysfunction in a patient with chronic eczema, recurrent \"cold\" staphylococcal infections and hyperimmunoglobulinaemia","volume":"116","author":"Schopfer, K.; Baerlocher, K.","year":"1979","unstructured":"Schopfer K, Baerlocher K. Antigen-induced neutrophil dysfunction in a patient with chronic eczema, recurrent \"cold\" staphylococcal infections and hyperimmunoglobulinaemia E. In: Guettler F, ed. Inborn errors of immunity and phagocytosis. Lancaster: MTP Press Limited, 1979: 323-30.: Zubler RH, Lange G, Lambert PH, Miescher PA. Detection of immune complexes in unheated sera by a modified '251-Clq binding test. Effect of heating on the binding of Clq by immune complexes and application of the test to systemic lupus erythematosus. J Immunol 1976;116:232-5.","journal-title":"J Immunol; errors of immunity and phagocytosis"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1002\/art.1780251102","article-title":"Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies: a diagnostic evaluation","volume":"25","author":"Matter, L.; Schopfer, K.; Wilhelm, J.A.; Nyffenegger, T.; Parisot, R.F.; de Robertis, E.M.","year":"1982","unstructured":"Matter L, Schopfer K, Wilhelm JA, Nyffenegger T, Parisot RF, de Robertis EM. Molecular characterization of ribonucleoprotein antigens bound by antinuclear antibodies: a diagnostic evaluation. Arthritis Rheum 1982;25:1278-83.","journal-title":"Arthritis Rheum"},{"key":"ref_12","first-page":"3","article-title":"Systemic lupus erythematosus. In: Connective tissute diseases","author":"Hughes, G.R.V.","year":"1979","unstructured":"Hughes GRV. Systemic lupus erythematosus. In: Connective tissute diseases. 2nd ed. Oxford: Blackwell Scientific Publications, 1979:3-72.","edition":"2nd ed"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1172\/JCI106502","article-title":"Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy","volume":"50","author":"Sharp, C.G.; Irvin, W.S.; LaRoque, R.L.","year":"1971","unstructured":"Sharp CG, Irvin WS, LaRoque RL, et al. Association of autoantibodies to different nuclear antigens with clinical patterns of rheumatic disease and responsiveness to therapy. J ClGn Invest 1971;50:350-9.","journal-title":"J ClGn Invest"},{"key":"ref_14","first-page":"1893","article-title":"Canine systemic lupus erythematosus","volume":"52","author":"Lewis, R.M.; Schwartz, J.H.; Harris, G.S.; Hirsch, M.S.; Black, P.A.; Schwartz, R.M.","year":"1973","unstructured":"Lewis RM, Schwartz JH, Harris GS, Hirsch MS, Black PA, Schwartz RM. Canine systemic lupus erythematosus. J ClGn Invest 1973;52: 1893-1907.","journal-title":"J ClGn Invest"},{"issue":"21","key":"ref_15","article-title":"Association of SLE and SLE-like syndromes with hereditary and acquired complement deficiency states","volume":"1978","author":"Agnello, V.","unstructured":"Agnello V. Association of SLE and SLE-like syndromes with hereditary and acquired complement deficiency states. Arthritis Rheum 1978;21, suppl 5:146.","journal-title":"Arthritis Rheum"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/0090-1229(79)90098-9","article-title":"The prevalence of autoantibodies in T cell, B cell and phagocytic immunodeficiency disorders","volume":"14","author":"Ammann, A.J.; Wara, D.W.; Pillarisetty, R.J.; Talal, N.","year":"1979","unstructured":"Ammann AJ, Wara DW, Pillarisetty RJ, Talal N. The prevalence of autoantibodies in T cell, B cell and phagocytic immunodeficiency disorders. Clin Immunol Immunopathol 1979;14:456-66.","journal-title":"Clin Immunol Immunopathol"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0065-2776(08)60836-6","article-title":"Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine","volume":"33","author":"Tan, E.M.","year":"1982","unstructured":"Tan EM. Autoantibodies to nuclear antigens (ANA): their immunobiology and medicine. Adv Immunol 1982;33:167-240.","journal-title":"Adv Immunol"},{"article-title":"Accepted 17","year":"1983","key":"ref_18","unstructured":"(Accepted 17 May 1983)"},{"issue":"9\/1000","key":"ref_19","first-page":"smears)","article-title":"A retrospective study was conducted to examine the pattern of a disturbing increase in abnormal cervical smears in one health district. Past records over fifteen years (1965-79) were analysed to produce pick up rates according to age, screening state, severity of lesion, and area of residence. Main findings included an increased pick up rate","volume-title":"unscreened (5 8 to; 3-6\/1000 smears) women. The order of increase was proportionately much higher in women under 40 years. The only significant epidemiological variable in the catchment area was a substantial population increase, overweighted by the younger age groups","volume":"12","unstructured":"A retrospective study was conducted to examine the pattern of a disturbing increase in abnormal cervical smears in one health district. Past records over fifteen years (1965-79) were analysed to produce pick up rates according to age, screening state, severity of lesion, and area of residence. Main findings included an increased pick up rate in unscreened (5 8 to 12 9\/1000 smears) and screened (0 9 to 3-6\/1000 smears) women. The order of increase was proportionately much higher in women under 40 years. The only significant epidemiological variable in the catchment area was a substantial population increase, overweighted by the younger age groups."},{"key":"ref_20","unstructured":"The returns made to the DHSS may be misleading for various reasons. The number of positive smears is not broken down by histological diagnosis and may include smears from patients with genital tract carcinomas other than cervical. They also include cytological false positive smears and cases of recurrent or residual neoplastic lesions of the cervix. The total number of smears examined gives no indication of the age groups or screening state of the women concerned. We therefore decided to analyse retrospectively the work done by the laboratory and to look for factors that might have contributed to an approximate doubling of the pick up rate of abnormal smears in the DHSS returns between 1975 and 1979 (8-9\/1000 smears examined) compared with the previous 10 years (4-7\/1000 smears examined). These included alterations in reporting by the laboratory, differences in screening practices, and changes in the population served.","article-title":"The returns made to the DHSS may be misleading for various reasons. The number of positive smears is not broken down by histological diagnosis and may include smears from patients with genital tract carcinomas other than cervical. They also include cytological false positive smears and cases of recurrent or residual neoplastic lesions of the cervix. The total number of smears examined gives no indication of the age groups or screening state of the women concerned. We therefore decided to analyse retrospectively the work done by the laboratory and to look for factors that might have contributed to an approximate doubling of the pick up rate of abnormal smears in the DHSS returns between 1975 and 1979 (8-9\/1000 smears examined) compared with the previous 10 years (4-7\/1000 smears examined). These included alterations in reporting by the laboratory, differences in screening practices, and changes in the population served"},{"key":"ref_21","first-page":"30","article-title":"A 10, sample was taken of all smears examined during the 15 years 1965-79. For each smear a record was made of the age of the woman, the year the smear was taken, and whether or not the women had had a previous smear examined at the laboratory. These results were used to estimate the total number of smears taken from previously screened and unscreened women in each of the four age groups","volume-title":"and 50 during the three five year periods 1965-9, 1970-4, and 1975-9. Women who had had a previous smear examined at the hospital were classified as \"screened.\" Information on smears taken elsewhere was unreliable, and for records where the only indication of a previous smear related to some other laboratory the smears were classified as screened or unscreened in the same proportions as for the other women in the appropriate subgroup","volume":"30","unstructured":"A 10, sample was taken of all smears examined during the 15 years 1965-79. For each smear a record was made of the age of the woman, the year the smear was taken, and whether or not the women had had a previous smear examined at the laboratory. These results were used to estimate the total number of smears taken from previously screened and unscreened women in each of the four age groups < 30, 30-39, 40-49, and 50 during the three five year periods 1965-9, 1970-4, and 1975-9. Women who had had a previous smear examined at the hospital were classified as \"screened.\" Information on smears taken elsewhere was unreliable, and for records where the only indication of a previous smear related to some other laboratory the smears were classified as screened or unscreened in the same proportions as for the other women in the appropriate subgroup."}],"container-title":["BMJ"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/data.bmj.org\/tdm\/10.1136\/bmj.287.6391.524","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmj.287.6391.524","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T22:15:28Z","timestamp":1765318528000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.bmj.com\/lookup\/doi\/10.1136\/bmj.287.6391.524"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,8,20]]},"references-count":21,"journal-issue":{"issue":"6391","published-online":{"date-parts":[[1983,8,20]]},"published-print":{"date-parts":[[1983,8,20]]}},"alternative-id":["10.1136\/bmj.287.6391.524"],"URL":"https:\/\/doi.org\/10.1136\/bmj.287.6391.524","relation":{},"ISSN":["0007-1447","1468-5833"],"issn-type":[{"type":"print","value":"0007-1447"},{"type":"electronic","value":"1468-5833"}],"subject":[],"published":{"date-parts":[[1983,8,20]]}}}